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Encyclopedia > Sulfamethizole
Image:Sulfamethizole.png
Sulfamethizole
Systematic (IUPAC) name
4-amino-N- (5-methyl-1,3,4-thiadiazol-2-yl)- benzenesulfonamide
Identifiers
CAS number 144-82-1
ATC code B05CA04 D06BA04, J01EB02, S01AB01
PubChem 5328
DrugBank APRD00684
Chemical data
Formula C9H10N4O2S2
Mol. weight 270.333 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 98-99%
Metabolism  ?
Half life 3-8 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Many drugs are bound to Blood plasma proteins. ... Santorio Santorio (1561-1636) in his steelyard balance, from Ars de statica medecina, first published 1614 Metabolism (from μεταβολισμος (metabolismos)) is the biochemical modification of chemical compounds in living organisms anggjgjhnd cell (b). ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Sulfamethizole is a sulfonamide antibiotic. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... In chemistry, the sulfonamide functional group is -S(=O)2-NH2, a sulfone group connected to an amine group. ... An antibiotic is a drug that kills or slows the growth of bacteria. ...


External links

  • Ratanajamit C, Skriver M, Nørgaard M, Jepsen P, Schønheyder H, Sørensen H (2003). "Adverse pregnancy outcome in users of sulfamethizole during pregnancy: a population-based observational study.". J Antimicrob Chemother 52 (5): 837-41. PMID 14519675.
  • Kerrn M, Frimodt-Møller N, Espersen F (2003). "Effects of sulfamethizole and amdinocillin against Escherichia coli strains (with various susceptibilities) in an ascending urinary tract infection mouse model.". Antimicrob Agents Chemother 47 (3): 1002-9. PMID 12604534.
  • Watanabe H, Hastings J (1990). "Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine.". Biochim Biophys Acta 1017 (3): 229-34. PMID 2372557.


Sulfonamides (J01E) edit

Mafenide, Prontosil, Sulfacetamide, Sulfamethizole, Sulfamethoxazole (with Trimethoprim in Co-trimoxazole), Sulfanilimide, Sulfasalazine, Sulfisoxazole There are several sulphonamide-based groups of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... Mafenide is a sulfonamide often used to treat severe burns. ... Prontosil is the first successful oral antibiotic developed by Gerhard Domagk, who received the 1939 Nobel Prize in Medicine. ... Sulfacetamide is a sulfonamide antibiotic. ... Sulfamethoxazole is a sulfonamide antibiotic. ... Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections (cystitis). ... Co-trimoxazole (abbreviated SXT) is a bacteriostatic antibiotic combination of trimethoprim and sulfamethoxazole, in the ratio of 1 to 5, used in the treatment of a variety of bacterial infections. ... Sulfonamides, also known as sulfa drugs, are synthetic antimicrobial agents derived from sulfonic acid. ... Sulfasalazine is a sulfa drug, a derivative of Mesalazine (5-aminosalicylic acid abbreviated as 5-ASA), used primarily as an anti-inflammatory agent in the treatment of inflammatory bowel disease as well as for rheumatoid arthritis. ...


  Results from FactBites:
 
MEDLINE Search on Medscape.com (295 words)
Effects of sulfamethizole and amdinocillin against Escherichia coli strains (with various susceptibilities) in an ascending urinary tract infection mouse model.
The aim of this study was to increase the solubility of sulfamethizole in water by complexing it with beta-cyclodextrin (BCD) and...
Sulfamethizole capsules containing contrast medium for assessment of gastric emptying in functional dyspepsia patients.
Sulfonamides General Statement (8:12.20) - 382915 (5842 words)
Combination preparations containing sulfamethizole or sulfisoxazole with phenazopyridine hydrochloride are commercially available and may be used for the initial treatment of uncomplicated urinary tract infections caused by susceptible organisms when relief of symptoms of pain, burning, or urgency is needed during the first 2 days of therapy.
Sulfamethizole reportedly may inhibit metabolism of phenytoin and should be used with caution in patients receiving the drug.
Sulfamethizole, sulfasalazine, and sulfisoxazole are generally considered to be short-acting sulfonamides and reportedly have plasma half-lives of about 4–8 hours.
  More results at FactBites »

 
 

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