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Encyclopedia > Streptokinase
Systematic (IUPAC) name
Streptococci streptokinase
CAS number 9002-01-1
ATC code B01AD01 B06AA55
PubChem  ?
DrugBank BTD00028
Chemical data
Formula C2100H3278N566O669S4
Mol. weight 47286.7 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Metabolism (from Greek μεταβολισμός metabolismos) is the biochemical modification of chemical compounds in living organisms and cells. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Streptokinase is an extracellular metallo-enzyme produced by beta-haemolytic streptococcus and is used as an effective and cheap clot-dissolving medication in some cases of myocardial infarction (heart attack) and pulmonary embolism. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Ribbon diagram of the enzyme TIM, surrounded by the space-filling model of the protein. ... Streptococcus, a genus of spherical, Gram-positive bacteria of the phylum Firmicutes. ... Coagulation is the thickening or congealing of any liquid into solid clots. ... Oral medication A medication is a licenced drug taken to cure or reduce symptoms of an illness or medical condition. ... A myocardial infarction occurs when an atherosclerotic plaque slowly builds up in the inner lining of a coronary artery and then suddenly ruptures, totally occluding the artery and preventing blood flow downstream. ...

It belongs to a group of medications known as fibrinolytics, and works by activating plasminogen through cleavage to produce plasmin. The half life of streptokinase is six hours. Thrombolytic drugs are used in medicine to dissolve blood clots in a procedure termed thrombolysis. ... Plasmin is an important degrading enzyme (EC 3. ... Plasmin is an important degrading enzyme (EC 3. ...

Plasmin is produced in the blood to break down the major constituent of blood clots fibrin, therefore dissolving clots once they have fulfilled their purpose in stopping bleeding. Extra production of plasmin caused by streptokinase breaks down unwanted blood clots, for example, in the lungs (pulmonary embolism). Human blood smear: a - erythrocytes; b - neutrophil; c - eosinophil; d - lymphocyte. ... Fibrin is a protein involved in the clotting of blood. ... The heart and lungs (from an older edition of Grays Anatomy) The lung is an organ belonging to the respiratory system and interfacing to the circulatory system of air-breathing vertebrates. ...

It is given intravenously as soon as possible after the onset of a heart attack (acute phase - myocardial infarction) to dissolve clots in the arteries of the heart wall. This reduces the amount of damage to the heart muscle. Streptokinase is a bacterial product so the body will build up an immunity to it. It is recommended that this medication should not be used again after four days from the first administration, as it may not be as effective and can also cause an allergic reaction. For this reason, it is usually given only for a person's first heart attack. An intravenous drip in a hospital Intravenous therapy or IV therapy is the administration of liquid substances directly into a vein. ... Section of an artery An artery or arterial is also a class of highway. ... Phyla/Divisions Actinobacteria Aquificae Bacteroidetes/Chlorobi Chlamydiae/Verrucomicrobia Chloroflexi Chrysiogenetes Cyanobacteria Deferribacteres Deinococcus-Thermus Dictyoglomi Fibrobacteres/Acidobacteria Firmicutes Fusobacteria Gemmatimonadetes Nitrospirae Omnibacteria Planctomycetes Proteobacteria Spirochaetes Thermodesulfobacteria Thermomicrobia Thermotogae Bacteria (singular, bacterium) are a major group of living organisms. ... Pancreatitus can be caused by an Allergic Reaction to a food. ...

Antithrombotics (thrombolytics, anticoagulants, and antiplatelet drugs) (B01) edit
Vitamin K antagonists:

Acenocoumarol, Clorindione, Dicumarol (Dicoumarol}, Diphenadione, Ethyl biscoumacetate, Phenprocoumon, Phenindione, Tioclomarol, Warfarin Thrombolytic drugs are used in medicine to dissolve blood clots in a procedure termed thrombolysis. ... An anticoagulant is a substance that prevents coagulation; that is, it stops blood from clotting. ... An antiplatelet drug is a member of a class of pharmaceuticals that decreases platelet aggregation and inhibits thrombus formation. ... A section of the Anatomical Therapeutic Chemical Classification System. ... Acenocoumarol is a anticoagulant that functions as a vitamin K antagonist (like warfarin). ... Dicumarol (or Dicoumarol) is a anticoagulant that functions by as a Vitamin K antagonist (similar to warfarin). ... Phenprocoumon is a anticoagulant, functioning as a Vitamin K antagonist. ... Phenindione is an anticoagulant which functions as a Vitamin K antagonist. ... Warfarin (also known under the brand names of Coumadin®, Jantoven®, Marevan®, and Waran®) is an anticoagulant medication that is administered orally or, very rarely, by injection. ...

Heparin group (Platelet
aggregation inhibitors):

Antithrombin III, Bemiparin, Dalteparin, Danaparoid, Enoxaparin, Heparin, Nadroparin, Parnaparin, Reviparin, Sulodexide, Tinzaparin Antithrombin is a small molecule that inactivates several enzymes of the coagulation system. ... Dalteparin is a low molecular weight heparin. ... Danaparoid sodium (Orgaran®) is an anticoagulant that works by inhibiting thrombin. ... Enoxaparin is a low molecular weight heparin manufactured by Sanofi-Aventis. ... Heparin is a highly sulfated glycosaminoglycan widely used as an injectable anticoagulant. ... In medicine, low molecular weight heparin (LMWH) is a class of medication used as an anticoagulant in diseases that feature thrombosis, as well as for prophylaxis in situations that lead to a high risk of thrombosis. ...

Other Platelet
aggregation inhibitors:

Abciximab, Acetylsalicylic acid (Aspirin), Aloxiprin, Beraprost, Ditazole, Carbasalate calcium, Cloricromen, Clopidogrel, Dipyridamole, Epoprostenol, Eptifibatide, Indobufen, Iloprost, Picotamide, Prasugrel, Ticlopidine, Tirofiban, Treprostinil, Triflusal Abciximab (previously known as c7E3 Fab), distributed by Eli Lilly under the trade name ReoPro®, is a platelet aggregation inhibitor mainly used during and after coronary artery procedures like angioplasty to prevent platelets from sticking together and causing thrombus (blood clot) formation within the coronary artery. ... A very old bottle of Aspirin Aspirin or acetylsalicylic acid is a drug in the family of salicylates, often used as an analgesic (against minor pains and aches), antipyretic (against fever), and anti-inflammatory. ... Beraprost is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary hypertension. ... Clopidogrel (IPA: ) is a potent oral antiplatelet agent often used in the treatment of coronary artery disease, peripheral vascular disease, and cerebrovascular disease. ... Dipyridamole is a drug that inhibits platelet aggregation and causes vasodilation. ... Prostacyclin is a member of the family of lipid molecules known as eicosanoids. ... Eptifibatide (Integrilin®, Millennium Pharmaceuticals) is a anti-coagulant that selectively blocks the platelet glycoprotein IIb/IIIa receptor. ... iloprost, an inhalation solution, is sold under the name Ventavis® and is used to treat pulmonary arterial hypertension (PAH). ... Prasugrel is a novel platelet inhibitor developed by Sankyo and produced by Ube and currently under clinical development in cooperation with Eli Lilly for acute coronary syndromes planned for PCI. Categories: Biochemistry stubs | Pharmacology stubs ... Ticlopidine is a drug used for its antiplatelet action. ... Tirofiban (INN, trade name Aggrastat®) is an anticoagulant drug. ... Trepostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension. ...


Alteplase, Ancrod, Anistreplase, Brinase, Drotrecogin alfa, Fibrinolysin, Protein C, Reteplase, Saruplase, Streptokinase, Tenecteplase, Urokinase In blood coagulation, tissue plasminogen activator (tPA) is an enzyme (EC 3. ... // Basic Chemical, Pharmacological, and Marketing Information Ancrod (also known under its former brand name Arwin® and recently Viprinex®) is an anticoagulant with a triple mode of action. ... Anistreplase is a thrombolytic drug. ... // Basic Chemical, Pharmacological and Marketing Data Drotrecogin alpha (activated) is a recombinant form of human activated protein C that has antithrombotic, antiinflammatory, and profibrinolytic properties. ... // Basic Information Fibrinolysin is an enzyme derived from plasma of bovine origin or extracted from cultures of certain bacteria. ... Protein C is a major physiological anticoagulant. ... Reteplase (Retavase®) is a thrombolytic drug, used to treat heart attacks by breaking up the clots that cause them. ... Tenecteplase is an enzyme used as a thrombolytic drug. ... Urokinase, also called urokinase-type Plasminogen Activator (uPA) is an enzyme (EC 3. ...

Direct thrombin inhibitors:

Argatroban, Bivalirudin, Dabigatran, Desirudin, Hirudin, Lepirudin, Melagatran, Ximelagatran Direct thrombin inhibitors (DTIs) are a class of medication that act as anticoagulants (delaying blood clotting) by directly inhibiting the enzyme thrombin. ... Argatroban is a small molecule direct thrombin inhibitor. ... Basic Chemical and Pharmacological Properties Bivalirudin is an anticoagulant and acts as direct thrombin antagonist. ... Dabigatran is an anticoagulant from the class of the direct thrombin inhibitors. ... Hirudin is a naturally ocurring peptide in the salivary glands of medicinal leeches (Hirudo medicinalis) that has a blood anticoagulant property. ... Lepirudin is an anticoagulant which functions as a direct thrombin inhibitor. ... Ximelagatran (Exanta®, H 376/95) is an anticoagulant that has been investigated extensively but is awaiting approval by the Food and Drug Administration (FDA). ... Ximelagatran (Exanta®, H 376/95) is an anticoagulant that has been investigated extensively but is awaiting approval by the Food and Drug Administration (FDA). ...

Other antithrombotics:

Dabigatran, Defibrotide, Dermatan sulfate, Fondaparinux, Rivaroxaban Dabigatran is an anticoagulant from the class of the direct thrombin inhibitors. ... // Basic Data Defibrotide is a deoxyribonucleic acid derivative (single stranded) derived from cow lung or porcine mucosa. ... Dermatan sulfate is a glycosaminoglycan, formerly called a mucopolysaccharide, found mostly in skin, but also in blood vessels, heart valves, tendons, and lungs. ... Fondaparinux (Arixtra) is a medication that is an anticoagulant. ... Rivaroxaban (also known as BAY 59-7939) is an oral anticoagulant under development by Bayer. ...


Citrate, EDTA, Oxalate An anticoagulant is a substance that prevents coagulation; that is, it stops blood from clotting. ... Chemical strucutre of citric acid. ... EDTA is the chemical compound ethylenediaminetetraacetic acid. ... An oxalate (called also: ethanedioate) is a salt or ester of oxalic acid. ...

  Results from FactBites:
In this case streptokinase was acting as the inhibitor of fibrinolysis.
For the sake of prevention, the wife was indicated antichlamydial enzyme therapy course with streptokinase.
Inhibition of fibrinolysis and the secondary-induced hypercoagulaemia are not dependant on the pharmacokinetic properties of streptokinase but depend on the disease, the inflammation process and the degradation level of the fibrinogen molecule.
EBM Syllabi - EBM in Developing Countries - MI-streptokinase (345 words)
'streptokinase' [MESH] and 'myocardial infarction' [MESH] and 'mortality' [MESH] from Cochrane Library
From the whole process, you were able to determine the importance of the evidence and more significantly, appreciate its application in clinical practice.
The data you gathered can now be used in convincing the hospital board on the effectiveness of streptokinase in decreasing in-hospital mortality.
  More results at FactBites »



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