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Encyclopedia > Translational research

Translational medicine is a branch of medical research that attempts to more directly connect basic research to patient care. Translational medicine is growing in importance in the healthcare industry, and is a term whose precise definition is in flux. In particular, drug discovery and development, translational medicine typically refers to the "translation" of basic research into real therapies for real patients. The emphasis is on the linkage between the laboratory and the patient's bedside, without a real disconnect. This is often called the "bench to bedside" definition. Medical research (or experimental medicine) is basic research and applied research conducted to aid the body of knowledge in the field of medicine. ... In the various subfields of physics, there exist two common usages of the term flux, both with rigorous mathematical frameworks. ... Oral medication Caffeine is the most widely used psychoactive substance in the world. ... Pediatric polysomnography patient Childrens Hospital (Saint Louis), 2006 A patient or invalid is any person who receives medical attention, care, or treatment. ...

Translational medicine can also have a much broader definition, referring to the development and application of new technologies in a patient driven environment - where the emphasis is on early patient testing and evaluation. In modern healthcare, we are seeing a move to a more open, patient driven research process, and the embrace of a more research driven clinical practice of medicine. Health care or healthcare is one of the worlds largest and fastest growing professions. ...

Many pharmaceutical companies are building translational medicine groups to facilitate the interaction between basic research and clinical medicine, particularly in clinical trials. Traditionally, basic research has been separated from the clinical practice of medicine by a series of hurdles or fences. New drugs were developed independently of the clinic, and often "thrown over the fence" for safety testing and clinical trials. The move toward translational medicine is focused on removing these fences, and stimulating "bench to bedside" research. A pharmaceutical company is a licensed drug company, licensed to discover, develop, markets and distribute drugs. ... In medicine, a clinical trial (synonyms: clinical studies, research protocols, medical research) is a type of research study. ... A clinic or outpatient clinic is a small medical facility that provides health care for ambulatory patients - as opposed to inpatients treated in a hospital. ...

See also

The goal of predictive medicine is to identify biological markers in order to enrole individuals at high risk for developing a disease in special early detection trials. ... // Introduction The feild of molecular imaging origanated from the feild of radiopharmacology due to the need to better understand the underlieing molecular pathways inside organisms in a noninvasiveway. ...


  • Letter Philip Pizzo, MD - Dean, Stanford School of Medicine
  • Geraghty J., Adenomatous polyposis coli and translational medicine, Lancet. 1996 Aug 17;348(9025):422.
  • Marincola FM., Translational Medicine: A two-way road, J Transl Med. 2003 Jul 24;1(1):1.
  • Stacey P Mankoff, Christian Brander, Soldano Ferrone, and Francesco M Marincola, Lost in Translation: Obstacles to Translational Medicine, J Transl Med. 2004; 2: 14.



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