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Encyclopedia > Tenofovir

Tenofovir disoproxil fumarate belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (NtRTIs), which block reverse transcriptase, an enzyme crucial to viral production in HIV-infected people. It is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults. This indication is based on analyses of plasma HIV-1 RNA levels and CD4 cell counts in controlled studies of tenofovir in treatment-na´ve and treatment-experienced adults. There are no study results demonstrating the effect of tenofovir on clinical progression of HIV.


Tenofovir is marketed by Gilead Sciences with the brand name Viread. It was approved by the U.S. Food and Drug Administration (FDA) on July 2, 2003. It is also available combined with emtricitabine in a product with the brand name Truvada, approved on August 2, 2004 for once-a-day dosing.


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HBV/HIV Coinfection & Tenofovir (3282 words)
Substudies of the safety and efficacy of tenofovir disoproxil fumarate (tenofovir DF) for patients coinfected with HIV and HBV were undertaken within 2 phase 3 randomized controlled trials involving antiretroviral therapy--experienced (study 907) and --naive (study 903) HIV-infected populations.
Tenofovir disoproxil fumarate (tenofovir DF) is an oral prodrug of tenofovir, a novel, acyclic nucleotide analogue with in vitro activity against HIV-1, HIV-2, and HBV.
Among patients who received tenofovir DF, 3 serious adverse effects that were not considered to be related to the study drug occurred (i.e., fever, schizophrenic reaction, and pneumonia), but none of these patients discontinued participation in the study as a result.
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