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Encyclopedia > Vulvar intraepithelial neoplasia

The term vulvar intraepithelial neoplasia (VIN) denotes a squamous intraepithelial lesion of the vulva that shows dysplasia with varying degrees of atypia. The epithelial basement membrane is intact and the lesion is thus not invasive but has invasive potential. The external genital organs of the female are collectively known as the vulva (plural vulvae, vulvas). ... Dysplasia (latin for bad form) is an abnormality in the appearance of cells indicative of an early step towards transformation into a neoplasia. ... Atypia is a clinical term for abnormality in a cell. ... ...


ISSVD Classification

The terminology of VIN evolved over several decades. In 1989 the Committee on Terminology, International Society for the Study of Vulvar Disease (ISSVD) replaced older terminology such as vulvar dystrophy, Bowen's disease, and Krausosis vulvae by a new classification system for Epithelial Vulvar Disease: 1989 (MCMLXXXIX) was a common year starting on Sunday of the Gregorian calendar. ... Dystrophy is any condition of abnormal development, usually due to malnutrition, especially denoting the degeneration of muscles (muscular dystrophy). ... In medicine (dermatology), Bowens disease (BD) is a sunlight-induced skin disease, considered either as an early stage or intraepidermal form of squamous cell carcinoma. ...

  • Nonneoplastic epithelial disorders of vulva and mucosa:
  • Mixed neoplastic and nonneoplastic disorders
  • Intraepithelial neoplasia
  • Invasive disease (vulvar carcinoma)

Lichen sclerosus (LS) (also known as lichen sclerosus et atrophicus (LSA), white-spot disease) is an uncommon disease of unknown cause that results in white patches on the skin, which may cause scarring on and around genital skin. ... Carcinoma in situ is present when a tumor has been detected that has the characteristics of malignancy but has not invaded other tissues. ... This article or section does not cite its references or sources. ... Vulvar cancer, a malignant invasive growth in the vulva, accounts for about 4 % of all gynecological cancers and typically affects women in later life. ...


The patient may have no symptoms, or local symptomatology including itching, burning, and pain. The diagnosis is always based on a careful inspection and a targeted biopsy. A biopsy (in Greek: bios = life and opsy = look/appearance) is a medical test involving the removal of cells or tissues for examination. ...


The treatment of VIN is local to wide excision, in case of very extensive involvement or recurrency even a simple vulvectomy. Laser therapy has also been useful for VIN. Vulvectomy refers to a gynecological procedure in which the vulva is partly or completely removed. ...


  • Committee on Terminology, ISSVD: New nomenclature for vulvar disease. Int J Gynecol Pathol 1989;8:83.

External links

  • VIN at DermNet.NZ
  • VIN at Cancerbackup.org



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