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Encyclopedia > Retinoid X receptor
retinoid X receptor, alpha
Identifiers
Symbol(s) RXRA
Entrez 6256
OMIM 180245
RefSeq NM_002957
UniProt P19793
Other data
Locus Chr. 9 q34
retinoid X receptor, beta
Identifiers
Symbol(s) RXRB
Entrez 6257
OMIM 180246
RefSeq NM_021976
UniProt P28702
Other data
Locus Chr. 6 p21.3
retinoid X receptor, gamma
Identifiers
Symbol(s) RXRG
Entrez 6258
OMIM 180247
RefSeq NM_006917
UniProt P48443
Other data
Locus Chr. 1 q22-q23

There are three forms of retinoid X receptor (RXR), RXR-alpha, RXR-beta, and RXR-gamma. RXRs are nuclear receptors with activity similar to the steroid receptors such as estrogen or progesterone and other nuclear receptors such as PPAR, LXR and FXR. 9-cis retinoic acid is the natural ligand for RXR and like the steroid receptors, when activated, it dimerizes usually forming heterodimer, translocates to the cell nucleus, and binds to hormone response elements on DNA which elicits expression or transrepression of gene products. The RXRs are also known to act as promiscuous heterodimer partners for the non-classical steroid receptors (classical steroid receptors are androgen, estrogen, glucocorticoid, progesterone and mineralocorticoid). Hugo is a masculine name. ... The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... In biology and evolutionary computation, a locus is the position of a gene (or other significant sequence) on a chromosome. ... Chromosome 9 is one of the 23 pairs of chromosomes in humans. ... Hugo is a masculine name. ... The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... In biology and evolutionary computation, a locus is the position of a gene (or other significant sequence) on a chromosome. ... Chromosome 6 is one of the 23 pairs of chromosomes in humans. ... Hugo is a masculine name. ... The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... In biology and evolutionary computation, a locus is the position of a gene (or other significant sequence) on a chromosome. ... Chromosome 1 is, by convention, the designation for the largest human chromosome. ... Nuclear receptors are a class of intracellular receptors which function as ligand activated transcription factors which up or down regulate the expression of genes. ... Estrogens (also oestrogens) are a group of steroid compounds, named for their importance in the oestrus cycle, functioning as the primary female sex hormone. ... Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. ... In cell biology, peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor isoforms that exist across biology. ... LXR Cross Referencer, usually known as LXR, is a general purpose source code indexer and cross-referencer that provides web-based browsing of source code with links to the definition and usage of any identifier. ... The farnesoid X receptor (FXR) is a nuclear hormone receptor with activity similar to that seen in other steroid receptors such as estrogen or progesterone but more similar in form to PPAR, LXR and RXR. Its not as good as PXR. Chenodeoxycholic acid and other bile acids are the... The Retinoids are a class of chemical compounds that are related chemically to vitamin A. Retinoids are used in medicine, primarily due to the way they regulate epithelial cell growth. ... In chemistry, a ligand is an atom, ion, or molecule (see also: functional group) that generally donates one or more of its electrons through a coordinate covalent bond to, or shares its electrons through a covalent bond with, one or more central atoms or ions (these ligands act as a... In cell biology, the nucleus (from Latin nucleus or nuculeus, kernel) is found in all eukaryotic cells and contains the nuclear genes which form most of the cells genetic material. ... Hormone response elements (HRE) are located on DNA and act as receptors for steroid hormone receptor complexes. ... The general structure of a section of DNA Deoxyribonucleic acid (DNA) is a nucleic acid that contains the genetic instructions for the biological development of a cellular form of life or a virus. ... Androgen is the generic term for any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen receptors. ... Estrogens (also oestrogens) are a group of steroid compounds, named for their importance in the oestrus cycle, functioning as the primary female sex hormone. ... Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger similar effects. ... Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. ... Mineralocorticoids is a class of steroids characterised by their similarity to aldosterone and their influence on salt and water metabolism. ...


A ligand is simply a molecule with interacts with a protein, by specifically binding to the protein. RAR’s dimerize usually forming heterodimers, translocate to the cell nucleus, and bind to RAR response elements on DNA.

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See also


  Results from FactBites:
 
Retinoid X Receptor (687 words)
The retinoid X receptor (RXR) is a member of nuclear hormone receptor family proteins.
RXR is also implicated in some pathological conditions as neoplastic formation and it is a potential target for cancer therapy (2).
(1) Mangelsdorf, D.J., and Evans, R.M.(1995) The RXR heterodimers and orphan receptors.
Breast Cancer Research | Full text | A retinoid X receptor (RXR)-selective retinoid reveals that RXR-alpha is ... (5433 words)
RXR heterodimers typically bind to the 5' half of the DNA direct repeat and may also homodimerize [22].
Some of these estrogen receptor negative cell lines have been shown to be resistant to the antiproliferative effects of the RAR agonist all-trans RA The RXR ligand mediated effects were associated with inhibition of growth factor signaling and cell cycle regulatory pathways.
Combination of PPAR and RXR ligands increased transactivation of a responsive promoter in human breast cancer cell lines, which is in agreement with previous studies [14].
  More results at FactBites »

 
 

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