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Encyclopedia > Sulbutiamine
Sulbutiamine chemical structure
Systematic (IUPAC) name
yl]disulfanyl-pent-3-enyl] 2-methylpropanoate
CAS number 3286-46-2
ATC code A11DA02
PubChem 71124
Chemical data
Formula C32H46N8O6S2
Mol. weight 702.89 g/mol
Synonyms Arcalion, bisibuthiamine, youvitan
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 5 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

? IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A division of the Anatomical Therapeutic Chemical Classification System A Alimentary tract and metabolism // A11A Multivitamins, combinations A11AA Multivitamins with minerals A11AA01 Multivitamins and iron A11AA02 Multivitamins and calcium A11AA03 Multivitamins and other minerals, including combinations A11AA04 Multivitamins and trace elements A11AB Multivitamins, other combinations A11B Multivitamins, plain A11BA Multivitamins... PubChem is a database of chemical molecules . ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... The simplified molecular input line entry specification or SMILES is a specification for unambiguously describing the structure of chemical molecules using short ASCII strings. ... Synonyms (in ancient Greek syn συν = plus and onoma όνομα = name) are different words with similar or identical meanings. ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Santorio Santorio (1561-1636) in his steelyard balance, from Ars de statica medecina, first published 1614 Metabolism (from μεταβολισμος (metabolismos)) is the biochemical modification of chemical compounds in living organisms anggjgjhnd cell (b). ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... Human kidneys viewed from behind with spine removed The kidneys are bean-shaped excretory organs in vertebrates. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes Oral

Sulbutiamine (brand name: Arcalion®) is a precursor to thiamine (i.e., vitamin B1). It is indicated for the treatment of asthenia[1]. Furthermore, the ability of sulbutiamine to reduce fatigue is considered desirable by athletes, and a patented combination of it and caffeine called Spike® is available for over-the-counter sale as a nutritional supplement. Additionally, the demonstrated ability of sulbutiamine to improve memory in rats[2] and patients of schizophrenia[2] suggests that it is a nootropic. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... A precursor is something that existed before and was incorporated into something that came later. ... Thiamine mononitrate Thiamine or thiamin, also known as vitamin B1, is a colorless compound with chemical formula C12H17N4OS. It is soluble in water and insoluble in alcohol. ... Retinol (Vitamin A) Vitamins are nutrients required for essential metabolic reactions in the body [1]. Vitamins can act both as catalysts and participants in chemical reactions. ... Asthenia is a medical term denoting weakness, lack of energy and strength. ... For other uses, see Caffeine (disambiguation). ... Over-the-counter drugs are medicines that may be sold without a prescription and without a visit to a medical professional, in contrast to prescription only medicines (POM). ... Nootropics are so-called smart drugs. ...



Sulbutiamine reduces fatigue, memory difficulties, intellectual tiredness and may speed convalescence.[3]


Sulbutiamine is supplied in 200 mg tablets. The proper therapeutic dosage has been reported to be 12.5 mg/kg[2], which corresponds to 850 mg for a 68 kg (150 lb) person. However, it should be noted that dosage recommendations vary; the manufacturer of Arcalion, for example, recommends no more than 600 mg per day.


  1. ^ Shah SN; Sulbutiamine Study Group (2003). "Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia.". J Assoc Physicians India 51: 891–5. PMID 14710977.
  2. ^ a b c Bizot JC, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H (2005). "Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task.". Prog Neuropsychopharmacol Biol Psychiatry 29 (6): 928–35. PMID 15951087.
  3. ^ http://www.serdiapharma.com/about/arcalion.asp

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