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Encyclopedia > Rituximab
Image:Rituximab.png
Rituximab
Systematic (IUPAC) name
Chimeric murine/human monoclonal anti-CD20 antibody
Identifiers
CAS number 174722-31-7
ATC code L01XC02
PubChem  ?
DrugBank BTD00014
Chemical data
Formula C6416H9874N1688O1987S44
Mol. weight 143859.7 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Overview of the citric acid cycle The citric acid cycle, one of the central metabolic pathways in aerobic organisms. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Rituximab, sold under the trade names Rituxan® and MabThera®, is a monoclonal antibody used in the treatment of B cell non-Hodgkin's lymphoma, B cell leukemia, and some autoimmune disorders. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Monoclonal antibodies (mAb) are antibodies that are identical because they were produced by one type of immune cell, all clones of a single parent cell. ... B cells are lymphocytes that play a large role in the humoral immune response (as opposed to the cell-mediated immune response). ... Non-Hodgkins lymphoma is a type of cancer. ... HI CAMOIN thIS IS YOUR FRIEND CJ Leukemia (leukaemia in British English) is a cancer of the blood or bone marrow and is characterized by an abnormal proliferation of blood cells, usually white blood cells (leukocytes). ... Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. ...

Contents

History

Rituximab was developed by IDEC Pharmaceuticals and initially approved by the FDA in 1997 for lymphoma that was refractory to other chemotherapy regimens. The original approval followed the availability of the McLaughlin et al[1] study data. It now is standard therapy in the initial treatment of aggressive lymphomas (e.g. diffuse large B cell lymphoma) in combination with CHOP chemotherapy. It is currently co-marketed by Biogen Idec and Genentech in the U.S. market and Roche in the EU. B-cell lymphoma is a type of non-Hodgkin lymphoma affecting B cells. ... CHOP is the acronym for a chemotherapy regimen used in the treatment of non-Hodgkin lymphoma. ...


Mechanism

The antibody binds to the cluster of differentiation 20 (CD20) found on the surface of B cells, flagging them for destruction by the body's own immune system. This eliminates B cells (including the cancerous ones) from the body, allowing a new population of healthy B cells to develop from lymphoid stem cells. The actual mechanisms for Rituximab to eliminate B cells includes the induction of ADCC, CDC, and apoptosis. The introduction to this article provides insufficient context for those unfamiliar with the subject matter. ... CD20 is a non-glycosylated phosphoprotein expressed on the surface of all mature B-cells. ... Mouse embryonic stem cells with fluorescent marker. ... ADCC may refer to: ADCC (Abu Dhabi Combat Club) Submission Wrestling Championship. ... CDC is an abbreviation which can mean any of the following: Canucks Dot Com Centers for Disease Control and Prevention Communicable Disease Control Community of Democratic Choice, a group of nine Eastern-European states Change data capture, in data warehousing Clock Domain Crossing, or simply clock-crossing in computing Cedar... A cell undergoing apoptosis. ...


Binder et al further described the part of the CD20 molecule that rituximab binds to: it turned out to be amino acids 170-173 and 182-185, which are physically close to each other as a result of a disulfide bond between amino acids 167 and 183.[2] Phenylalanine is one of the standard amino acids. ... In chemistry, a disulfide bond is a single covalent bond derived from the coupling of thiol groups. ...


Non-cancer use

Rituximab has been found to be effective in the treatment of immune thrombocytopenic purpura (ITP) in various trials.[3] It also seems to be effective in threatment of systemic lupus erythematosus and rheumatoid arthritis.[citation needed]Rituximab has also been found to be effective in the treatment of Acquired pure red cell aplasia (PRCA). Rituxan is FDA-approved for use in combination with methotrexate (MTX) for reducing signs and symptoms in adult patients with moderately- to severely-active rheumatoid arthritis (RA) who have had an inadequate response to one or more tumor necrosis factor (TNF) antagonist therapies Idiopathic thrombocytopenic purpura is the condition of having a low platelet count (thrombocytopenia) of no known cause (idiopathic). ... Acquired pure red cell aplasia (or PRCA) refers to a type of anemia affecting the precursors to red blood cells but not to white blood cells. ...


Transplant use

Rituximab is now being used in the management of Renal Transplant recipients. This drug is especially useful in transplants involving incompatible blood groups. It is also used as induction therapy in highly sensitized patients going for renal transplantation.


External link

  • Mabthera.com
  • [1]

References

  1. ^ McLaughlin P, Grillo-Lopez AJ, Link BK, Levy R, Czuczman MS, Williams ME, Heyman MR, Bence-Bruckler I, White CA, Cabanillas F, Jain V, Ho AD, Lister J, Wey K, Shen D, Dallaire BK. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J Clin Oncol 1998;16:2825-33. PMID 9704735.
  2. ^ Binder M, Otto F, Mertelsmann R, Veelken H, Trepel M. (2006). "The epitope recognized by rituximab.". Blood 108: 1975-1978. PMID 16705086.
  3. ^ Braendstrup P, Bjerrum OW, Nielsen OJ, Jensen BA, Clausen NT, Hansen PB, Andersen I, Schmidt K, Andersen TM, Peterslund NA, Birgens HS, Plesner T, Pedersen BB, Hasselbalch HC. Rituximab chimeric anti-CD20 monoclonal antibody treatment for adult refractory idiopathic thrombocytopenic purpura. Am J Hematol 2005;78:275-80. PMID 15795920.


Chemotherapeutic agents/Antineoplastic agents (L01) edit - Chemotherapy regimens
Alkylating agents:

Nitrogen mustards: (Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan). Nitrosoureas: (Carmustine, Fotemustine, Lomustine, Streptozocin). Platinum: (Carboplatin, Cisplatin, Oxaliplatin, BBR3464). Busulfan, Dacarbazine, Mechlorethamine, Procarbazine, Temozolomide, ThioTEPA, Uramustine Chemotherapy is the use of chemical substances to treat disease. ... A section of the Anatomical Therapeutic Chemical Classification System. ... Chemotherapy regimens are often identified with acronyms, identifying the agents used in combination. ... Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. ... The nitrogen mustards are cytotoxic chemotherapy agents similar to mustard gas. ... Chlorambucil (marketed as Leukeran by GlaxoSmithKline) is a chemotherapy drug that has been mainly used in the treatment of chronic lymphocytic leukemia. ... Mechlorethamine also known as chlormethine, mustine, nitrogen mustard and HN2 and sold under the brand name Mustargen, is the prototype anticancer chemotherapeutic drug. ... Cyclophosphamide (the generic name for Cytoxan, Neosar) is a nitrogen mustard alkylating agent, used to treat various types of cancer and some autoimmune disorders. ... Ifosfamide (Mitoxana®) Ifosfamide (pronounced i fos fa mide) is chemotherapy that is given as a treatment for many different types of cancer. ... Melphalan hydrochloride ( Alkeran®) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents. ... Urea streptozotocin ENU Nitrosourea compounds are compounds that include a nitroso (R-NO) group and a urea. ... Carmustine is an nitrosourea compound used as an alkylating agent in chemotherapy. ... Fotemustine is a nitrosourea alkylating agent. ... Lomustine (or CCNU) is an alkylating nitrosourea compound used in chemotherapy. ... Streptozotocin (Streptozocin, STZ, Zanosar) is a naturally occurring chemical that is paticularly toxic to the insulin-producing beta cells of the pancreas in mammals. ... General Name, Symbol, Number platinum, Pt, 78 Chemical series transition metals Group, Period, Block 10, 6, d Appearance grayish white Atomic mass 195. ... Carboplatin is a chemotherapy drug used against some forms of cancer. ... Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e. ... Oxaliplatin - Wikipedia /**/ @import /w/skins-1. ... There are very few or no other articles that link to this one. ... Busulfan is a chemotherapy drug that is an alkylating agent. ... Dacarbazine (da-KAR-ba-zeen) (brand names DTIC, DTIC-Dome; also known as DIC or Imidazole Carboxamide) is an antineoplastic chemotherapy drug used in the treatment of various cancers, among them malignant melanoma (a form of skin cancer which can spread to other parts of the body). ... Mechloretamine: chemical structure Mechlorethamine also known as nitrogen mustard and HN2 and sold under the brand name Mustargen, is the first anticancer drug to be widely used clinically. ... Procarbazine (Matulane® (US), Natulan (Canada)) is an antineoplastic chemotherapy drug for the treatment of Hodgkins lymphoma and certain brain cancers (such as Glioblastoma multiforme). ... Temozolomide (brand name Temodar® Schering-Plough Corporation) is an oral alkylating agent used for the treatment of refractory anaplastic astrocytoma -- a type of cancerous brain tumor. ... N,NN-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. ... Uracil mustard or uramustine is a chemotherapy drug which belongs to the class of alkylating agents. ...

Antimetabolites:

Folic acid: (Aminopterin, Methotrexate, Pemetrexed, Raltitrexed). Purine: (Cladribine, Clofarabine, Fludarabine, Mercaptopurine, Thioguanine). Pyrimidine: (Capecitabine, Cytarabine, Fluorouracil, Gemcitabine) An antimetabolite is a chemical with a similar structural to a substance (a metabolite) required for normal biochemical reactions, yet different enough to interfere with the normal functions of cells, including cell division. ... Folic acid and folate (the anion form) are forms of the water-soluble Vitamin B9. ... Aminopterin is commonly misinterpreted as Methotrexate, an anti cancer drug. ... Methotrexate (rINN) (IPA: ), abbreviated MTX and formerly known as amethopterin, is an antimetabolite drug used in treatment of cancer and autoimmune diseases. ... Pemetrexed chemical structure Pemetrexed (brand name Alimta) is a chemotherapy drug. ... Raltitrexed (brand name Tomudex®) is a chemotherapy drug manufactured AstraZeneca Company, is an antimetabolite used in chemotherapy. ... Purine is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. ... Cladribine is a drug used to treat hairy cell leukemia (leukemic reticuloendotheliosis). ... Clofarabine: chemical structure Clofarabine is a substance that is being studied in the treatment of cancer. ... Fludarabine is a chemotherapy drug used in the firstline treatment of chronic lymphocytic leukemia. ... Mercaptopurine: chemical structure Mercaptopurine (also called 6-MP or by its brand name Purinethol®) is an immunosuppressive drug used to treat leukemia. ... Tioguanine (INN), formerly Thioguanine (BAN), is a drug that is used in the treatment of cancer. ... Pyrimidine is a heterocyclic aromatic organic compound similar to benzene and pyridine, containing two nitrogen atoms at positions 1 and 3 of the six-member ring [1]. It is isomeric with two other forms of diazine. ... Xeloda Logo Capecitabine (brand name: Xeloda®) is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. ... Cytarabine is a shortened form of cytosine arabinoside, a commonly used chemotherapy agent used mainly in the treatment of leukemia and non-Hodgkin lymphoma. ... Fluorouracil (5-FU) is a drug that is used in the treatment of cancer. ... Gemcitabine is a nucleoside used as chemotherapy. ...

Plant alkaloids:

Taxane: (Docetaxel, Paclitaxel). Vinca: (Vinblastine, Vincristine, Vindesine, Vinorelbine). Diagram of Ephedrine An alkaloid, strictly speaking, is a naturally-occurring amine produced by a plant,[1] but amines produced by animals and fungi are also called alkaloids. ... The taxanes are NOT alkaloids (not every molecule coming from a plant and bearing a nitrogen is an alkaloid!). They are diterpenes produced by the plants of the genus Taxus (yews). ... Docetaxel chemical structure Docetaxel is a chemotherapy drug used in the treatment of cancer. ... Paclitaxel (Taxol®) is a drug used in the treatment of cancer. ... Vinca is Vinca, a botanical genus; see Periwinkle (plant). ... Vinblastine is a drug used to treat certain kinds of cancer, including Hodgkins lymphoma, non-small cell lung cancer and breast cancer or testicular cancer. ... Vincristine (Oncovin®) is a vinca alkaloid from the Madagascar periwinkle (Catharanthus roseus, formerly Vinca rosea and hence its name). ... Vindesine is a vinca alkaloid used in chemotherapy. ... Vinorelbine (Navelbine) is a chemotherapy drug that is given as a treatment for some types of cancer including breast cancer and non-small-cell lung cancer. ...

Cytotoxic/antitumor antibiotics:

Anthracycline family: (Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitoxantrone, Valrubicin). Bleomycin, Hydroxyurea, Mitomycin herbs that have the specific action of inhibiting and combating the development of tumors. ... Anthracycline - Wikipedia, the free encyclopedia /**/ @import /skins-1. ... Daunorubicin is chemotherapy that is given as a treatment for some types of cancer. ... Doxorubicin or adriamycin or hydroxyldaunorubicin is a DNA-interacting drug widely used in chemotherapy. ... Epirubicin is an anthracycline drug used for chemotherapy. ... Idarubicin chemical structure Idarubicin or 4-demethoxydaunorubicin is an anthracycline drug that is used in the treatment of cancer. ... Mitoxantrone belongs to the general group of medicines known as antineoplastics, specifically the anthracycline class. ... Valrubicin chemical structure Valrubicin (N-trifluoroacetyladriamycin-14-valerate, Valstar®) is a chemotherapy drug used to treat bladder cancer. ... Bleomycin is an anti-cancer agent. ... Hydroxyurea chemical structure Hydroxyurea or hydroxycarbamide (rINN), (brand names include Hydrea®) is an antineoplastic drug used in hematological malignancies. ... Mitomycin or mitomycin C is a form of chemotherapy given intravenously to treat upper gastro-intestinal (e. ...

Topoisomerase inhibitors:

Topotecan, Irinotecan, Podophyllum: (Etoposide, Teniposide). Topoisomerases (type I: EC 5. ... Topotecan (Hycamtin®) is a chemotherapy agent that is a topoisomerase 1 inhibitor. ... Irinotecan is a chemotherapy agent that is a topoisomerase 1 inhibitor. ... Binomial name Podophyllum peltatum L. The American Mayapple (Podophyllum peltatum) is a herbaceous perennial plant in the family Berberidaceae, native to the eastern part of North America. ... Etoposide: chemical structure Etoposide phosphate (Eposin®, Etopophos®, Vepesid®, VP-16®) is an inhibitor of the enzyme topoisomerase II. It is used as a form of chemotherapy for malignancies such as lung cancer, testicular cancer, lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme. ... Teniposide is a prescribed medication mainly used to treat childhood acute lymphocytic leukemia. ...

Monoclonal antibodies:

Alemtuzumab, Bevacizumab, Cetuximab, Gemtuzumab, Panitumumab, Rituximab, Tositumomab, Trastuzumab Monoclonal antibodies (mAb) are antibodies that are identical because they were produced by one type of immune cell, all clones of a single parent cell. ... Alemtuzumab (marketed as Campath or Campath-1H) is a monoclonal antibody used in the treatment of chronic lymphocytic leukemia (CLL) and T-cell lymphoma. ... Bevacizumab (Avastin®) is an anti-angiogenesis drug used in treatment of cancer. ... Cetuximab (Erbitux®) is a chimeric monoclonal antibody given by intravenous injection for treatment of colorectal cancer. ... Gemtuzumab ozogamicin (marketed as Mylotarg) is a monoclonal antibody used to treat acute myelogenous leukemia. ... It is proposed that this article be deleted, because of the following concern: No references or indication of notability. ... Tositumomab is a monoclonal antibody. ... Herceptin Logo Trastuzumab (Herceptin®) is an anti-cancer therapy that acts on the HER2/neu (erbB2) receptor. ...

Photosensitizers:

Aminolevulinic acid, Methyl aminolevulinate, Porfimer sodium, Verteporfin A photosensitizer is a chemical compound, used in the Photodynamic Therapy of cancers, that can be excited by light of a specific wavelength. ... D-Aminolevulinic acid (dALA or δ-ALA or 5-aminolevulinic acid) is the first compound in the porphyrin synthesis pathway. ... Methyl aminolevulinate is a sensitizer used in photodynamic/radiation therapy. ... Porfimer is a sensitizer used in photodynamic/Radiation therapy. ... Verteporfin, otherwise known as benzoporphyrin derivative (Visudyne®), is a medication used in conjunction with laser treatment to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration. ...

Kinase inhibitors:

Dasatinib, Erlotinib, Gefitinib, Imatinib, Lapatinib, Nilotinib, Sorafenib, Sunitinib, Vandetanib (ZD6474) Dasatinib is a drug produced by Bristol-Myers Squibb and sold under the trade name Sprycel®. Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinases inhibitor approved for use in patients with chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). ... Erlotinib hydrochloride (trade name Tarceva®, Genentech/OSIP) is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. ... Gefitinib is a new drug used in the treatment of certain types of cancer. ... Imatinib is a drug used to treat certain types of cancer. ... There are very few or no other articles that link to this one. ... There are very few or no other articles that link to this one. ... Sorafenib (marketed as Nexavar by Bayer) is a drug used for the treatment of advanced renal cell cancer. ... Sunitinib (marketed as Sutent, previously known as SU11248) is a small molecule receptor tyrosine kinase inhibitor that is used in the treatment of gastrointestinal stromal tumor (GIST) as well as renal cell carcinoma (RCC). ... Vandetanib (rINN, trade name Zactima®), also known as ZD6474, is a medication currently undergoing clinical trials as a potential targeted treatment for non–small-cell lung cancer. ...

Other:

Alitretinoin, Altretamine, Amsacrine, Anagrelide, Arsenic trioxide, Asparaginase, Bexarotene, Bortezomib, Denileukin diftitox, Estramustine, Hydroxycarbamide, Pentostatin, Masoprocol, Mitotane, Pegaspargase, Tretinoin Alitretinoin is an antineoplastic agent. ... Altretamine (also hexalen) is a drug that is used to treat ovarian cancer. ... Amsacrine is an antineoplastic agent. ... Anagrelide (Agrylin®/Xagrid®, Shire) is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia). ... R-phrases , , , S-phrases , , , Supplementary data page Structure and properties n, εr, etc. ... Asparaginase (EC 3. ... Bexarotene is an antineoplastic agent. ... Bortezomib (VelcadeTM) is a first-in-class proteasome inhibitor. ... Denileukin diftitox is an antineoplastic agent. ... Estramustine (Emcyt®) is a chemotherapy agent used to treat prostate cancer. ... Hydroxyurea or hydroxycarbamide (brand names include Hydrea®) is an antineoplastic drug used in hematological malignancies. ... Pentostatin (Deoxycoformycin) is an anticancer chemotherapeutic drug. ... Masoprocol is an antineoplastic agent. ... Mitotane is a substance used for the rare disease adrenocortical carcinoma. ... Pegaspargase is an antineoplastic agent. ... Tretinoin is the acid form of vitamin A and so also known as all-trans retinoic acid or ATRA. It is a drug commonly used to treat acne vulgaris and keratosis pilaris. ...


[edit]Chimeric monoclonal antibodies

Abciximab, Basiliximab, Bavituximab, Cetuximab, Clenoliximab, Ecromeximab, Galiximab, Gomiliximab, Infliximab, Keliximab, Lumiliximab, Pagibaximab, Rituximab, Teneliximab, Vapaliximab, Volociximab A Chimera (or chimeric protein) is a human-engineered or in vivo mutated protein that is encoded by a nucleotide sequence made by a splicing together of two or more complete or partial genes or cDNA. The pieces used may be from different species. ... Monoclonal antibodies (mAb) are antibodies that are identical because they were produced by one type of immune cell, all clones of a single parent cell. ... Abciximab (previously known as c7E3 Fab), distributed by Eli Lilly under the trade name ReoPro®, is a platelet aggregation inhibitor mainly used during and after coronary artery procedures like angioplasty to prevent platelets from sticking together and causing thrombus (blood clot) formation within the coronary artery. ... Basiliximab (Simulect) is a chimeric mouse-human monoclonal antibody to the IL-2Rα receptor of T cells. ... Bavituximab is a chimeric monoclonal antibody which its used to treat cancers. ... Cetuximab (Erbitux®) is a chimeric monoclonal antibody given by intravenous injection for treatment of colorectal cancer. ... Clenoliximab is an immunosuppressive drug. ... Ecromeximab is a chimeric monoclonal antibody is used to treat melanomas. ... Galiximab is a chimeric monoclonal antibody which its used as an immunosuppressive drug. ... Gomiliximab is a chimeric monoclonal antibody which its used as an immunosuppressive drug. ... It has been suggested that Infliximab (Remicade) be merged into this article or section. ... Keliximab is a chimeric monoclonal antibody which its used as an immunosuppressive drug. ... Lumiliximab is a chimeric monoclonal antibody which its used as an immunosuppressive drug. ... Teneliximab is a chimeric monoclonal antibody which its used as an immunosuppressive drug. ... Vapaliximab is a chimeric monoclonal antibody which its used as an immunosuppressive drug. ...


  Results from FactBites:
 
MedlinePlus Drug Information: Rituximab Injection (1264 words)
When rituximab is used to treat non-Hodgkin's lymphoma (NHL; a type of cancer that begins in a type of white blood cells that normally fight infection) it may cause a condition called tumor lysis syndrome (TLS; a group of symptoms caused by the fast breakdown of cancer cells).
Rituximab is used alone or with other medications to treat certain types of non-Hodgkin's lymphoma (NHL; a type of cancer that begins in a type of white blood cells that normally fights infection).
Rituximab is also used with another medication to treat the symptoms of rheumatoid arthritis (RA; a condition in which the body attacks its own joints, causing pain, swelling, and loss of function) in people who have already been treated with a certain type of medication called a tumor necrosis factor (TNF) inhibitor.
Rituximab (526 words)
Rituximab belongs to a group of medications known as monoclonal antibodies.
Rituximab is used in combination with other chemotherapy medications to treat non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL).
Rituximab should be administered only under the supervision of a medical oncologist or hematologist.
  More results at FactBites »

 
 

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