Hydrolysis of Taurocholic Acid yields Taurine, an amino acid. Taurine (from taurus = ox, as it was discovered in ox bile) or 2-aminoethanesulfonic acid is an acidic chemical substance found in bile which acts as an emulsifier for ingested lipids and assists in their absorption. ... In chemistry, an amino acid is any molecule that contains both amino and carboxylic acid functional groups. ...
The release of taurine, prompted by the excitatory amino acids, is a function of the movement of ions and water across cell membrane that is mitigated by the excitotoxins.
As with all cells, the release of amino acids in neurons of the brain is dependent on the presence of ions, which are responsible for opening and closing the membrane gates out of which the amino acid osmolytes flow.
Colorectal cancer patients exhibit a characteristic amino acid profile: significantly lower taurine, glutamine, valine, and tyrosine in plasma; significantly lower taurine, glutamic acid, methionine and ornithine intracellularly; and elevated valine, isoleucine, leucine, tyrosine, and phenylalanine intracellularly.
Taurocholic acid-induced secretion was monitored as a rise in short-circuit current (SCC) in ileal sheets from normal (Swiss MF1) and transgenic CF mice.
Taurocholicacid increased the SCC in both intact and stripped ileal sheets from Swiss MF1 mice.
Taurocholic acid-induced secretion was inhibited by tetrodotoxin, indicating the involvement of a neural pathway, but this did not include capsaicin-sensitive afferent neurons or muscarinic cholinoreceptors.
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