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Encyclopedia > Small hairpin RNA

A short hairpin RNA (shRNA) is a sequence of RNA that makes a tight hairpin turn that can be used in gene expression silence. Ribonucleic acid (RNA) is a nucleic acid polymer consisting of covalently bound nucleotides. ... A nearly 180-degree turn in a road, trail, or ramp is called a hairpin turn (also hairpin bend or, if in a trail, a switchback). ... This stylistic schematic diagram shows a gene in relation to the double helix structure of DNA and to a chromosome (right). ...


Bibliography

  • Design and cloning strategies for constructing shRNA expression vectors
  • RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model.
  • Molecular strategies to inhibit HIV-1 replication
  • Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

 
 

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