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Encyclopedia > Transfusion reaction

Transfusion reactions occur after blood product transfusions when there is an interaction between the recipient and the donor blood. In addition to infections such as HIV and hepatitis, transfusions may result in fever, destruction of red blood cells (hemolysis) and allergic reactions. Less common but more serious reactions include transfusion related acute lung injury, transfusion-associated graft versus host disease, alloimmunization, and transfusion-related immunomodulation.[1] Blood transfusion is the taking of blood or blood-based products from one individual and inserting them into the circulatory system of another. ... Human immunodeficiency virus (commonly known as HIV, and formerly known as HTLV-III and lymphadenopathy-associated virus) is a retrovirus that is the cause of the disease known as AIDS, or Acquired Immunodeficiency Syndrome, a syndrome where the immune system begins to fail, leading to many life-threatening opportunistic infections. ... Hepatitis is a gastroenterological disease, featuring inflammation of the liver. ... Hemolysis (alternative spelling haemolysis) literally means the excessive breakdown of red blood cells. ... An allergy can refer to several kinds of immune reactions including Type I hypersensitivity in which a persons body is hypersensitised and develops IgE type antibodies to typical proteins. ... Transfusion-associated graft versus host disease (TA-GvHD) is a rare complication of blood transfusion, in which the donor T lymphocytes mount an immune response against the recipients lymphoid tissue. ... Alloimmunity is a condition in which the body gains immunity against cells from another individual of the same species. ...

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See also

ICD-10 Chapter T: World health Organisation classification - Complications following infusion, transfusion and therapeutic injection // S00-T98 - Injury, poisoning and certain other consequences of external causes (S00-S09) Injuries to the head (S00) Superficial injury of head (S01) Open wound of head (S02) Fracture of skull and facial bones (S03) Dislocation, sprain and strain of joints and ligaments of head (S04) Injury of cranial nerves...


  1. ^ Goodnough LT, Brecher ME, Kanter MH, AuBuchon JP. Transfusion medicine. First of two parts--blood transfusion. N Engl J Med. 1999 Feb 11;340(6):438-47. Review. PMID 9971869
Transfusion medicine - edit
Blood transfusion | Cross-matching | Coombs test | Intraoperative blood salvage | Transfusion reactions | International Society of Blood Transfusion | ISBT 128 | Platelet transfusion |
Human blood group systems - Blood type
ABO | Rhesus | Duffy | Hh | Kell | Kidd | Kx | Colton | Yt
Blood products
Blood donation | Blood | Plasma | Platelets | Cryoprecipitate | Plasmapheresis | Red blood cells 

  Results from FactBites:
The evaluation of all adverse reactions to transfusion is the responsibility of the medical staff of the Blood Bank and the notification of such a reaction by the patient unit serves as a request for Blood Bank physician consultation.
Reactions may be separated into reactions that present in proximity to the transfusion and those that present at some time subsequent to the transfusion.
Supplemental transfusion of blood lacking the antigen corresponding to the offending antibody may be necessary to compensate for the transfused cells that have been removed from the circulation.
  More results at FactBites »



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