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Encyclopedia > UGT2B7

UGT2B7 (UDP-Glucuronosyltransferase-2B7) is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain. Overview of the citric acid cycle The citric acid cycle, one of the central metabolic pathways in aerobic organisms. ... Isozymes, (or isoenzymes) are isoforms (closely related variants) of enzymes. ... The liver is an organ in some animals, including vertebrates (and therefore humans). ... It has been suggested that Renal anomalies and Renal plasma threshold be merged into this article or section. ... Types of epithelium This article discusses the epithelium, an animal anatomical structure. ... The gastrointestinal tract (GI tract), also called the digestive tract, alimentary canal, or gut, is the system of organs within multicellular animals that takes in food, digests it to extract energy and nutrients, and expels the remaining waste. ... In animals, the brain, or encephalon (Greek for in the head), is the control center of the central nervous system. ...


This enzyme is located on the endoplasmic reticulum and nuclear membranes of cells. Its function is to catalyse the conjugation of a wide variety of lipophilic aglycon substrates with glucuronic acid, using uridine diphosphate glucuronic acid. The endoplasmic reticulum (endoplasmic meaning within the cytoplasm, reticulum meaning little net in Latin) or ER is an organelle found in all eukaryotic cells that is an interconnected network of tubules, vesicles and cisternae that is responsible for several specialized functions: Protein translation, folding, and transport of proteins (e. ... The nuclear envelope (also known as the perinuclear envelope, nuclear membrane, nucleolemma or karyotheca) is the double membrane of the nucleus that encloses genetic material in eukaryotic cells. ... In chemistry and biology, catalysis is the acceleration (increase in rate) or slowing down of a chemical reaction by means of a substance, called a catalyst, that is itself not consumed by the overall reaction. ... The α-D form of glucuronic acid. ...


UGT2B7 is the major enzyme isoform for the metabolism of Morphine to the main metabolites, morphine-3- (M3G) and morphine-6-glucuronide (M6G). Morphine (INN) (IPA: ) is a highly potent opiate analgesic drug and is the principal active agent in opium and the prototypical opiate. ...


References

    Coffman et al. (1997) Human UGT2B7 Catalyzes Morphine Glucuronidation. Drug Metabolism and Disposition. 25 (1). Available online at: http://dmd.aspetjournals.org/cgi/content/abstract/25/1/1


    http://www.pharmgkb.org/do/serve?objId=PA361


     
     

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