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Encyclopedia > Tipranavir

Tipranavir is a new protease inhibitor (PI) that was approved by the FDA in June 2005. It has the ability to inhibit the replication of viruses which are resistant to other availabe protease inhibitors. Resistance to tipranivir itself seems to require multiple mutations[1]. As for other drugs, combination therapy is used; tipranavir is given in combination with Ritonavir 200 mg twice daily. Protease inhibitors are a class of medication used to treat or prevent viral infections. ... The United States Food and Drug Administration (FDA) is the government agency responsible for regulating food (human and animal), dietary supplements, drugs (human and animal), cosmetics, medical devices (human and animal), biologics and blood products in the United States. ... 2005 : January - February - March - April - May - June - July - August - September - October - November - December- → Deaths in June June 27: Shelby Foote June 27: John T. Walton June 26: Richard Whiteley June 25: John Fiedler June 25: Chet Helms June 24: Paul Winchell June 21: Jaime Cardinal Sin June 20: Jack Kilby... The HIV virus A virus is a microscopic parasite that infects cells in biological organisms. ... Antiretroviral drugs are medications for the treatment of infection by the retrovirus HIV. Different antiretroviral drugs act at various stages of the HIV life cycle. ... Ritonavir is a drug from the protease inhibitor class used to treat AIDS. It is manufactured as Norvir® by Abbott Laboratories. ...


References

  • ^  Selection and characterization of HIV-1 showing reduced susceptibility to the non-peptidic protease inhibitor tipranavir


Antiretrovirals edit

NRTIs edit Antiretroviral drugs are medications for the treatment of infection by the retrovirus HIV. Different antiretroviral drugs act at various stages of the HIV life cycle. ... Antiretroviral drugs are medications for the treatment of infection by the retrovirus HIV. Different antiretroviral drugs act at various stages of the HIV life cycle. ...

{Zidovudine} {Didanosine} {Stavudine} {Zalcitabine} {Lamivudine} {Abacavir} Zidovudine (INN) or azidothymidine (abbreviated to AZT) is an antiretroviral drug, the first antiviral treatment to be approved for use against HIV. It is also sold under the names Retrovir and Retrovis, and as an ingredient in Combivir and Trizivir. ... Didanosine (2-3-dideoxyinosine, ddI, Videx®) differs from other nucleoside analogues, because it does not have any of the regular bases, instead it has hypoxanthine attached to the sugar ring. ... Stavudine (2-3-didehydro-2-3-dideoxythymidine, d4T, brand name Zerit®) is a thymidine analogue active against HIV. It is phosphorylated by cellular kinases into active triphosphate. ... Zalcitabine (2-3-dideoxycytidine, ddC), is a derivative of the naturally existing deoxycytidine, made by replacing the hydroxyl group in position 3 with a hydrogen. ... Lamivudine (2,3-dideoxy-3-thiacytidine, 3TC) is a potent reverse transcriptase inhibitor. ... Abacavir (ABC) is extremely potent reverse transcriptase inhibitor, meant for the treatment of AIDS. ABC is capable of crossing the blood-brain barrier. ...


NNRTIs edit Antiretroviral drugs are medications for the treatment of infection by the retrovirus HIV. Different antiretroviral drugs act at various stages of the HIV life cycle. ...

{Nevirapine} {Efavirenz} {Delavirdine} Nevirapine is a controversial AIDS drug. ... This article needs to be cleaned up to conform to a higher standard of quality. ...


PIs edit Antiretroviral drugs are medications for the treatment of infection by the retrovirus HIV. Different antiretroviral drugs act at various stages of the HIV life cycle. ...

{Saquinavir} {Indinavir} {Atazanavir} {Ritonavir} {Nelfinavir} {Amprenavir} {Lopinavir} {Tipranavir} Saquinavir (Fortovase®, Roche) is a protease inhibitor, used as a component of HIV therapy. ... Categories: Stub ... Ritonavir is a drug from the protease inhibitor class used to treat AIDS. It is manufactured as Norvir® by Abbott Laboratories. ... Nelfinavir (Viracept®) is an antitretroviral drug used in the treatment of the human immunodeficiency virus (HIV). ...


  Results from FactBites:
 
Tipranavir: An Overview (1191 words)
Studies of tipranavir use in children and infants aged 2-18 years are currently underway.
Tipranavir resistance was detected at virologic rebound after an average of 38 weeks of tipranavir/ritonavir treatment with a median 14-fold decrease in tipranavir susceptibility.
Simultaneous Quantification of the New HIV Protease Inhibitors Atazanavir and Tipranavir
Tipranavir New Drug Approval Tipranavir (613 words)
Tipranavir is a non-peptidic protease inhibitor under investigation for the treatment of HIV-1 infection in combination with other antiretroviral agents.
Tipranavir is a non-peptidic protease inhibitor currently in late Phase 3 clinical development -- the final stage of testing prior to the submission of data to the FDA for review for marketing approval.
Tipranavir is also being evaluated for use in pediatric and treatment-naïve patient populations in Phase 2 and 3 studies that are currently underway.
  More results at FactBites »

 
 

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