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Encyclopedia > VDRL

VDRL is a four-letter abbreviation that can refer to Veneral Disease Research Laboratory. The VDRL is a nontreponemal serological screening for syphilis, the monitoring of the response to therapy, the detection of CNS involvement, and as an aid in the diagnosis of congenital syphilis. Syphilis (historically called lues) is a sexually transmitted disease (STD) that is caused by a spirochaete bacterium, Treponema pallidum. ...

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Definition of Venereal Disease Research Laboratory test

Venereal Disease Research Laboratory test: A blood test for syphilis. Venereal Disease Research Laboratory is commonly abbreviated VDRL.

A negative ("nonreactive") VDRL is compatible with a person not having syphilis. However, a person may a negative VDRL and still have syphilis since, in the early stages of the disease, the VDRL often gives negative results. This is called a false negative VDRL.

The VDRL test is sometimes positive in the absence of syphilis. For example, a false positive VDRL can be encountered in infectious mononucleosis, lupus, the antiphospholipid antibody syndrome, hepatitis A, leprosy, malaria and, occasionally, pregnancy.

The RPR (rapid plasma reagin) test is similar to the VDRL test. It is also designed to detect an antibody substance in the bloodstream when syphilis is present but, as with the VDRL, early syphilis infections may give a false negative RPR result. The RPR, like the VDRL, can also give false positive results.

Common Misspellings: venereal diease research laboratory test, venereal desease research laboratory test

  Results from FactBites:
MedlinePlus Medical Encyclopedia: VDRL (628 words)
VDRL is a screening test for syphilis that measures antibodies that can be produced by Treponema pallidum, the bacteria that causes syphilis.
If an individual is suspected of having brain involvement with syphilis (neurosyphilis), the VDRL test may be performed on spinal fluid.
The VDRL test's ability to detect syphilis depends on the stage of the disease.
BD - Diagnostic Systems: VDRL Test Control Serum Set (1239 words)
The VDRL Antigen is a nontreponemal antigen composed of cardiolipin cholesterol and lecithin.
VDRL Antigen is 0.03% cardiolipin and 0.9% cholesterol dissolved in absolute alcohol with sufficient lecithin (approximately 0.18 – 0.20%) to produce standard reactivity.
VDRL Weakly Reactive Serum is a lyophilized human serum with 0.02% thimerosal as a preservative which is standardized to provide a weakly reactive reading when tested according to the VDRL test procedure.
  More results at FactBites »



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