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Encyclopedia > Transjugular intrahepatic portosystemic shunt

A transjugular intrahepatic portosystemic shunt, also TIPS, is an artificial channel in the liver from the portal vein to a hepatic vein (for blood). It is created endovascularly (via the blood vessels) by physicians via the jugular vein. A shunt in general is a sort of relief valve, or diverter. ... The liver is the largest internal organ of the human body. ... The portal vein is a major vein in the human body draining blood from the digestive system and its associated glands. ... Superior vena cava, inferior vena cava (IVC), azygos vein and their tributaries. ... Human blood smear: a - erythrocytes; b - neutrophil; c - eosinophil; d - lymphocyte. ... The arterial system The blood vessels are part of the circulatory system and function to transport blood throughout the body. ... Physician examining a child A physician is a person who practices medicine. ... Jugular vein - Wikipedia, the free encyclopedia /**/ @import /skins-1. ...

It is used to treat portal hypertension (which often is due to scarring of the liver (liver cirrhosis)) which frequently leads to bleeding esophageal varices. In medicine, portal hypertension is hypertension (high blood pressure) in the portal vein and its branches. ... Cirrhosis is a chronic disease of the liver in which liver tissue is replaced by connective tissue, resulting in the loss of liver function. ... In medicine (gastroenterology), esophageal varices are extreme dilations of sub mucosal veins in the mucosa of the esophagus in diseases featuring portal hypertension, secondary to cirrhosis primarily. ...


Mechanism of action

A TIPS decreases the effective vascular resistance of the liver. The result is a reduced pressure drop over the liver and a decreased portal venous pressure. Vascular resistance is a term used to define the resistance to flow that must be overcome to push blood through the circulatory system. ...

Use in hepatorenal syndrome

TIPS has shown some promise for patients with hepatorenal syndrome.[1] Hepatorenal syndrome (HRS) is liver failure that results in concomitant renal failure. ...

See also

In human anatomy, the portal venous system is the system of veins that drain into the portal vein. ... In medicine, a distal splenorenal shunt procedure (DSRS), also splenorenal shunt procedure and Warren shunt,[1] is a surgical procedure in which the distal splenic vein (a part of the portal venous system) is attached to the left renal vein (a part of the systemic venous system). ...


  1. ^ Guevara M, Rodes J. Hepatorenal syndrome. Int J Biochem Cell Biol. 2005 Jan;37(1):22-6. PMID 15381144.

External links

  • Transjugular Intrahepatic Portosystemic Shunt - eMedicine.com.
  • A schematic representation of a TIPS - University of Michigan.

  Results from FactBites:
Transjugular Intrahepatic Portosystemic Shunt (TIPS) (794 words)
The transjugular intrahepatic portosystemic shunt (TIPS) procedure is performed percutaneously through the jugular vein and involves the creation of a permanent intrahepatic shunt between the hepatic and portal veins, easing portal hypertension.
Transjugular intrahepatic portosystemic shunt (TIPS) was originally created as a bridge to liver transplantation.
Transjugular intrahepatic portosystemic shunt compared with endoscopic treatment for prevention of variceal rebleeding: a meta-analysis.
Transjugular intrahepatic portosystemic shunt (TIPS) versus endoscopic variceal ligation in the prevention of variceal ... (4111 words)
Transjugular intrahepatic portosystemic shunt (TIPS) versus endoscopic variceal ligation in the prevention of variceal rebleeding in patients with cirrhosis: a randomised trial
Transjugular intrahepatic portacaval stent shunt as a rescue treatment for life threatening variceal bleeding in a cirrhotic patient with severe liver failure.
Transjugular intrahepatic portosystemic shunt versus endoscopic sclerotherapy for the prevention of variceal bleeding in cirrhosis: a randomized multicenter trial.
  More results at FactBites »



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