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Encyclopedia > Zonula Occludens

Zonula Occludens or tight junctions are the closely associated areas of the two cells whose membranes join together forming a virtual impermeable barrier to fluid.


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Cell Isolation Theory (2479 words)
On the lateral surfaces of adjacent epithelial cells there are four distinct types of intercellular bonds: the zonula occludens, zonula adherens, macula adherens and nexus.
In the zonula occludens, or "tight junction", there are multiple sites of actual fusion of the adjacent unit membranes interspersed by short regions of unit membrane separation of approximately 100-150 Å.
In a zonula adherens, or "intermediate junction", a fine network of cytoplasmic filaments radiates from the cell membrane into the cytoplasm.
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