In blood coagulation, tissue plasminogen activator (tPA) is an enzyme (EC188.8.131.52 (http://www.expasy.org/cgi-bin/nicezyme.pl?184.108.40.206)) that activates plasminogen, leading to fibrinolysis. The coagulation of blood is a complex process during which blood forms solid clots. ... Neuraminidase ribbon diagram An enzyme (in Greek en = in and zyme = leaven) is a protein, or protein complex, that catalyzes a chemical reaction and also controls the 3D orientation of the catalyzed substrates. ... EC numbers (Enzyme Commission numbers) are a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. ... Plasmin is an important degrading enzyme (EC 3. ... Fibrinolysis is the process where a fibrin clot, the product of coagulation, is broken down. ...
Recombinant tPA is used in diseases which feature blood clots, such as myocardial infarction and stroke. To be effective, tPA must be administered within the first six or so hours of the attack. Because of this, only about 3% of patients qualify for this treatment. Since tPA dissolves blood clots, there is risk of hemorrhage with its use. Recombinant proteins are proteins that are produced by different genetically modified organisms following insertion of the relevant DNA into their genome. ... A myocardial infarction occurs when an atherosclerotic plaque slowly builds up in the inner lining of a coronary artery and then suddenly ruptures, totally occluding the artery and preventing blood flow downstream. ... A stroke or cerebrovascular accident (CVA) occurs when the blood supply to a part of the brain is suddenly interrupted by occlusion (an ischemic stroke- approximately 90%of strokes) or by hemorrhage (a hemorrhagic stroke - approximately 10% of strokes). ... A thrombus is the final product of blood coagulation, through the aggregation of platelets and the activation of the humoral coagulation system. ... Hemorrhage (alternate spelling is Haemorrhage) is the medical term meaning bleeding. ...
Tissueplasminogenactivator (tPA) is a serine protease involved in the degradation of blood clots through the activation of plasminogen to plasmin.
The identification of tPA as an activator of PDGF signaling establishes a novel role for the protease in normal and pathological tissue growth and maintenance, distinct from its well-known role in plasminogenactivation and fibrinolysis.
In tumor tissue sections, PDGF-C expression was observed mostly in tumor cells located at the center of the tumor in close apposition to larger blood vessels, while tPA was mainly expressed in the endothelium of the tumor blood vessels (Figure 7E and F).
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