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Encyclopedia > Thymopoietin
thymopoietin
Identifiers
Symbol TMPO
HUGO 11875
Entrez 7112
OMIM 188380
RefSeq NM_003276
UniProt P42166
Other data
Locus Chr. 12 q22

Thymopoietin is a protein involved in the induction of CD90 in the thymus. The thymopoetin (TMPO) gene encodes three alternatively splices mRNAs encoding proteins of 75 kDa (alpha), 51 kDa (beta) and 39 kDa (gamma)which are ubiquitously expressed in all cells. The human TMPO gene maps to chromosome band 12q22 and consists of eight exons. TMPO alpha is present diffusely expressed with the cell nucleus while TMPO beta and gamma are localized to the nuclear membrane. TMPO beta is a human homolog of the murine protein LAP2 (lamina-associated polypeptide 2). LAP2 plays a role in the regulation of nuclear architecture by binding lamin B1 and chromosomes. This interaction is regulated by phosphorylation during mitosis. Given the nuclear localization of the three TMPO isoforms, it is unlikely that these proteins play any role in CD90 induction. Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Short and long arms Chromosome. ... Chromosome 12 is one of the 23 pairs of chromosomes in humans. ... Thymus, see Thyme. ...


References

  • Harris, C.A., Andryuk, P.J., Cline, S.W., Mathew, S., Siekierka, J.J. and Goldstein, G. Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2. (1995) Genomics. 28:198, 1995.

  Results from FactBites:
 
Patent 4077949: Polypeptide hormones of the thymus (7507 words)
The Thymopoietin products are useful in many areas and are particularly characterized by their ability in subanogram concentrations to induce bone marrow cells to develop the characteristics of intrathymic lymphocytes and thus are of assistance in the immunity functions of the body.
Both Thymopoietin I and Thymopoietin II exhibit neuromuscular blocking activity and were found associated with material which strained with Coomassie blue, and had relative mobilities (RF) of about 0.30 with respect to bromphenol blue at a pH of 8.9 on 7% polyacrylamide gel disc electrophoresis.
The relative mobilities of Thymopoietin I and Thymopoietin II are shown in FIGS.
Patent 5472856: Recombinant human thymopoietin proteins and uses therefor (7584 words)
A polynucleotide sequence encoding a thymopoietin protein, said sequence isolated from the cellular material with which it is naturally associated, which is selected from the group consisting of SEQ ID NO: 3 and a sequence complementary thereto.
A polynucleotide sequence encoding a thymopoietin protein, said sequence isolated from the cellular material with which it is naturally associated, which is selected from the group consisting of SEQ ID NO: 5 and a sequence complementary thereto.
Thymopoietin is a polypeptide produced by cells of the thymus and other cells, which has been implicated in various immune and nervous system pathways.
  More results at FactBites »

 
 

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