FACTOID # 6: Michigan is ranked 22nd in land area, but since 41.27% of the state is composed of water, it jumps to 11th place in total area.
 
 Home   Encyclopedia   Statistics   States A-Z   Flags   Maps   FAQ   About 
   
 
WHAT'S NEW
 

SEARCH ALL

FACTS & STATISTICS    Advanced view

Search encyclopedia, statistics and forums:

 

 

(* = Graphable)

 

 


Encyclopedia > Valganciclovir
Jump to: navigation, search

Valganciclovir hydrochloride (Valcyte®) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. Antiviral drugs are a class of medication used specifically for treating viral infections. ... Jump to: navigation, search A medication is a licenced drug taken to cure or reduce symptoms of an illness or medical condition. ... Species see text Cytomegalovirus (CMV), is a genus of Herpes viruses; in humans the species is known as Human herpesvirus 5 (HHV-5). ... An infection is the detrimental colonization of a host organism by a foreign species. ... Jump to: navigation, search In organic chemistry and biochemistry, esters are organic compounds where an organic group (symbolised by R in this article) replaces a hydrogen atom (or more than one) in an oxygen acid. ... Ganciclovir sodium (Cytovene®) is an antiviral medication used to treat cytomegalovirus (CMV) infections. ... A prodrug is a pharmacological substance (drug) which is administered in an inactive (or significantly less active) form. ... Jump to: navigation, search The intestine is the portion of the alimentary canal extending from the stomach to the anus and, in humans and mammals, consists of two segments, the small intestine and the large intestine. ... Jump to: navigation, search The liver is an organ in vertebrates, including humans. ...

Contents


Administration

Orally, available in 450 mg pink tablets. Dosing is calculated to provide appropriate doses of ganciclovir; 900 mg of valganciclovir orally every 12 hours is equivalent to 5 mg per kilogram of body weight of intravenous ganciclovir, also every 12 hours. The hour (symbol: h) is a unit of time. ...


Pharmacokinetics

  1. Oral bioavailability is approximately 60%. Fatty foods significantly increase the bioavailability and the peak level in the serum.
  2. It takes about 2 hours to reach maximum concentrations in the serum.
  3. Valganciclovir is eliminated as ganciclovir in the urine, with a half-life of about 4 hours in people with normal kidney function.

In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Blood plasma is a component of blood. ... Jump to: navigation, search Concentration is a very common concept used in chemistry and related fields. ... Half-Life For a quantity subject to exponential decay, the half-life is the time required for the quantity to fall to half of its initial value. ... The hour (symbol: h) is a unit of time. ... Renal physiology is the study of the physiology of the kidneys. ...

Side effects

Jump to: navigation, search Red blood cells (erythrocytes) are present in the blood and help carry oxygen to the rest of the cells in the body Blood is a circulating tissue composed of fluid plasma and cells (red blood cells, white blood cells, platelets). ... Jump to: navigation, search It has been suggested that Agranulocytosis be merged into this article or section. ... This article discusses the medical condition. ... Thrombocytopenia (or -paenia, or thrombopenia in short) is the presence of relatively few platelets in blood. ... Bone marrow suppression is a serious side effect of chemotherapy and certain drugs affecting the immune system such as azathioprine. ... For the Physics term GUT, please refer to Grand unification theory The gastrointestinal or digestive tract, also referred to as the GI tract or the alimentary canal or the gut, is the system of organs within multicellular animals which takes in food, digests it to extract energy and nutrients, and... Jump to: navigation, search Diarrhea (AmE) or diarrhoea (CwE) is a condition in which the sufferer has frequent and watery or loose bowel movements (from the ancient Greek word διαρροή = leakage; lit. ... Nausea (Greek Ναυτεία) is the sensation of unease and discomfort in the stomach with an urge to vomit. ... Jump to: navigation, search A diagram showing the CNS. The central nervous system (CNS) represents the largest part of the nervous system. ... Jump to: navigation, search Hyperthermia: Characterized on the left. ... A headache (medically known as cephalalgia) is a condition of mild to severe pain in the head; sometimes upper back or neck pain may also be interpreted as a headache. ... Jump to: navigation, search For the novel by Stephen King, see Insomnia (novel); for the Norwegian movie and its American remake, see Insomnia (movie). ... Paresthesia (paraesthesia in British) is a sensation of tingling, pricking, or numbness of the skin with no apparent physical cause, more generally known as the feeling of pins and needles. ... Peripheral neuropathy is the medical term for damage to nerves of the peripheral nervous system, which may be caused either by diseases of the nerve or from the side-effects of systemic illness. ... Jump to: navigation, search This article needs to be cleaned up to conform to a higher standard of quality. ... Jump to: navigation, search Retinal detachment is a disorder of the eye in which the retina peels away from its underlying layer of support tissue. ...

References

  1. Paltiel AD et al Preevaluation of clinical trial data: the case of preemptive cytomegalovirus therapy in patients with human immunodeficiency virus. Clin Infect Dis. 2001;32(5):783-93.
  2. Pescovitz MD et al Valganciclovir results in improved oral absorption of ganciclovir in liver transplant recipients. Antimicrob Agents Chemother. 2000;44(10):2811-5.
  3. Reusser P. Antiviral therapy: current options and challenges. Schweiz Med Wochenschr. 2000;130(4):101-12.
  4. Sugawara M, Huang W, Fei YJ, et al. Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2. J Pharm Sci. 2000;89(6):781-9.


Antivirals edit
Antiherpesvirus agents edit

{Acyclovir} {Cidofovir} {Docosanol} {Famciclovir} {Foscarnet} {Fomivirsen} {Ganciclovir} {Idoxuridine} {Penciclovir} {Trifluridine} {Valaciclovir} {Valganciclovir} {Vidarabine} Wikipedia does not yet have an article with this exact name. ... Aciclovir (INN) or aciclovir (USAN), marketed as Zovirax®, is one of the main antiviral drugs. ... Jump to: navigation, search Chemical structure of cidofovir Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA synthesis. ... Jump to: navigation, search Docosanol 10% cream is a topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters). ... Ganciclovir sodium (Cytovene®) is an antiviral medication used to treat cytomegalovirus (CMV) infections. ... Jump to: navigation, search Valaciclovir (INN) or valacyclovir (USAN) is an antiviral drug used in the management of herpes simplex. ... Jump to: navigation, search Chemical structure of vidarabine Vidarabine is an anti-viral drug which is active against herpes simplex and varicella zoster viruses. ...

Antiinfluenza agents [ ]

{Amantadine} {Oseltamivir} {Rimantidine} {Zanamivir} Jump to: navigation, search Antiviral drugs are a class of medication used specifically for treating viral infections. ... Jump to: navigation, search Amantadine, 1-aminoadamantane, is an antiviral drug that was approved by the FDA in 1976 for the treatment of influenza type A in adults. ... Jump to: navigation, search Oseltamivir is an antiviral drug, a neuraminidase inhibitor used in the treatment and prophylaxis of both influenza A and influenza B. Oseltamivir was the first orally active neuraminidase inhibitor commercially developed. ... Zanamivir is a neuraminidase inhibitor used in the treatment of and prophylaxis of both influenza A and influenza B. Zanamivir was the first neuraminidase inhibitor commercially developed. ...


Antiretrovirals edit

NRTIs edit Jump to: navigation, search Antiretroviral drugs are medications for the treatment of infection by the retrovirus HIV. Different antiretroviral drugs act at various stages of the HIV life cycle. ... Jump to: navigation, search Antiretroviral drugs are medications for the treatment of infection by the retrovirus HIV. Different antiretroviral drugs act at various stages of the HIV life cycle. ...

{Zidovudine} {Didanosine} {Stavudine} {Zalcitabine} {Lamivudine} {Abacavir} Zidovudine (INN) or azidothymidine (abbreviated to AZT) is an antiretroviral drug, the first antiviral treatment to be approved for use against HIV. It is also sold under the names Retrovir and Retrovis, and as an ingredient in Combivir and Trizivir. ... Jump to: navigation, search Didanosine (2-3-dideoxyinosine, ddI, Videx®) differs from other nucleoside analogues, because it does not have any of the regular bases, instead it has hypoxanthine attached to the sugar ring. ... Jump to: navigation, search Stavudine (2-3-didehydro-2-3-dideoxythymidine, d4T, brand name Zerit®) is a thymidine analogue active against HIV. It is phosphorylated by cellular kinases into active triphosphate. ... Zalcitabine (2-3-dideoxycytidine, ddC), is a derivative of the naturally existing deoxycytidine, made by replacing the hydroxyl group in position 3 with a hydrogen. ... Lamivudine(2-3-dideoxy-3-thiacytidine, 3TC) is a potent reverse transcriptase inhibitor. ... Jump to: navigation, search Abacavir (ABC) is extremely potent reverse transcriptase inhibitor, meant for the treatment of AIDS. ABC is capable of crossing the blood-brain barrier. ...


NNRTIs edit Jump to: navigation, search Antiretroviral drugs are medications for the treatment of infection by the retrovirus HIV. Different antiretroviral drugs act at various stages of the HIV life cycle. ...

{Nevirapine} {Efavirenz} {Delavirdine} Jump to: navigation, search Nevirapine is a controversial AIDS drug. ... DESCRIPTION SUSTIVA® (efavirenz) is a human immunodeficiency virus type 1 (HIV-1) specific, non-nucleoside, reverse transcriptase inhibitor (NNRTI). ...


PIs edit Jump to: navigation, search Antiretroviral drugs are medications for the treatment of infection by the retrovirus HIV. Different antiretroviral drugs act at various stages of the HIV life cycle. ...

{Saquinavir} {Indinavir} {Atazanavir} {Ritonavir} {Nelfinavir} {Amprenavir} {Lopinavir} Saquinavir (Fortovase®, Roche) is a protease inhibitor, used as a component of HIV therapy. ... Categories: Stub ... Ritonavir is a drug from the protease inhibitor class used to treat AIDS. It is manufactured as Norvir® by Abbott Laboratories. ... Jump to: navigation, search Nelfinavir (Viracept®) is an antitretroviral drug used in the treatment of the human immunodeficiency virus (HIV). ...


Other antiviral agents edit

{Fomivirsen} {Imiquimod} {Interferon} {Lamivudine} {Ribavirin} Jump to: navigation, search Antiviral drugs are a class of medication used specifically for treating viral infections. ... Jump to: navigation, search Interferons (IFNs) are natural proteins produced by the cells of the immune systems of most animals in response to challenges by foreign agents such as viruses, bacteria, parasites and tumor cells. ... Lamivudine(2-3-dideoxy-3-thiacytidine, 3TC) is a potent reverse transcriptase inhibitor. ... Ribavirin (Copegus®; Rebetol®) is an anti-viral drug active against a number of DNA and RNA viruses. ...


  Results from FactBites:
 
valganciclovir medical facts from Drugs.com (1780 words)
Using valganciclovir while you are pregnant may cause harm to the unborn baby.
Valganciclovir is in the FDA pregnancy category C. This means that it is not known if it will be harmful to an unborn baby.
Symptoms of a valganciclovir overdose may include seizure (convulsions), kidney failure (urinating more or less than usual, blood in the urine, swelling or numbness in your hands or feet, pain in your lower back or sides), or signs of liver damage (yellowing of the skin or eyes, severe and sudden stomach pain, diarrhea, vomiting).
  More results at FactBites »

 
 

COMMENTARY     


Share your thoughts, questions and commentary here
Your name
Your comments

Want to know more?
Search encyclopedia, statistics and forums:

 


Press Releases |  Feeds | Contact
The Wikipedia article included on this page is licensed under the GFDL.
Images may be subject to relevant owners' copyright.
All other elements are (c) copyright NationMaster.com 2003-5. All Rights Reserved.
Usage implies agreement with terms, 1022, m