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Encyclopedia > XK (protein)
[[Image:|250px|XK (protein) chemical structure]]
XK (protein)
Identifiers
Symbol(s) XK XKR1, Kx, X1k
Entrez 7504
OMIM 314850
RefSeq NM_021083
UniProt P51811
PDB BAE48708
Other data
EC number [1]
Locus Chr. X p21.2-p21.1

XK (also known as Kell blood group precursor) is a protein found on human red blood cells and other tissues which is responsible for the Kx antigen which helps determine a person's blood type. The Kx antigen plays a role in matching blood for blood transfusions. Absence of XK protein leads to McLeod syndrome, a multi-system disorder characterized by hemolytic anemia, myopathy, acanthocytosis, and chorea. [1] Hugo is a masculine name. ... The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... The Protein Data Bank (PDB) is a repository for 3-D structural data of proteins and nucleic acids. ... The Enzyme Commission number (EC number) is a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. ... In biology and evolutionary computation, a locus is the position of a gene (or other significant sequence) on a chromosome. ... The X chromosome is one of the two sex chromosomes in mammals (the other is the Y chromosome). ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ... Human red blood cells Red blood cells are the most common type of blood cell and are the vertebrate bodys principal means of delivering oxygen to body tissues via the blood. ... An antigen is a substance that stimulates an immune response, especially the production of antibodies. ... A total of 29 human blood group systems are recognized by the International Society of Blood Transfusion (ISBT). ... Blood transfusion is the taking of blood or blood-based products from one individual and inserting them into the circulatory system of another. ... McLeod syndrome (or McLeod phenomenon) is a genetic disorder caused by presence of the McLeod phenotype, a recessive anomaly on the X chromosome which alters production of XK protein (a precursor of Kell antigens on the surface of red blood cells). ... Hemolytic anemia is anemia due to hemolysis, the abnormal breakdown of red blood cells either in the blood vessels (intravascular hemolysis) or elsewhere in the body (extravascular). ... In medicine, a myopathy is a neuromuscular disease in which the muscle fibers dysfunction for any one of many reasons, resulting in muscular weakness. ... Acanthocytes are red blood cells that show many spicules (small needlelike structures) when viewed on a wet film. ... Chorea may refer to: Chorea, an ancient Greek round dance accompanied by singing. ...


XK is located on the X chromosome and absence of the XK protein is an X-linked disease.[2] XK is a membrane transport protein of unknown action.[3] The X chromosome is one of the two sex chromosomes in mammals (the other is the Y chromosome). ... Sex linkage is the phenotypic expression of an allele that is dependent on the sex of the individual and is directly tied to the sex chromosomes. ... Drawing of a cell membrane A component of every biological cell, the selectively permeable cell membrane (or plasma membrane or plasmalemma) is a thin and structured bilayer of phospholipid and protein molecules that envelopes the cell. ...


References

OMIM 314850- OMIM entry on XK protein

  1. ^ Malandrini A, Fabrizi GM, Truschi F, Di Pietro G, Moschini F, Bartalucci P, Berti G, Salvadori C, Bucalossi A, Guazzi G. Atypical McLeod syndrome manifested as X-linked chorea-acanthocytosis, neuromyopathy and dilated cardiomyopathy: report of a family. J Neurol Sci. 1994 Jun;124(1):89-94. PMID 7931427
  2. ^ Ho MF, Monaco AP, Blonden LA, van Ommen GJ, Affara NA, Ferguson-Smith MA, Lehrach H. Fine mapping of the McLeod locus (XK) to a 150-380-kb region in Xp21. Am J Hum Genet. 1992 Feb;50(2):317-30. PMID 1734714
  3. ^ Jung HH, Russo D, Redman C, Brandner S. Kell and XK immunohistochemistry in McLeod myopathy. Muscle Nerve. 2001 Oct;24(10):1346-51. PMID 11562915
Transfusion medicine - edit
Blood transfusion | Cross-matching | Coombs test | Intraoperative blood salvage | Transfusion reactions | International Society of Blood Transfusion | ISBT 128 | Platelet transfusion |
Human blood group systems - Blood type
ABO | Rhesus | Duffy | Hh | Kell | Kidd | Kx | Colton | Yt
Blood products
Blood donation | Blood | Plasma | Platelets | Cryoprecipitate | Plasmapheresis | Red blood cells 

 
 

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