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Encyclopedia > Roche Holding AG
F. Hoffmann-La Roche, Ltd.
Image:Logo roche.gif
Type Public (parent company Roche Holding AG traded under RHHBY.PK)
Founded 1896
Headquarters Basel, Switzerland, US headquarters in Nutley, New Jersey
Key people Franz B. Humer (CEO)
William M. Burns (CEO of pharmaceuticals division)
Severin Schwan (CEO of diagnostics division)
Jonathan Knowles (Director of Research)
Industry Pharmaceutical
Revenue > $US 30 billion annually (1993, 1994)
Website http://www.roche.com/

Hoffmann-La Roche, Ltd. is a Swiss global health-care company which operates world-wide under two divisions: pharmaceuticals and diagnostics. It belongs to the Roche Holding AG. The headquarters are located in Basel and the company has additional sites in Welwyn Garden City in the United Kingdom, Nutley, Palo Alto, and Florence in the United States, Penzberg, Germany, and Shanghai, China. The company also owns a majority of the American biotechnology company Genentech and the Japanese biotechnology company Chugai Pharmaceuticals. Image File history File links Logo for F. Hoffman-La Roche, Ltd. ... 1896 (MDCCCXCVI) was a leap year starting on Wednesday (see link for calendar). ... Basel (English traditionally: Basle [ba:l], German: Basel [ba:[email protected]], French Bâle [ba:l], Italian Basilea [bazilE:a]) is Switzerlands third most populous city (188,000 inhabitants in the canton of Basel-City as of 2004; the 690,000 inhabitants in the conurbation stretching across the... Map of Nutley Township in Essex County Nutley is a Walsh Act town located in Essex County, New Jersey. ... Chief Executive Officer (CEO) is the job of having the ultimate executive responsibility or authority within an organization or corporation. ... Chief Executive Officer (CEO) is the job of having the ultimate executive responsibility or authority within an organization or corporation. ... Chief Executive Officer (CEO) is the job of having the ultimate executive responsibility or authority within an organization or corporation. ... A pharmaceutical company, or drug company, is a company licensed to discover, develop, market and distribute drugs. ... To meet Wikipedias quality standards, this article or section may require cleanup. ... Website - Wikipedia, the free encyclopedia /**/ @import /skins-1. ... A pharmaceutical company, or drug company, is a company licensed to discover, develop, market and distribute drugs. ... Diagnosis (from the Greek words dia = by and gnosis = knowledge) is the process of identifying a disease by its signs, symptoms and results of various diagnostic procedures. ... Basel (British English traditionally: Basle and more recently Basel , German: Basel , French: Bâle , Italian, Spanish: Basilea and Czech: Basilej ) is Switzerlands third most populous city (166,563 inhabitants (2004); 690,000 inhabitants in the conurbation stretching across the immediate cantonal and national boundaries made Basel Switzerlands second... Welwyn Garden City is a town (not a city) in Hertfordshire, England. ... Nutley is a Walsh Act town located in Essex County, New Jersey. ... Downtown Palo Alto Palo Alto is a city in Santa Clara County, in the San Francisco Bay Area of California, USA. Palo Alto is located at the northern end of the Silicon Valley, and is home to Stanford University (which is technically located in an adjacent area — Stanford, California... Penzberg is a town in Germany, located near Munich. ... Shanghai (Chinese: ; pinyin: ; Shanghainese: ), stuated on the banks of the Yangtze River Delta in East China, is the largest city of the Peoples Republic of China. ... Genentech, Inc. ...


Roche Holding AG (ticker ROC.S) is listed on the London-based virt-x stock exchange (virt-x is a company of the SWX Swiss Exchange). Roche's revenues during fiscal year 2005 were $26984 million. Descendants of the founding Hoffmann and Oeri families own half of the company. Fellow Swiss pharmaceutical giant Novartis owns 33% of the company (as of 2005). SWX Swiss Exchange is Switzerlands stock exchange. ... 2005 (MMV) was a common year starting on Saturday of the Gregorian calendar. ... Novartis Suffern plant is the Swiss companys sole pharmaceutical production facility in the U.S. Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland. ...


Founded in 1896 by Fritz Hoffmann-La Roche, the company was early on known for producing various vitamin preparations and derivatives. In 1957 it introduced the class of tranquilizers known as benzodiazepines (with Valium and Rohypnol being the best known members). Its acne drug isotretinoin marketed as Accutane® and Roaccutane® is a market leader in treating severe acne. It has also produced various HIV tests and antiretroviral drugs. It bought the patents for the important polymerase chain reaction technique in 1992. It manufactures several cancer drugs. 1896 (MDCCCXCVI) was a leap year starting on Wednesday (see link for calendar). ... Retinol (Vitamin A) Vitamins are nutrients required for essential metabolic reactions in the body [1]. Vitamins can act both as catalysts and participants in chemical reactions. ... 1957 (MCMLVII) was a common year starting on Tuesday of the Gregorian calendar. ... A sedative is a drug that depresses the central nervous system (CNS), which causes calmness, relaxation, reduction of anxiety, sleepiness, slowed breathing, slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes. ... alprazolam 2mg tablets The benzodiazepines are a class of drugs with sedative, hypnotic, anxiolytic, anticonvulsant, amnestic and muscle relaxant properties. ... Diazepam, brand names: Valium, Seduxen, in Europe Apozepam, is a 1,4-benzodiazepine derivative, which possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. ... Rohypnol (the trade name of flunitrazepam) is a sedative that was made in the early 1970s by Roche and was used in hospitals only for deep sedation. ... Isotretinoin (INN) (IPA: ) is a medication used for the treatment of severe acne. ... U.S. Global AIDS Coordinator, Randal Tobias, is being publicly tested for HIV/AIDS in Ethiopia, in an effort to reduce the stigma of being tested. ... Antiretroviral drugs are medications for the treatment of infection by retroviruses, primarily HIV. Different classes of antiretroviral drugs act at different stages of the HIV life cycle. ... A patent is a set of exclusive rights granted by a state to a person for a fixed period of time in exchange for the regulated, public disclosure of certain details of a device, method, process or composition of matter (substance) (known as an invention) which is new, inventive, and... Polymerase chain reaction (PCR) is a molecular biology technique, invented in 1985 by Kary B. Mullis,[1] for enzymatically replicating DNA without using a living organism, such as E. coli or yeast. ... 1992 (MCMXCII) was a leap year starting on Wednesday. ... Cancer is a class of diseases or disorders characterized by uncontrolled division of cells and the ability of these cells to invade other tissues, either by direct growth into adjacent tissue through invasion or by implantation into distant sites by metastasis. ...


In 1976, an accident at a chemical factory in Seveso (Italy) owned by a subsidiary of Roche caused a large dioxin contamination; see Seveso disaster. 1976 (MCMLXXVI) was a leap year starting on Thursday. ... Seveso is an Italian town and comune of 19,872 inhabitants situated in the Province of Milan, in the Region of Lombardy. ... Structure of 2,3,7,8- tetrachlorodibenzo- p-dioxin (TCDD) Dioxin is the popular name for the family of halogenated organic compounds, the most common consisting of polychlorinated dibenzofurans (PCDFs) and polychlorinated dibenzodioxins (PCDDs). ... The Seveso disaster was an industrial accident that occurred in Seveso, Italy on July 10, 1976 in a small chemical manufacturing plant of ICMESA. During the production of 2,4,5-trichlorophenol, a herbicide, fungicide, and chemical intermediate, an uncontrolled reaction occurred and the chemical reactor ruptured. ...

Contents


Vitamin price-fixing

In 1973, Stanley Adams, Roche's World Product Manager in Basel, contacted the EEC with evidence that Roche had been breaking anti-trust laws, engaging in price-fixing and market sharing with its competitors. Roche was fined accordingly, but unfortunately a bungle on the part of the EEC allowed the company to discover that it was Adams who had blown the whistle. He was arrested for unauthorised disclosure - an offence under Swiss law - and imprisoned. His wife, told that he might face decades in jail, committed suicide. Adams was released soon after but arrested again more than once before eventually fleeing to Britain, where he wrote a book about the affair. 1973 (MCMLXXIII) was a common year starting on Monday. ... Possible meanings: Energy Efficiency Centre Energy Efficiency in Construction Engineering Education Centre Eurocontrol Experimental Centre European Economic Community, former name of the now-called European Community European Egg Consortium Extended Error Correction, see RAM parity This page concerning a three-letter acronym or abbreviation is a disambiguation page — a navigational...


In 1999 Roche was the world-wide market leader in vitamins, with a market share of 40%. Between 1990 and 1999, the company participated in an illegal price fixing cartel for vitamins. Other members of the cartel were BASF and Rhone-Poulenc SA. In 1999, Roche pleaded guilty in the United States and paid a $500 million fine, then the largest fine ever secured in the U.S. The European Commission fined Roche 462 million euros for the same infraction in 2001, also a record fine at the time. 1999 (MCMXCIX) was a common year starting on Friday, and was designated the International Year of Older Persons by the United Nations. ... 1999 (MCMXCIX) was a common year starting on Friday, and was designated the International Year of Older Persons by the United Nations. ... BASF AG (NYSE: BF, LSE: BFA) is a German chemical company and the biggest chemical company in the world. ... The European Commission (formally the Commission of the European Communities) is the executive body of the European Union. ... ISO 4217 Code EUR User(s) European Union; Austria, Belgium, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Portugal, Spain, Andorra, Monaco, San Marino, Vatican City, Montenegro, Kosovo, French Guiana, Réunion, Saint-Pierre et Miquelon, Guadeloupe, Martinique, Mayotte. ... 2001: A Space Odyssey. ...


Roche sold its vitamin business in late 2002 to the Dutch group DSM. DSM (in full Koninklijke DSM N.V., or Royal DSM N.V.) is a multinational chemicals company. ...


Bird flu antidote monopoly

In a recent meeting of regional health ministers, Dr. Francisco Duque III, Secretary of the Philippines Department of Health, accused Roche of "monopolizing" the production and distribution of the drug known as Oseltamivir (brand name Tamiflu). Oseltamivir is considered to be the primary antiviral drug used to combat avian influenza, commonly known as the bird flu. Roche is the only drug company authorized to manufacture the drug, which was discovered by Gilead Sciences. Roche purchased the rights to the drug in 1996 and in 2005 settled a royalty dispute, agreeing to pay Gilead tiered royalties of 14-22% of annual net sales.[1] Tamiflu manufactured by ROCHE active principle Oseltamivir Phosphate Drug Nomenclature Synonyms: GS-4104/002; Oseltamivir, fosfato de; Ro-64-0796/002 USAN: Oseltamivir Phosphate rINNM: Oseltamivir Phosphate erINNM: Fosfato de oseltamivir Chemical name: Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (1... Avian influenza (also known as bird flu) is a type of influenza virulent in birds. ... Gilead Sciences NASDAQ: GILD is a biopharmaceutical company that discovers, develops and commercializes therapeutics to advance the care of patients suffering from life-threatening diseases, principally HIV, hepatitis B and influenza. ...


The Philippine health secretary complained that the supply of the said drug is only concentrated in First World countries even if the disease is ravaging bird and poultry populations in Southeast Asia as of this time. Dr. Duque proposed that even if Roche is the only one who has the patent for the drug, special patents or licenses should be granted to other drug companies to manufacture the drug and make it more accessible to avian flu-vulnerable countries in Southeast Asia such as Vietnam, Indonesia, Cambodia and the Philippines. Duque and Philippine president Gloria Macapagal Arroyo has already communicated with the representative of the World Health Organization in the Philippines asking for assistance in calling for greater production and distribution of Oseltamivir. The terms First World, Second World, and Third World were used to divide the nations of Earth into three broad categories. ... Location of Southeast Asia Southeast Asia is a subregion of Asia. ... PRESIDENT OF THE PHILIPPINES Gloria Macapagal-Arroyo Gloria Macapagal-Arroyo (born April 5, 1947), also known by her initials GMA, is the current and 14th President of the Republic of the Philippines. ... Flag of World Health Organization The World Health Organization (WHO) is a specialized agency of the United Nations, acting as a coordinating authority on international public health, headquartered in Geneva, Switzerland. ...

Wikinews has news related to:
Taiwan to violate Tamiflu patent in order to compensate for vaccine shortage

World leaders, such as UN Secretary General Kofi Annan, have expressed a desire to have more generic versions of Tamiflu made, especially for Third World countries too poor to buy the brand name drug. Image File history File links Wikinews-logo. ... Wikinews is a free-content news source and a project of the Wikimedia Foundation. ... The United Nations Secretary-General is the head of the Secretariat, one of the principal divisions of the United Nations. ... This article or section does not cite its references or sources. ... For the Jamaican reggae band, see Third World (band). ...


On October 20, 2005 Hoffmann-La Roche decided they would license other companies to manufacture Oseltamivir.


Additional key persons

In addition to key executives mentioned in the summary information box

  • Rebecca Taub, Vice President Research, Metabolic Diseases (source: "Obesity Drug Development Summit" conference program, sponsored by the Center for Business Intelligence, held July 2005, Arlington, VA, USA)

Company profiles

References

  1. ^ "Roche, Gilead End Tamiflu Feud", Red Herring, November 16, 2005.

  Results from FactBites:
 
Hoffmann-La Roche - Wikipedia, the free encyclopedia (718 words)
Roche Holding AG (ticker ROC.S) is listed on the London-based virt-x stock exchange (virt-x is a company of the SWX_Swiss_Exchange).
Roche's revenues during fiscal year 2002 were $9400 million, ranking 13th amongst the pharmaceutical companies of the world.
Roche was fined accordingly, but unfortunately a bungle on the part of the EEC allowed the company to discover that it was Adams who had blown the whistle.
Hoffmann-La Roche - definition of Hoffmann-La Roche in Encyclopedia (264 words)
Founded in 1896 by Fritz Hoffmann-La Roche, the company was early on known for producing various vitamin preparations and derivatives.
In 1999, Roche plead guilty in the U.S. and paid a $500 million fine, then the largest fine ever secured in the U.S. The European Commission fined Roche 462 million euros for the same infraction in 2001, also a record fine at the time.
Roche Holding AG is publicly traded over the counter through the pink sheets with stock symbol RHHBF.PK.
  More results at FactBites »

 
 

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