5-HT2 receptors are Gq/G11 coupled, mediating cellular effects through increasing cellular levels of inositol trisphosphate (IP3) and diacylglycerol (DAG). Three subtypes exist, namely 5-HT2A, 5-HT2B, and 5-HT2C (formerly called 5-HT1C).
Note that there is no 5-HT1C receptor since, after the receptor was cloned and further characterised, it was found to have more in common with the 5-HT2 family of receptors and was redesignated as the 5-HT2C receptor.
In the field of neurochemistry, 5-HT receptors are receptors for the neurotransmitter and peripheral signal mediator serotonin, also known as 5-hydroxytryptamine or 5-HT.
5-HT receptors are located on the cell membrane of nerve cells and other cell types in animals and mediate the effects of serotonin as the endogenous ligand and of a broad range of pharmaceutical and hallucinogenic drugs.
With the exception of the 5-HT receptor, a ligand gated ion channel, all other 5-HT receptors are G protein coupled seven transmembrane (or heptahelical) receptors that activate an intracellular second messenger cascade.
Serotoninreceptors are also thought to be linked to the direct modification of ion channel states, and are implicated in mechanisms associated with pain, migraine headaches, and motor control.
The serotoninreceptor is shown to belong to the family of rhodopsin-like signal transducers which are distinguished by their seven-transmembrane configuration and their functional linkage to G-proteins.
Receptor RNA was not detected in the cerebellum or in liver, kidney, intestine, heart, and lung.
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