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Encyclopedia > Tablet
Common disk-shaped tablets
Common disk-shaped tablets

A tablet is a mixture of active substances and excipients, usually in powder form, pressed or compacted into a solid. The excipients include binders, glidants (flow aids) and lubricants to ensure efficient tabletting; disintegrants to ensure that the tablet breaks up in the digestive tract; sweetners or flavours to mask the taste of bad-tasting active ingredients; and pigments to make uncoated tablets visually attractive. A coating may be applied to hide the taste of the tablet's components, to make the tablet smoother and easier to swallow, and to make it more resistant to the environment, extending its shelf life. Download high resolution version (3072x2048, 761 KB)Flattened round pills This image has been released into the public domain by the copyright holder, its copyright has expired, or it is ineligible for copyright. ... Download high resolution version (3072x2048, 761 KB)Flattened round pills This image has been released into the public domain by the copyright holder, its copyright has expired, or it is ineligible for copyright. ... An excipient is an inactive substance used as a vehicle for medication, or an active ingredient. ... Powder is a substance that has been crushed into very fine grains. ...


Medicines to be taken orally are very often supplied in tablet form; indeed the word tablet without qualification would be taken to refer to a medicinal tablet. Medicinal tablets and capsules are often called pills. Other products are manufactured in the form of tablets which are designed to dissolve or disintegrate; e.g. cleaning and deodorizing products. This article does not cite any references or sources. ... In pharmacology, encapsulation refers to a range of techniques used to enclose medicines in a relatively stable shell, for example to allow them to be taken orally. ...


Medicinal tablets are usually intended to be swallowed, and are of a suitable size and shape. Tablets for other purposes, e.g., effervescent medicinal tablets and non-medicinal tablets, may be larger. Swallowing, known scientifically as deglutition, is the reflex in the human body that makes something pass from the mouth, to the pharynx, into the esophagus, with the shutting of the epiglottis. ... Carbonated bubbles in a soda float to the surface. ...


Medicinal tablets were originally made in the shape of a disk of whatever color their components determined, but are now made in many shapes and colors to help users to distinguish between different medicines that they take. Tablets are often stamped with symbols, letters, and numbers, which enable them to be identified. Sizes of tablets to be swallowed range from a few millimeters to about a centimeter. Some tablets are in the shape of capsules, and are called "caplets". In pharmacology, encapsulation refers to a range of techniques used to enclose medicines in a relatively stable shell, for example to allow them to be taken orally. ...


When Tylenol capsules were laced with cyanide (an incident referred to as the Tylenol scare), many people stopped buying capsules because they are easy to contaminate, in favor of tablets, which are not. Some makers of over-the-counter drugs responded by starting to make what they termed "caplets", which were actually just tablets made in the shape of a capsule. Each caplet in this bottle of Extra Strength Tylenol contains a 500 mg dose of acetaminophen (paracetamol). ... The cyanide ion, CN−. From the top: 1. ... The Tylenol murders occurred in the autumn of 1982, when seven people in the Chicago, Illinois area in the United States died after ingesting Extra Strength Tylenol medicine capsules which had been laced with cyanide poison. ...


Tablets are often scored to allow them to be easily broken into equal halves for smaller doses.


Some people have difficulty swallowing tablets, this is called dysphagia. This is often caused by a gag reflex. Dysphagia () is a medical term defined as difficulty swallowing. ... This article does not cite any references or sources. ...

Contents

Tabletting formulations

Capping (top) and lamination (right) tablet failure modes
Capping (top) and lamination (right) tablet failure modes

In the tablet-pressing process, it is important that all ingredients be fairly dry, powdered or granular, somewhat uniform in particle size, and freely flowing. Mixed particle sized powders can segregate due to operational vibrations, which can result in tablets with poor drug or active pharmaceutical ingredient (API) content uniformity. Content uniformity ensures that the same API dose is delivered with each tablet. Image File history File links Metadata Size of this preview: 800 × 501 pixelsFull resolution (1191 × 746 pixel, file size: 35 KB, MIME type: image/jpeg) Capping (top) and lamination (right) failure modes of tablets. ... Image File history File links Metadata Size of this preview: 800 × 501 pixelsFull resolution (1191 × 746 pixel, file size: 35 KB, MIME type: image/jpeg) Capping (top) and lamination (right) failure modes of tablets. ...


Some APIs may be tableted as pure substances, but this is rarely the case; most formulations include excipients. Normally, an inactive ingredient (excipient) termed a binder is added to help hold the tablet together and give it strength. A wide variety of binders may be used, some common ones including lactose powder, dibasic calcium phosphate, sucrose, corn (maize) starch, microcrystalline cellulose and modified cellulose (for example hydroxymethyl cellulose). An excipient is an inactive substance used as a vehicle for medication, or an active ingredient. ... Lactose is a disaccharide that consists of β-D-galactose and β-D-glucose molecules bonded through a β1-4 glycosidic linkage. ... Sucrose (common name: table sugar, also called saccharose) is a disaccharide (glucose + fructose) with the molecular formula C12H22O11. ... Cellulose as polymer of β-D-glucose Cellulose in 3D Cellulose (C6H10O5)n is a polysaccharide of beta-glucose. ...


Often, an ingredient is also needed to act as a disintegrant that hydrates readily in water to aid tablet dispersion once swallowed, releasing the API for absorption. Some binders, such as starch and cellulose, are also excellent disintegrants.


Small amounts of lubricants are usually added, as well. The most common of these is magnesium stearate; however, other commonly used tablet lubricants include stearic acid (stearin), hydrogenated oil, and sodium stearyl fumarate. These help the tablets, once pressed, to be more easily ejected from the die. Stearic acid, also called octadecanoic acid, is one of the useful types of saturated fatty acids that comes from many animal and vegetable fats and oils. ...


Tablet coating

Many tablets today are coated after being pressed. Although sugar-coating was popular in the past, the process has many drawbacks. Modern tablet coatings are polymer and polysaccharide based, with plasticizers and pigments included. Tablet coatings must be stable and strong enough to survive the handling of the tablet, must not make tablets stick together during the coating process, and must follow the fine contours of embossed characters or logos on tablets. Coatings can also facilitate printing on tablets, if required. Coatings are necessary for tablets that have an unpleasant taste, and a smoother finish makes large tablets easier to swallow. Tablet coatings are also useful to extend the shelf-life of components that are sensitive to moisture or oxidation. Opaque materials like titanium dioxide can protect light-sensitive actives from photodegradation. Special coatings (for example with pearlescent effects) can enhance brand recognition. A polymer (from Greek: πολυ, polu, many; and μέρος, meros, part) is a substance composed of molecules with large molecular mass composed of repeating structural units, or monomers, connected by covalent chemical bonds. ... Polysaccharides (sometimes called glycans) are relatively complex carbohydrates. ... Plasticizers are additives that soften the materials (usually a plastic or a concrete mix) they are added to. ... Natural Ultramarine pigment in powdered form. ... Titanium dioxide, also known as titanium(IV) oxide or titania, is the naturally occurring oxide of titanium, chemical formula TiO2. ... Photodegradation is degradation of a molecule caused by the absorption of photons, particularly those wavelengths found in sunlight, such as infrared radiation, visible light and ultraviolet light. ...


If the active ingredient of a tablet is sensitive to acid, or is irritant to the stomach lining, an enteric coating can be used, which is resistant to stomach acid and dissolves in the high pH of the intestines. Enteric coatings are also used for medicines that can be negatively affected by taking a long time to reach the small intestine where they are absorbed. Coatings are often chosen to control the rate of dissolution of the drug in the gastro-intestinal tract. Some drugs will be absorbed better at different points in the digestive system. If the highest percentage of absorption of a drug takes place in the stomach, a coating that dissolves quickly and easily in acid will be selected. If the rate of absorption is best in the large intestine or colon, then a coating that is acid resistant and dissolves slowly would be used to ensure it reached that point before dispersing. The area of the gastro-intestinal tract with the best absorption for any particular drug is usually determined by clinical trials. An enteric coating is a barrier applied to oral medication that controls the location in the digestive system where it is absorbed. ... In anatomy, the stomach is a bean-shaped hollow muscular organ of the gastrointestinal tract involved in the second phase of digestion, following mastication. ... In biology the small intestine is the part of the gastrointestinal tract (gut) between the stomach and the large intestine and includes the duodenum, jejunum, and ileum. ...


Tablet presses

An old Cadmach rotary tablet press
An old Cadmach rotary tablet press

Tablet presses, also called tabletting machines, range from small, inexpensive bench-top models that make one tablet at a time (single-station presses), no more than a few thousand an hour, and with only around a half-ton pressure, to large, computerized, industrial models (multi-station rotary or eccentric presses) that can make hundreds of thousands to millions of tablets an hour with much greater pressure. Some tablet presses can make extremely large tablets, such as some of the toilet cleaning and deodorizing products or dishwasher soap. Others can make smaller tablets, from regular aspirin to some the size of a bb gun pellet. Tablet presses may also be used to form tablets out of a wide variety of materials, from powdered metals to cookie crumbs. The tablet press is an essential piece of machinery for any pharmaceutical and nutraceutical manufacturer. Image File history File links Metadata Size of this preview: 297 × 599 pixelsFull resolution (1515 × 3057 pixel, file size: 319 KB, MIME type: image/jpeg) An old Cadmach rotary tablet press, photographed by David Richfield File historyClick on a date/time to view the file as it appeared at that... Image File history File links Metadata Size of this preview: 297 × 599 pixelsFull resolution (1515 × 3057 pixel, file size: 319 KB, MIME type: image/jpeg) An old Cadmach rotary tablet press, photographed by David Richfield File historyClick on a date/time to view the file as it appeared at that... For other uses, see Toilet (disambiguation). ... A Dishwasher A two drawer DishDrawer dishwasher. ... Aspirin, or acetylsalicylic acid (IPA: ), (acetosal) is a drug in the family of salicylates, often used as an analgesic (to relieve minor aches and pains), antipyretic (to reduce fever), and as an anti-inflammatory. ... Steel BBs BB guns are a type of air gun designed to fire spherical projectiles, called BBs, usually from a smoothbore barrel. ...


Pill-splitters

It is sometimes necessary to split tablets into halves or quarters. Tablets are easier to break accurately if scored, but there are devices called pill-splitters which cut unscored and scored tablets. Tablets with special coatings (for example enteric coatings or controlled-release coatings) should not be broken before use, as this will expose the tablet core to the digestive juices, short-circuiting the intended delayed-release effect. A pill-splitter is a simple and inexpensive device to split medicinal pills or tablets, comprising some means of holding the tablet in place, a blade, and usually a compartment in which to store the unused part. ...


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