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Encyclopedia > Valdecoxib

Valdecoxib chemical structure
Valdecoxib Image is drawn in bkchem and GIMP. This image has been released into the public domain by the copyright holder, its copyright has expired, or it is ineligible for copyright. ...

4-(5-methyl-3-phenyl-4-isoxazolyl)-benzenesulfonamide
CAS number
181695-72-7
ATC code
M01AH03
Chemical formula C16H14N2O3S
Molecular weight 314.364
Bioavailability 83%
Metabolism 10%
Elimination half-life 8-11 hours
Excretion 90%
Pregnancy category In late pregnancy, valdecoxib should be avoided because it may cause premature closure of the ductus arteriosus.
Legal status Recalled in US, EU, Canada & parts of Asia
Routes of administration 10mg Oral
Information Source: "FDA Bextra Labeling Information (http://www.bextra.com/pdf/bextrapi.pdf)." FDA Bextra Labeling Information. Accessed on April 8, 2005.

Valdecoxib is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is classified as a nonsteroidal anti-inflammatory drug, or NSAID, and should not be taken by anyone allergic to these types of medications. CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is a term used to describe a pharmacokinetic property of drugs, namely, the fraction of a dose which reaches the systemic circulation. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... --212. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother. ... The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... April 8 is the 98th day of the year in the Gregorian calendar (99th in leap years). ... 2005 is a common year starting on Saturday of the Gregorian calendar and is the current year. ... Osteoarthritis (OA), also known as arthrosis or degenerative joint disease, is a disease featuring pain and impaired function of the joints. ... Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints. ... The menstrual cycle is the periodic change in a womans body that occurs every month between puberty and menopause and that relates to reproduction. ... Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation. ...


Valdecoxib was manufactured and marketed under the brand name Bextra® by G. D. Searle & Company. It was available by prescription in tablet form until 2005, when it was removed from the market due to concerns about possible increased risk of heart attack and stroke. 2005 is a common year starting on Saturday of the Gregorian calendar and is the current year. ... A myocardial infarction occurs when an atherosclerotic plaque slowly builds up in the inner lining of a coronary artery and then suddenly ruptures, totally occluding the artery and preventing blood flow downstream. ... A stroke or cerebrovascular accident (CVA) occurs when the blood supply to a part of the brain is suddenly interrupted by occlusion (an ischemic stroke- approximately 90%of strokes) or by hemorrhage (a hemorrhagic stroke - approximately 10% of strokes). ...

Contents

Uses

Since its registration, Bextra was prescribed for pain associated with arthritis, menstrual discomfort, and other ailments. Arthritis (from Greek arthro-, joint + -itis, inflammation) is a group of conditions that affect the health of the bone joints in the body. ... Dysmenorrhea (or dysmenorrhoea), cramps or painful menstruation, involves menstrual periods that are accompanied by either sharp, intermittent pain or dull, aching pain, usually in the pelvis or lower abdomen. ...


Side-effects and withdrawal

On April 7, 2005, Pfizer withdrew Bextra from the US market on recommendation by the FDA, citing an increased risk of heart attack and stroke and also the risk of a serious, sometimes fatal, skin reaction. This was a result of recent attention to prescription NSAIDs, such as Merck's Vioxx. Other reported side-effects were angina and Stevens-Johnson syndrome. A myocardial infarction occurs when an atherosclerotic plaque slowly builds up in the inner lining of a coronary artery and then suddenly ruptures, totally occluding the artery and preventing blood flow downstream. ... A stroke or cerebrovascular accident (CVA) occurs when the blood supply to a part of the brain is suddenly interrupted by occlusion (an ischemic stroke- approximately 90%of strokes) or by hemorrhage (a hemorrhagic stroke - approximately 10% of strokes). ... Merck & Co. ... Rofecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that was used in the treatment of osteoarthritis, acute pain conditions, and dysmenorrhoea. ... Angina pectoris (Latin for chest constriction) is the result of a lack of oxygen supply to the heart muscle, due to a reduced blood flow around the hearts blood vessels. ... Stevens-Johnson syndrome (SJS) is a severe and potentially life-threatening (15% of cases) disease, it is a hypersensitivity complex affecting the skin and the mucous membranes, a severe expression of erythema multiforme (EM) (and so SJS is also called erythema multiforme major). ...


Pfizer first acknowledged cardiovascular risks associated with Bextra in October of 2004. The American Heart Association soon after was presented with a report indicating patients using Bextra while recovering from heart surgery were 2.19 times more likely to suffer a stroke or heart attack than those taking placebos.


Personal injury

With the removal of the drug from the market, there is expected to be a surge in personal injury claims, many in the form of class action, to seek compensation. In law, a class action is an equitable procedural device used in litigation for determining the rights of and remedies, if any, for large numbers of people whose cases involve common questions of law and fact. ...


External link

  • FDA Alert on Bextra withdrawal (http://www.fda.gov/cder/drug/InfoSheets/HCP/valdecoxibHCP.htm)

  Results from FactBites:
 
Valdecoxib - definition of Valdecoxib in Encyclopedia (101 words)
Valdecoxib is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms.
It is classified as a nonsteroidal anti-inflammatory drug, or NSAID, and should not be taken by anyone allergic to these types of medications.
Valdecoxib is manufactured and marketed under the brand name Bextra® by G. Searle and Company.
valdecoxib (Bextra) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com (812 words)
Valdecoxib also is approved for the relief of pain of menstrual cramps (primary dysmenorrhea).
Valdecoxib may be taken with or without food.
Valdecoxib should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
  More results at FactBites »

 
 

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