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Encyclopedia > Sphingosine

Sphingosine is a compound that forms a primary part of the sphingolipids, a class of cell membrane lipids which includes sphingomyelin, an important phospholipid. Sphingosine can be phosphorylated in vivo via two kinases, sphingosine kinase type 1 and sphingosine kinase type 2. Image:Sphingosine.png A member of a class of lipids derived from the aliphatic amino alcohol sphingosine. ... Drawing of a cell membrane A component of every biological cell, the selectively permeable cell membrane (or plasma membrane or plasmalemma) is a thin and structured bilayer of phospholipid and protein molecules that envelopes the cell. ... Figure 1: Structure of a Lipid. ... Sphingomyelin is a type of lipid involved in the nervous system of animals, used to increase the speed of transmission. ... Two schematic representations of a phospholipid. ... Phosphorylation is the addition of a phosphate (PO4) group to a protein or a small molecule. ... In biochemistry, a kinase is a type of enzyme that transfers phosphate groups from, for example, ATP to a specified substrate or target; the process is termed phosphorylation. Typically, the target is activated or energized by being phosphorylated. ... Image File history File links Structural formula of sphingosine File history Legend: (cur) = this is the current file, (del) = delete this old version, (rev) = revert to this old version. ...


Synthesis

Sphingosine is synthesized from palmitoyl CoA and serine in a condensation requires to yield dehydrosphingosine. Dehydrosphingosine is then reduced by NADPH to dihydrosphingosine, and finally oxidized by FAD to sphingosine. Palmitate, also called n-hexadecanoate, is the dissociated and observed form of Palmitic Acid at physiological pH. Palmitate is a saturated 16 carbon fatty acid, and the first product of lipogenesis aka Fatty Acid Synthesis. ... Categories: Biochemistry stubs | Thiols ... Serine is one of the 20 most common natural amino acids on Earth. ...


Image:Sphingosine-Synthesis.png Image File history File links Reactions in synthesis of sphingosine File history Legend: (cur) = this is the current file, (del) = delete this old version, (rev) = revert to this old version. ...


 
 

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