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Encyclopedia > Ritonavir

Ritonavir is a drug from the protease inhibitor class used to treat AIDS. It is manufactured as Norvir® by Abbott Laboratories. Research that led to the drug's development was financed in part by a $3,500,000 grant from United States taxpayers through the National Institutes of Health. Many drugs are provided in tablet form. ... Protease inhibitors are a class of medication used to treat or prevent viral infections. ... AIDS (Acquired Immunodeficiency Syndrome or Acquired Immune Deficiency Syndrome, sometimes written Aids) is a human disease characterized by weakening of the bodys immune system and capacity to fight infection and certain cancers. ... Abbott Laboratories (NYSE: ABT) is a pharmaceuticals and health care company. ... The National Institutes of Health is an institution of the United States government which focuses on medical research. ...

In 2003, Abbott raised the price of a Norvir course from $1.71 per day to $8.57 per day, leading to claims of price gouging by patients' groups and some members of Congress. Consumer group Essential Inventions petitioned the NIH to override the Norvir patent, but the NIH announced on August 4, 2004 that it will not invoke its legal right to allow generic production of Norvir, citing potential adverse effects on the pharmaceutical market. 2003 is a common year starting on Wednesday of the Gregorian calendar. ... August 4 is the 216th day of the year in the Gregorian Calendar (217th in leap years), with 149 days remaining. ... 2004 is a leap year starting on Thursday of the Gregorian calendar. ... Pharmacology (in Greek: pharmacon is drug, and logos is science) is the study of how chemical substances interfere with living systems. ...

External links

  • NIH Won't Intervene in AIDS Drug Pricing Issue (http://www.washingtonpost.com/wp-dyn/articles/A40430-2004Aug4.html)

  Results from FactBites:
ritonavir - HIV: health and medical information about HIV and AIDS (751 words)
Ritonavir blocks the activity of protease and results in the formation of defective viruses that are unable to infect the body's cells.
Ritonavir should not be used together with amiodarone (Cordarone), quinidine (Quinaglute, Cardioquin), triazolam (Halcion), midazolam (Versed), pimozide (Orap), propafenone (Rythmol) and flecainide (Tambocor) because ritonavir increases the blood levels of these drugs and may lead to serious side effects.
Ritonavir may increase the blood concentration of lovastatin (Mevacor), simvastatin (Zocor), atorvastatin (Lipitor) and cerivastatin (Baycol).
Ritonavir (Norvir) | The New Mexico AIDS InfoNet (872 words)
Ritonavir is taken by mouth as a liquid or capsule.
Ritonavir was approved for use by children over 1 month old at a dose of 350 mg to 450 mg per square meter of body area.
Ritonavir is mostly used to increase the blood levels of other protease inhibitors.
  More results at FactBites »



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