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Encyclopedia > Thyroxine
Thyroxine
Identifiers
CAS number [7488-70-2]
PubChem 853
MeSH Thyroxine
SMILES NC(Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
Properties
Molecular formula C15H11I4NO4
Molar mass 776.87
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Thyroxine, or 3:5,3':5' tetra­iodothyronine (often abbreviated as T4) is the major hormone secreted by the follicular cells of the thyroid gland. Image File history File links Size of this preview: 800 × 508 pixel Image in higher resolution (1100 × 698 pixel, file size: 36 KB, MIME type: image/png) File links The following pages on the English Wikipedia link to this file (pages on other projects are not listed): Thyroxine Thyroid hormone... Image File history File links Size of this preview: 800 × 558 pixel Image in higher resolution (1100 × 767 pixel, file size: 174 KB, MIME type: image/png) File links The following pages on the English Wikipedia link to this file (pages on other projects are not listed): Thyroxine Thyroid hormone... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... PubChem is a database of chemical molecules. ... Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. ... The simplified molecular input line entry specification or SMILES is a specification for unambiguously describing the structure of chemical molecules using short ASCII strings. ... This article or section does not cite any references or sources. ... Molar mass is the mass of one mole of a chemical element or chemical compound. ... In chemistry, the standard state of a material is its state at 1 bar (100 kilopascals) and 25 degrees Celsius (298. ... Norepinephrine A hormone (from Greek όρμή - to set in motion) is a chemical messenger from one cell (or group of cells) to another. ... Section of thyroid gland of sheep. ...


T4 is transported in blood, with 99.95% of the secreted T4 being protein bound, principally to thyroxine ­binding globulin (TBG) and to a lesser extent to transthyretin and serum albumin. Thyroxine-binding globulin (TBG) is one of three proteins (along with transthyretin and albumin) responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3’-triiodothyronine (T3) in the bloodstream. ... Transthyretin (TTR) is a serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine (T4). ... You may be looking for albumen, or egg white. ...


T4 is involved in controlling the rate of metabolic processes in the body and influencing physical development.


Note: Thyroxine is a prohormone and a reservoir for the active thyroid hormone triiodothyronine (T3), T4 being converted as required in the tissues by deiodinases. A prohormone is a chemical compound that is a precursor to an actual hormone (usually an anabolic like testosterone or some variant), which is taken in order to boost the body’s available hormone supply. ... The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are tyrosine-based hormones produced by the thyroid gland. ... Deiodinase (eg. ...


Type II deiodinase converts T4 into T3. Deiodinase (eg. ...


The "D" isomer is called "Dextrothyroxine"[1] and is used as a lipid modifying agent.[2]


Reactions

Synthesis
Synthesis

Image File history File links No higher resolution available. ... Image File history File links No higher resolution available. ...

References

  1. ^ MeSH Dextrothyroxine
  2. ^ C10AX01

  Results from FactBites:
 
L-Thyroxine (800 words)
Thyroxine - T4 By the mid- to late- nineteenth century, scientists had already noted that iodide taken into the bloodstream was concentrated in the thyroid.
Biological metabolism of thyroxine (deiodination, deamination, and increasing the solubility of the phenol through oxidation and conjugation with glucuronic acid and with sulfate) occurs mostly in the liver.
Thyroxine is also used in the treatment of patients suffering from cancer of the thyroid.
thyroxine. The Columbia Encyclopedia, Sixth Edition. 2001-05 (223 words)
Thyroxine increases the number and activity of mitochondria in cells by binding to the cells’ DNA, increasing the basal metabolic rate.
Thyroxine activity is controlled by thyrotropin, a substance released from the pituitary gland.
Synthetically prepared thyroxine is used clinically in the treatment of thyroid gland deficiency diseases in adults and in the treatment of cretinism in children.
  More results at FactBites »

 
 

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