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Encyclopedia > Saquinavir
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Saquinavir (Fortovase®, Roche) is a protease inhibitor, used as a component of HIV therapy. Roche is French for boulder. The word is (part of) several names: // Places in France Roche, in the Isère département Roche, in the Loire département Roche-Charles-la-Mayrand, in the Puy-de-Dôme département Roche-dAgoux, in the Puy-de-Dôme d... Protease inhibitor can refer to: Protease inhibitor (pharmacology): a class of medication that inhibits viral protease Protease inhibitor (biology): a group of proteins that inhibit proteases. ... Jump to: navigation, search The human immunodeficiency virus, commonly called HIV, is a retrovirus that primarily infects vital components of the human immune system such as CD4+ T cells, macrophages and dendritic cells. ... The term antiretroviral drugs is used to describe drugs used against HIV infection (HIV is an RNA retrovirus). ...


Saquinavir mesylate (Invirase®, Roche) is a different formulation, designed to be combined with another protease inhibitor that increases the bioavailability of the saquinavir. Roche is French for boulder. The word is (part of) several names: // Places in France Roche, in the Isère département Roche, in the Loire département Roche-Charles-la-Mayrand, in the Puy-de-Dôme département Roche-dAgoux, in the Puy-de-Dôme d... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ...


When given alone the HIV Protease Inhibitor (HPI) saquinavir has a very low oral bioavailability. In the clinic it was found that when patients also received the HPI ritonavir the oral bioavailability of saquinavir significantly increases. For patients this has the major benefit that they can take less saquinavir, while maintaining sufficient saquinavir blood plasma levels to efficiently suppress the replication of HIV. The mechanism behind this welcome observation was not directly known, but later it was determined that ritonavir inhibits the enzym Cytochrome P450 3A4. Normally, this enzym metabolized saquinavir to an inactive form and with the ritonavir inhibiting this enzym the saquinavir blood plasma levels increased considerably. Additionally, ritonavir also inhibits multidrug transporters, although to a much lower extent. Ritonavir is a drug from the protease inhibitor class used to treat AIDS. It is manufactured as Norvir® by Abbott Laboratories. ...


Antivirals edit
Antiherpesvirus agents edit

{Acyclovir} {Cidofovir} {Docosanol} {Famciclovir} {Foscarnet} {Fomivirsen} {Ganciclovir} {Idoxuridine} {Penciclovir} {Trifluridine} {Valaciclovir} {Valganciclovir} {Vidarabine} Wikipedia does not yet have an article with this exact name. ... Aciclovir (INN) or aciclovir (USAN), marketed as Zovirax®, is one of the main antiviral drugs. ... Jump to: navigation, search Chemical structure of cidofovir Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA synthesis. ... Jump to: navigation, search Docosanol 10% cream is a topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters). ... Ganciclovir sodium (Cytovene®) is an antiviral medication used to treat cytomegalovirus (CMV) infections. ... Jump to: navigation, search Valaciclovir (INN) or valacyclovir (USAN) is an antiviral drug used in the management of herpes simplex. ... Jump to: navigation, search Valganciclovir hydrochloride (Valcyte®) is an antiviral medication used to treat cytomegalovirus infections. ... Jump to: navigation, search Chemical structure of vidarabine Vidarabine is an anti-viral drug which is active against herpes simplex and varicella zoster viruses. ...

Antiinfluenza agents [ ]

{Amantadine} {Oseltamivir} {Rimantidine} {Zanamivir} Jump to: navigation, search Antiviral drugs are a class of medication used specifically for treating viral infections. ... Jump to: navigation, search Amantadine, 1-aminoadamantane, is an antiviral drug that was approved by the FDA in 1976 for the treatment of influenza type A in adults. ... Jump to: navigation, search Oseltamivir is an antiviral drug, a neuraminidase inhibitor used in the treatment and prophylaxis of both influenza A and influenza B. Oseltamivir was the first orally active neuraminidase inhibitor commercially developed. ... Jump to: navigation, search Zanamivir is a neuraminidase inhibitor used in the treatment of and prophylaxis of both influenza A and influenza B. Zanamivir was the first neuraminidase inhibitor commercially developed. ...


Antiretrovirals edit

NRTIs edit Jump to: navigation, search Antiretroviral drugs are medications for the treatment of infection by the retrovirus HIV. Different antiretroviral drugs act at various stages of the HIV life cycle. ... Jump to: navigation, search Antiretroviral drugs are medications for the treatment of infection by the retrovirus HIV. Different antiretroviral drugs act at various stages of the HIV life cycle. ...

{Zidovudine} {Didanosine} {Stavudine} {Zalcitabine} {Lamivudine} {Abacavir} Jump to: navigation, search Zidovudine (INN) or azidothymidine (abbreviated to AZT) is an antiretroviral drug, the first antiviral treatment to be approved for use against HIV. It is also sold under the names Retrovir and Retrovis, and as an ingredient in Combivir and Trizivir. ... Jump to: navigation, search Didanosine (2-3-dideoxyinosine, ddI, Videx®) differs from other nucleoside analogues, because it does not have any of the regular bases, instead it has hypoxanthine attached to the sugar ring. ... Jump to: navigation, search Stavudine (2-3-didehydro-2-3-dideoxythymidine, d4T, brand name Zerit®) is a thymidine analogue active against HIV. It is phosphorylated by cellular kinases into active triphosphate. ... Jump to: navigation, search Zalcitabine (2-3-dideoxycytidine, ddC), is a derivative of the naturally existing deoxycytidine, made by replacing the hydroxyl group in position 3 with a hydrogen. ... Lamivudine(2-3-dideoxy-3-thiacytidine, 3TC) is a potent reverse transcriptase inhibitor. ... Jump to: navigation, search Abacavir (ABC) is extremely potent reverse transcriptase inhibitor, meant for the treatment of AIDS. ABC is capable of crossing the blood-brain barrier. ...


NNRTIs edit Jump to: navigation, search Antiretroviral drugs are medications for the treatment of infection by the retrovirus HIV. Different antiretroviral drugs act at various stages of the HIV life cycle. ...

{Nevirapine} {Efavirenz} {Delavirdine} Jump to: navigation, search Nevirapine is a controversial AIDS drug. ... Jump to: navigation, search This article needs to be cleaned up to conform to a higher standard of quality. ...


PIs edit Jump to: navigation, search Antiretroviral drugs are medications for the treatment of infection by the retrovirus HIV. Different antiretroviral drugs act at various stages of the HIV life cycle. ...

{Saquinavir} {Indinavir} {Atazanavir} {Ritonavir} {Nelfinavir} {Amprenavir} {Lopinavir} Categories: Stub ... Ritonavir is a drug from the protease inhibitor class used to treat AIDS. It is manufactured as Norvir® by Abbott Laboratories. ... Jump to: navigation, search Nelfinavir (Viracept®) is an antitretroviral drug used in the treatment of the human immunodeficiency virus (HIV). ...


Other antiviral agents edit

{Fomivirsen} {Imiquimod} {Interferon} {Lamivudine} {Ribavirin} Jump to: navigation, search Antiviral drugs are a class of medication used specifically for treating viral infections. ... Jump to: navigation, search Interferons (IFNs) are natural proteins produced by the cells of the immune systems of most animals in response to challenges by foreign agents such as viruses, bacteria, parasites and tumor cells. ... Lamivudine(2-3-dideoxy-3-thiacytidine, 3TC) is a potent reverse transcriptase inhibitor. ... Ribavirin (Copegus®; Rebetol®) is an anti-viral drug active against a number of DNA and RNA viruses. ...


  Results from FactBites:
 
Invirase Online, Description, Chemistry, Ingredients - Saquinavir Mesylate - RxList Monographs (881 words)
Saquinavir is a peptide-like substrate analogue that binds to the protease active site and inhibits the activity of the enzyme.
In vitro antiviral activity of saquinavir was assessed in lymphoblastoid and monocytic cell lines and in peripheral blood lymphocytes.
Saquinavir in combination with the protease inhibitors amprenavir, atazanavir, or lopinavir resulted in synergistic antiviral activity.
Aidsmap | Saquinavir - overview (2815 words)
Saquinavir is cleared from the body more slowly by women than men, so the drug reaches higher levels in the blood and brings about better virological responses in women (Fletcher 2004).
Saquinavir was the first PI to be commonly combined with low-dose ritonavir to boost drug concentrations and simplify dosing.
Soft gel saquinavir must be stored in a refrigerator, but as long as capsules are not exposed to high temperatures, individual doses can be carried in a pillbox or other container during the daytime for the sake of convenience.
  More results at FactBites »

 
 

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