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Encyclopedia > Succinate dehydrogenase

Succinate - coenzyme Q reductase also called succinate dehydrogenase is an enzyme complex found in the matrix part of the inner mitochondrial membrane. The enzyme complex has two main parts where one is part of both the citric acid cycle with the task of converting succinate into fumarate and the other is complex II of the electron transport chain, which uses electrons freed from succinate, to reduce ubiquinone to ubiquinol, ubiquinol is the input of the next complex in the electron transport chain, complex III, coenzyme Q - cytochrome c reductase.

In the citric acid cycle succinate is oxidized by the succinate dehydrogenase part of the complex and 2e- + 2H+ is transferred from succinate to FAD, a coenzyme which is covalently attached to a histidine residue in the enzyme. FADH2, the reduced form of FAD, will then transfer the two electrons to iron-sulfur clusters inside the enzyme and release the 2H+ back into the micochondrial matrix. The iron-sulfur clusters will reduce ubiquinone, Q, to ubiquinol, QH2.

  Results from FactBites:
SARDH - sarcosine dehydrogenase (4405 words)
Succinate dehydrogenase (SDH) activity in liver was measured to evaluate the effect of Jat on aerobic glycolysis in liver.
Succinate dehydrogenase (SDH); mitochondrial complex II) germline mutations cause CB paragangliomas and there is evidence that the severity and the population genetics of paragangliomas may be influenced by altitude.
Inherited defects of the mitochondrial succinate dehydrogenase (SDH) in humans are associated with striking variable clinical presentations ranging from early-onset devastating encephalomyopathy to tumour susceptibility in adulthood, or optic atrophy in the elderly.
Enzyme kinetics (338 words)
Succinate dehydrogenase is one of the nine enzymes that carry out the tricarboxylic acid cycle, and is the only one of the nine to be embedded in the inner membrane of the mitochondrion.
Succinate dehydrogenase catalyzes the conversion of succinate to fumarate with the concomitant reduction of FAD to FADH
We will isolate preparations of the enzyme succinate dehydrogenase from the mitochondria of cauliflower and measure the activity of this enzyme using a spectrophotometric based assay.
  More results at FactBites »



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