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Encyclopedia > Rimantadine

Rimantadine (systematic name 1-(1-aminoethyl)adamantane) is an orally administered medicine used to treat, and in rare cases prevent, Influenzavirus A infection. When taken within one to two days of developing symptoms, rimantadine can shorten the duration and moderate the severity of influenza. It is a derivate of adamantane, like a similar drug amantadine. It was approved by the FDA in 1994. Image File history File links Rimantadine. ... Medicine is the branch of health science and the sector of public life concerned with maintaining human health or restoring it through the treatment of disease and injury. ... Influenzavirus A is a genus of a family of viruses called Orthomyxoviridae in virus classification. ... Adamantane (Tricyclo[3. ... Amantadine, 1-aminoadamantane, is an antiviral drug that was approved by the FDA in 1976 for the treatment of influenza type A in adults. ... The United States Food and Drug Administration is the government agency responsible for regulating food, dietary supplements, drugs, cosmetics, medical devices, biologics and blood products in the United States. ...

Contents


Mechanics

Scientists do not understand why rimantadine works, but believe it inhibits influenza's viral replication, possibly by preventing the uncoating of the virus's protective shells, which are the envelope and capsid. Genetic studies suggest that a virus M2 protein, an ion channel specified by virion M2 gene plays an important role in the susceptibility of influenza A virus to inhibition by rimantadine. The human immunodeficiency virus (HIV) A bacteriophage virus A virus is a submicroscopic parasite that infects cells in biological organisms. ... The human immunodeficiency virus (HIV) A bacteriophage virus A virus is a submicroscopic parasite that infects cells in biological organisms. ... The M2 protein is a proton-selective ion channel protein, integral in the cell membrane of the influenza A virus. ... Another, unrelated ion channeling process is part of ion implantation. ... This stylistic schematic diagram shows a gene in relation to the double helix structure of DNA and to a chromosome (right). ...


Drug interactions

Taking acetaminophen (Tylenol) or aspirin while taking rimantadine is known to reduce the body's uptake of rimantadine by approximately 12%.[1] Cimetidine also affects the body's uptake of rimantadine. Acetaminophen (USAN) or paracetamol (INN), is a popular analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. ... Tylenol (paracetamol, also known as acetaminophen) is a popular American brand of pain reliever and fever reducer, sold by Johnson & Johnson. ... Aspirin or acetylsalicylic acid is a drug in the family of salicylates, often used as an analgesic (against minor pains and aches), antipyretic (against fever), and anti-inflammatory. ... Cimetidine is a histamine H2-receptor antagonist that inhibits the production of acid in the stomach. ...


Adverse effects

Rimantadine can produce gastrointestinal and central nervous system adverse effects. Studies have shown it produces fewer side effects than other anti-viral influenza treatments. Approximately 6% of patients (compared to 6% of patients taking a placebo) reported side effects.[2] Common side effects include: For the Physics term GUT, please refer to Grand unification theory The gastrointestinal or digestive tract, also referred to as the GI tract or the alimentary canal or the gut, is the system of organs within multicellular animals which takes in food, digests it to extract energy and nutrients, and... A diagram showing the CNS: 1. ... Adverse effect, in medicine, is an abnormal, harmful, undesired and/or unintended side-effect, although not necessarily unexpected, which is obtained as the result of a therapy or other medical intervention, such as drug/chemotherapy, physical therapy, surgery, medical procedure, use of a medical device, etc. ...

  • nausea
  • upset stomach
  • nervouseness
  • tiredness
  • lightheadedness
  • trouble sleeping
  • difficulty concentrating

For other uses, see Nausea (disambiguation). ...

External links

  • U.S. FDA press release announcing rimantadine's approval
  • U.S. Center for Drug Evaluation and Research rimantadine description
  • U.S. NIH rimantadine description
  • U.S. CDC flu anti-viral treatment information


Antivirals (ATC J05A) edit
Anti-herpesvirus agents   Acyclovir · Cidofovir · Docosanol · Famciclovir · Foscarnet · Fomivirsen · Ganciclovir · Idoxuridine · Penciclovir · Trifluridine · Tromantadine · Valaciclovir · Valganciclovir · Vidarabine
Anti-influenza agents Amantadine · Oseltamivir · Peramivir · Rimantadine · Zanamivir
 
Antiretroviral drugs   NRTIs Zidovudine · Didanosine · Stavudine · Zalcitabine · Lamivudine · Abacavir · Tenofovir
NNRTIs   Nevirapine · Efavirenz · Delavirdine
PIs Saquinavir · Indinavir · Atazanavir · Ritonavir · Nelfinavir · Amprenavir · Lopinavir · Tipranavir
 
Other antiviral agents Fomivirsen · Enfuvirtide · Imiquimod · Interferon · Ribavirin · Viramidine

 
 

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