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Encyclopedia > Threose nucleic acid

TNA is threose nucleic acid, a chemical similar to DNA or RNA but differing in the composition of its "backbone." TNA is not known to occur naturally in existing life on Earth. Fischer projection of D-threose D-Threose is a tetrose carbohydrate with the chemical formula C4H8O4. ... The general structure of a section of DNA Deoxyribonucleic acid (DNA) is a nucleic acid that contains the genetic instructions for the biological development of a cellular form of life or a virus. ... Ribonucleic acid (RNA) is a nucleic acid polymer consisting of nucleotide monomers. ...


DNA and RNA have a deoxyribose and ribose sugar backbone, respectively, whereas TNA's backbone is composed of repeating threose units linked by peptide bonds. The threose molecule is easier to assemble than ribose making it a possible precursor to RNA. Deoxyribose Deoxyribose, also known as D-Deoxyribose and 2-deoxyribose, is an aldopentose — a monosaccharide containing five carbon atoms, and including an aldehyde functional group. ... Ribose Ribose, primarily seen as D-ribose, is an aldopentose — a monosaccharide containing five carbon atoms, and including an aldehyde functional group. ... A peptide bond is a chemical bond formed between two molecules when the carboxyl group of one molecule reacts with the amino group of the other molecule, releasing a molecule of water (H2O). ...


DNA TNA hybrid chains have been made in the laboratory using DNA polymerase.

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External links

  • Was simple TNA the first nucleic acid on Earth to carry a genetic code? - New scientist
  • ORIGIN OF LIFE: A Simpler Nucleic Acid - Leslie Orgel
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Leslie Eleazer Orgel (born Jan 12, 1927 in London) is a chemist. ...

References

  • Orgel, Leslie (Nov 2000). "A Simpler Nucleic Acid". Science 290 (5495): 1306 - 1307. DOI:10.1126/science.290.5495.1306.
  • Watt, Gregory (Feb 2005). "Modified nucleic acids on display". Nature Chemical Biology. DOI:10.1038/nchembio005.
  • Schoning, K, Scholz P; Guntha S; Wu X; Krishnamurthy R; Eschenmoser A (Nov 2000). "Chemical etiology of nucleic acid structure: the alpha-threofuranosyl-(3'->2') oligonucleotide system.". Science. PMID 11082060.


Science is the journal of the American Association for the Advancement of Science (AAAS). ... A digital object identifier (or DOI) is a permanent identifier (permalink) given to a World Wide Web file or other Internet document so that if its Internet address changes, users will be redirected to its new address. ... A digital object identifier (or DOI) is a permanent identifier (permalink) given to a World Wide Web file or other Internet document so that if its Internet address changes, users will be redirected to its new address. ... Science is the journal of the American Association for the Advancement of Science (AAAS). ...

Nucleic acids and Oligonucleotides edit
Nucleobases: Adenine | Thymine | Uracil | Guanine | Cytosine | Purine | Pyrimidine
Nucleosides: Adenosine | Uridine | Guanosine | Cytidine | Deoxyadenosine | Thymidine | Deoxyguanosine | Deoxycytidine
Nucleotides: AMP | UMP | GMP | CMP | ADP | UDP | GDP | CDP | ATP | UTP | GTP | CTP | cAMP | cGMP
Deoxynucleotides: dAMP | TMP | dGMP | dCMP | dADP | TDP | dGDP | dCDP | dATP | TTP | dGTP | dCTP
Ribonucleic acids: RNA | mRNA | tRNA | rRNA | ncRNA | sgRNA | shRNA | siRNA | snRNA | miRNA | snoRNA | LNA
Deoxyribonucleic acids: DNA | mtDNA | cDNA | plasmid | Cosmid | BAC | YAC | HAC
Analogues of nucleic acids: GNA | PNA | TNA| morpholino
←Amino acids Major families of biochemicals Carbohydrates→

 
 

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