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Encyclopedia > TNA (nucleic acid)

TNA is threose nucleic acid, a chemical similar to DNA or RNA but differing in the composition of its "backbone." TNA is not known to occur naturally in existing life on Earth. Fischer projection of D-threose D-Threose is a tetrose carbohydrate with the chemical formula C4H8O4. ... The general structure of a section of DNA Deoxyribonucleic acid (DNA) is a nucleic acid —usually in the form of a double helix— that contains the genetic instructions specifying the biological development of all cellular forms of life, and most viruses. ... Ribonucleic acid (RNA) is a nucleic acid polymer consisting of covalently bound nucleotides. ...

DNA and RNA have a deoxyribose and ribose sugar backbone, respectively, whereas TNA's backbone is composed of repeating threose units linked by peptide bonds. The threose molecule is easier to assemble than ribose making it a possible precursor to RNA. Deoxyribose Deoxyribose, also known as D-Deoxyribose and 2-deoxyribose, is an aldopentose — a monosaccharide containing five carbon atoms, and including an aldehyde functional group. ... Ribose Ribose is a five carbon sugar (pentose) that is critical to living creatures. ... A peptide bond is a chemical bond formed between two molecules when the carboxyl group of one molecule reacts with the amino group of the other molecule, releasing a molecule of water (H2O). ...

DNA TNA hybrid chains have been made in the laboratory using DNA polymerase.

External links

  • Was simple TNA the first nucleic acid on Earth to carry a genetic code? - New scientist
  • ORIGIN OF LIFE: A Simpler Nucleic Acid Leslie Orgel


  • Journal of the American Chemical Society, DOI: 10.1021/ja035917n
Nucleic acids edit
Nucleobases: Adenine - Thymine - Uracil - Guanine - Cytosine - Purine - Pyrimidine
Nucleosides: Adenosine - Uridine - Guanosine - Cytidine - Deoxyadenosine - Thymidine - Deoxyguanosine - Deoxycytidine
Nucleotides: AMP - UMP - GMP - CMP - ADP - UDP - GDP - CDP - ATP - UTP - GTP - CTP - cAMP - cGMP
Deoxynucleotides: dAMP - dTMP - dGMP - dCMP - dADP - dTDP - dGDP - dCDP - dATP - dTTP - dGTP - dCTP
Nucleic acids: DNA - mtDNA - cDNA - GNA - RNA - mRNA - tRNA - rRNA - ncRNA - siRNA - snRNA - miRNA - snoRNA - LNA - PNA - TNA - Oligonucleotide



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