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Encyclopedia > Vinpocetine
Vinpocetine chemical structure
Vinpocetine
Systematic (IUPAC) name
 ?
Identifiers
CAS number 42971-09-5
ATC code N06BX18
PubChem 5673
Chemical data
Formula C22H26N2O2 
Mol. weight 350.454 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? Image File history File links Vinpocetine. ... IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... General Name, Symbol, Number carbon, C, 6 Chemical series nonmetals Group, Period, Block 14, 2, p Appearance black (graphite) colorless (diamond) Atomic mass 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number nitrogen, N, 7 Chemical series nonmetals Group, Period, Block 15, 2, p Appearance colorless Atomic mass 14. ... General Name, Symbol, Number oxygen, O, 8 Chemical series Nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Atomic mass 15. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Overview of the citric acid cycle The citric acid cycle, one of the central metabolic pathways in aerobic organisms. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Vinpocetine (brand names: Cavinton, Intelectol; chemical name: ethyl apovincaminate) is a semisynthetic derivative of vincamine, which is extracted from the periwinkle plant. It increases cerebral blood flow and is said to improve memory. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Vincamine is a peripheral vasodilator. ... Periwinkle is. ...


It is an inhibitor of Phosphodiesterases I and IV, with an IC50 of approximately 10^-5 M. cGMP cAMP Phosphodiesterase (PDE) is a group of enzymes that degrade the second messenger molecules: cyclic nucleotides cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. ... The term IC50 represents the concentration of an inhibitor that is required for 50% inhibition of things like an enzyme, a cell receptor or a microorganism. ...



The substance is widely sold as a supplement on the Internet and has been sold via health food stores, however there appears to be some controversy over the possibility of adverse reaction, and low initial dose is recommended by one retailer, whereas others claim it is safe and wonderful. There is one isolated claim of severe reaction, a life-threatening condition called agranulocytosis. The patient was in terrible shape and had many other medications.


External links

  • Erowid Vinpocetine Vault
  • Vinpocetine article from PDRhealth


Stimulants - edit

Adrafinil, Armodafinil, Caffeine, Modafinil, Nicotine Stimulants are drugs that increase alertness and wakefulness. ... Adrafinil chemical structure Adrafinil is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention in elderly patients. ... Armodafinil (Nuvigil®) is a drug produced by the pharmaceutical company Cephalon, currently in the process of receiving FDA approval. ... Caffeine is a xanthine alkaloid compound that acts as a stimulant in humans. ... Modafinil (commercial trade names Provigil (US, UK, Italy), Vigil (Germany), Modalert (India), Modiodal (France, Mexico, Turkey), Modavigil (Australia), Alertec (Canada), and possibly Vigicer) is a eugeroic drug generally prescribed to treat narcolepsy, made by the pharmaceutical company Cephalon Inc. ... Nicotine is an alkaloid found in the nightshade family of plants (Solanaceae), predominantly in tobacco, and in lower quantities in tomato, potato, eggplant (aubergine), and green pepper. ...


Sympathomimetic amines (R01, A08, and others) edit

Aminorex, Amphetamine, Benzylpiperazine, Cathinone, CFT, Chlorphentermine, Clobenzorex, Cocaine, Cyclopentamine, Diethylpropion, Ephedrine, Fenfluramine, Mazindol, 4-Methyl-aminorex, Methylone, Methylphenidate, Pemoline, Phendimetrazine, Phenmetrazine, Phentermine, Phenylephrine, Propylhexedrine, Pseudoephedrine, Sibutramine, Synephrine Sympathomimetic drugs are substances that mimic the effects of the hormone adrenaline. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A division of the Anatomical Therapeutic Chemical Classification System A Alimentary tract and metabolism A08A Antiobesity preparations, excluding diet products A08AA Centrally acting antiobesity products A08AA01 Phentermine A08AA02 Fenfluramine A08AA03 Amfepramone A08AA04 Dexfenfluramine A08AA05 Mazindol A08AA06 Etilamfetamine A08AA07 Cathine A08AA08 Clobenzorex A08AA09 Mefenorex A08AA10 Sibutramine A08AA56 Ephedrine, combinations A08AB Peripherally... Wikipedia does not yet have an article with this exact name. ... Amphetamine (alpha-methyl-phenethylamine), also known as speed or crank, is a stimulant, and club drug, used to diminish the appetite, control weight, and treat disorders including narcolepsy and attention-deficit hyperactivity disorder. ... Benzylpiperazine (BZP) is a recreational drug with euphoric, stimulant effects. ... Cathinone (β-ketoamphetamine) is a monoamine alkaloid found in the shrub Catha edulis (Khat). ... (-)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane naphthalenedisulfonate (CFT) is a dopamine reuptake inhibitor structurally similar to cocaine. ... Clobenzorex (also known under the brand names Asenlix, Finedal, or Rexigen; or the US slang greenies) is a stimulant drug used as an anorectic (that is, a medication that suppresses appetite). ... For other uses, see Cocaine (disambiguation). ... Cyclopentamine is a stimulant drug structurally related to methamphetamine, wherein the aromatic phenyl ring is replaced with a cyclopentane ring. ... Diethylpropion (Tenuate®) is a sympathomimetic stimulant drug marketed as an appetite suppressant. ... Ephedrine (EPH) is a sympathomimetic amine similar in structure to the synthetic derivatives amphetamine and methamphetamine. ... Fenfluramine is a drug that was part of the Fen-Phen anti-obesity (the other drug being phentermine). ... 4-Methylaminorex is a stimulant drug of the 2-Amino-5-Aryloxazoline class. ... Methylone is a designer drug that is an analog of MDMA (Ecstasy). ... Methylphenidate (MPH) is an amphetamine-like prescription stimulant commonly used to treat Attention Deficit Hyperactivity Disorder (ADHD) in children and adults. ... Pemoline is a medication for Attention-deficit hyperactivity disorder (ADHD). ... Phendimetrazine (Bontril®) is a weight loss medication. ... Phenmetrazine is an amphetamine-like drug. ... Phentermine is a drug primarily used as an appetite suppressant. ... Phenylephrine or neosynephrine is an α-agonist used primarily as a decongestant, as an agent to dilate the pupil, and rarely to increase blood pressure. ... Basics: Propylhexedrine is an over-the-counter nasal decongestant found in Benzedrex nasal inhalers. ... Pseudoephedrine (commonly abbreviated as PSE) is a sympathomimetic amine commonly used as a decongestant. ... Sibutramine (Meridia® in the USA, Reductil® in Europe), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. ... Synephrine Synephrine is a dietary supplement aimed at encouraging fat loss. ...

See also amphetamines


Amphetamine (alpha-methyl-phenethylamine), also known as speed or crank, is a stimulant, and club drug, used to diminish the appetite, control weight, and treat disorders including narcolepsy and attention-deficit hyperactivity disorder. ...

Selective Phosphodiesterase inhibitors (C01CE, G04BE)edit
PDE1:

Vinpocetine A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ...

PDE2:

EHNA EHNA (erythro-9-(2-hydroxy-3-nonyl)adenine) is a phosphodiesterase inhibitor that selectively inhibits phosphodiesterase type-2 (PDE2). ...

PDE3:

Amrinone, Bucladesine, Enoximone, Milrinone Amrinone (INN) or inamrinone, trade name Inocor®, is a pyridine phosphodiesterase inhibitor. ... Bucladesine is a phosphodiesterase inhibitor. ... Enoximone (INN, trade name Perfan®) is an imidazole phosphodiesterase inhibitor. ... Milrinone is a phosphodiesterase III inhibitor. ...

PDE4:

Rolipram Rolipram is a phosphodiesterase inhibitor. ...

PDE5:

Sildenafil, Tadalafil, Vardenafil Sildenafil citrate, sold under the names Viagra, Revatio and generically under various other names, is a drug used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH), developed by the pharmaceutical company Pfizer. ... Tadalafil is a drug used to treat male erectile dysfunction (impotence). ... Vardenafil (INN) is a PDE5 inhibitor used in the treatment of erectile dysfunction. ...


  Results from FactBites:
 
Vinpocetine (1213 words)
Vinpocetine is also known as ethyl apovincaminate; ethyl apovincaminoate; eburnamenine-14-carboxylic acid ethyl ester; 3 alpha, 16 alpha-apovincaminic acid ethyl ester; ethyl apovincamin-22-oate; and cavinton, which is sometimes used generically for a branded product with that name.
In addition, vinpocetine has been shown to inhibit a cyclic GMP phosphodiesterase, and it is speculated that this inhibition enhances cyclic GMP levels in the vascular smooth muscle, leading to reduced resistance of cerebral vessels and increase of cerebral flow.
Vinpocetine is absorbed from the small intestine, from whence it is transported to the liver via the portal circulation.
Vinpocetine : by Ray Sahelian, M.D., Vinpocetine 10 mg 90 caps (2809 words)
Vinpocetine appears to be beneficial in cognitive disorders that are due to poor blood flow to the brain.
Asymptomatic ischemic cerebrovascular disorders and neuroprotection with vinpocetine.
Vinpocetine inhibited the ascorbate/Fe2+ stimulated consumption of oxygen and TBARS accumulation, an indicator of lipid peroxidation, in a concentration-dependent manner.
  More results at FactBites »

 
 

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