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Encyclopedia > Tissue factor pathway inhibitor

Tissue Factor Pathway Inhibitor (or TFPI) is a protein that can reversibly inhibit Factor Xa (Xa), and after it has inhibted Xa, the Xa-TFPI complex can then inhibit the FVIIa-TF complex. Factor X, also known by the eponym Stuart-Prower factor or as thrombokinase, is an enzyme ( EC 3. ... Factor VII (old name proconvertin) is one of the central proteins in the coagulation cascade. ... Thromboplastin is a substance present in tissues, platelets, and leukocytes necessary for the coagulation of blood; in the presence of calcium ions thromboplastin is necessary for the conversion of prothrombin to thrombin, an important step in coagulation of blood. ...


See Also

hemostasis Hemostasis refers to a process whereby bleeding is halted in most animals with a closed circulatory system. ...



Cardiovascular system - Blood
Red blood cells - White blood cells - Platelets - Blood plasma - Pluripotential hemopoietic stem cell
White blood cells
Granulocytes (Neutrophil granulocytes, Eosinophil granulocytes, Basophil granulocytes) - Lymphocytes - Monocytes
Coagulation
Coagulation factors: - Fibrin (I) - (Pro)thrombin (II) - FV - FVII - FVIII - FIX - FX - FXI - FXII - FXIII - HMWK - vWF - Tissue factor
Inhibitors: Antithrombin - Protein C - Protein S - Protein Z - ZPI - TFPI
Fibrinolysis: Plasmin - tPA/urokinase - PAI-1/2 - α2-AP - TAFI

  Results from FactBites:
 
Society of Cardiovascular Anesthesiologists (1020 words)
TF pathway inhibitor-1 (TFPI-1) is the principal endogenous inhibitor of the TF pathway.11 It is produced by vascular endothelial cells as well as mesangial cells, smooth muscle cells, monocytes, fibroblasts, and cardiomyocytes.
Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal Escherichia coli sepsis.
Role of tissue factor and factor VIIa in the coagulant and inflammatory response to LD100 Escherichia coli in the baboon.
biology - Coagulation (1874 words)
The pathways are a series of reactions, in which a zymogen of a serine protease and its glycoprotein co-factor are activated to become active components that then catalyze the next reaction in the cascade.
Following activation by the contact factor or tissue factor pathways the coagulation cascade is maintained in a prothrombotic state by the continued activation of FVIII and FIX to form the tenase complex, until it is down regulated by the anticoagulant pathways.
If a coagulation factor is part of the contact or tissue factor pathway, a deficiency of that factor will affect only one of the tests: thus hemophilia A, a deficiency of factor VIII, which is part of the contact factor pathway, results in an abnormally prolonged aPTT test but a normal PT test.
  More results at FactBites »

 
 

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