FACTOID # 23: Wisconsin has more metal fabricators per capita than any other state.
 Home   Encyclopedia   Statistics   States A-Z   Flags   Maps   FAQ   About 


FACTS & STATISTICS    Advanced view

Search encyclopedia, statistics and forums:



(* = Graphable)



Encyclopedia > Ziconotide

Ziconotide is a non-opioid, non local anesthetic used for the amelioration of chronic pain. It is the synthetic form of the cone snail peptide w-conotoxin M-VII-A, an N-type calcium channel blocker. Opium is a narcotic drug which is obtained from the unripe seed pods of the opium poppy . ... A wide variety of drugs are used in modern anaesthetic practice. ... Chronic pain is medically defined as pain that has lasted 6 months or longer. ... Synthesis (from the Greek words syn = plus and thesis = position) is commonly understood to be an integration of two or more pre-existing elements which results in a new creation. ... The cone snails (Conus spp. ... Peptides are the family of molecules formed from the linking, in a defined order, of various amino acids. ... Conotoxins are toxins from cone snails. ... Calcium channel blockers are a class of drugs with effects on the muscle of the heart and the muscles of the rest of the body. ...

The brand name for the drug is Prialt®. This article is about brands in marketing. ...

In December 2004 the Food and Drug Administration approved ziconotide when delivered as an infusion into the cerebrospinal fluid using a intrathecal pump system. The United States Food and Drug Administration is the government agency responsible for regulating food, dietary supplements, drugs, cosmetics, medical devices, biologics and blood products in the United States. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Cerebrospinal fluid, CSF in short, is the clear fluid that occupies the subarachnoid space (the space between the skull and cortex of the brain). ... Intrathecal: Delivered into the spinal canal (intrathecal space surrounding the spinal cord), as in a spinal anaesthesia. ... An infusion pump or perfusor infuses fluids, medication or nutrients into a patients circulatory system. ...


The drug was patented by Neurex Corp., a U.S. company purchased in 1998 by Élan Corporation, plc of Ireland. U.S. patents assigned to Elan include 5,859,186, 5,795,864, 5,770,690, 5,587,454, and 5,559,095. 1998 is a common year starting on Thursday of the Gregorian calendar, and was designated the International Year of the Ocean. ... Élan Corporation plc (NYSE: ELN), (LSE: ELA) is a major drugs firm based in Athlone, County Westmeath, Ireland. ... A true colour image of Ireland, captured by a NASA satellite on January 4, 2003. ...

External links

  • FDA approves new drug for severe pain (http://www.cnn.com/2004/HEALTH/12/29/pain.medicine.ap/), a December 2004 Associated Press article
  • Press release announcing FDA approval (http://www.elan.com/News/full.asp?ID=657731) from Elan
  • Ziconotide Effectiveness and Safety Trial in Patients with Chronic Severe Pain (http://www.clinicaltrials.gov/ct/gui/show/NCT00076544)



Share your thoughts, questions and commentary here
Your name
Your comments

Want to know more?
Search encyclopedia, statistics and forums:


Press Releases |  Feeds | Contact
The Wikipedia article included on this page is licensed under the GFDL.
Images may be subject to relevant owners' copyright.
All other elements are (c) copyright NationMaster.com 2003-5. All Rights Reserved.
Usage implies agreement with terms, 1022, m