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Encyclopedia > Retinal pigment epithelium
Retinal pigment epithelium
Section of retina. (Pigmented layer labeled at bottom right.)
Plan of retinal neurons. (Pigmented layer labeled at bottom right.)
Latin p. pigmentosa retinae
Gray's subject #225 1016
Dorlands/Elsevier p_07/12617535

The retinal pigment epithelium is the pigmented cell layer just outside the neurosensory retina that nourishes retinal visual cells, and is firmly attached to the underlying choroid and overlying retinal visual cells.[1][2] The RPE is composed of a single layer of hexagonal cells that are densely packed with pigment granules.[1] Image File history File links Gray881. ... Human eye cross-sectional view. ... Image File history File links Gray882. ... Latin is an ancient Indo-European language originally spoken in Latium, the region immediately surrounding Rome. ... Elseviers logo. ... For animal and plant pigments, see Pigment, biology. ... Human eye cross-sectional view. ... The choroid, also known as the choroidea or choroid coat, is the vascular layer of the eye lying between the retina and the sclera. ... Drawing of the structure of cork as it appeared under the microscope to Robert Hooke from Micrographia which is the origin of the word cell. Cells in culture, stained for keratin (red) and DNA (green). ...

When viewed from the outer surface, these cells are smooth and hexagonal in shape. When seen in section, each cell consists of an outer non-pigmented part containing a large oval nucleus and an inner pigmented portion which extends as a series of straight thread-like processes between the rods, this being especially the case when the eye is exposed to light. The eukaryotic cell nucleus. ...

In the eyes of albinos, the cells of this layer contain no pigment. Wikipedia does not yet have an article with this exact name. ...

The Retinal Pigment Epithelium is involved in the phagocytosis of the outer segment of photoreceptor cells and it is also involved in the vitamin A cycle where it isomerizes all trans retinol to 11-cis Retinal.


  1. ^ a b Cassin, B. and Solomon, S. Dictionary of Eye Terminology. Gainsville, Florida: Triad Publishing Company, 1990.
  2. ^ Boyer MM, Poulsen GL, Nork TM. "Relative contributions of the neurosensory retina and retinal pigment epithelium to macular hypofluorescence." Arch Ophthalmol. 2000 Jan;118(1):27-31. PMID 10636410.

See also

Bruchs membrane is the innermost layer of the choroid. ... Drusen are tiny yellow or white fat globules and extracellular material that build up in the retina of the eye or on the optic nerve head. ...

External links

This article was originally based on an entry from a public domain edition of Gray's Anatomy. As such, some of the information contained herein may be outdated. Please edit the article if this is the case, and feel free to remove this notice when it is no longer relevant. Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. ... The public domain comprises the body of all creative works and other knowledge—writing, artwork, music, science, inventions, and others—in which no person or organization has any proprietary interest. ... An illustration from the 1918 edition Henry Grays Anatomy of the Human Body, commonly known as Grays Anatomy after Henry Gray, is an anatomy textbook widely regarded as a classic work on human anatomy. ...

  Results from FactBites:
Retinal Physician (1462 words)
Congenital hypertrophy of the RPE with halo superiorly and central depigmented lacuna.
The retinal vessels within and overlying the lesion are often stretched or tortuous and are obscured by white fibroglial tissue at the level of the vitreoretinal interface.
Adenocarcinoma arising from congenital hypertrophy of the retinal pigment epithelium.
Retinal Pigment Epithelium (RPE) Detachment (599 words)
RPE detachment is a non-specific anatomical alteration that may result from any number of choroidal disorders that disrupt the normal junction between the basement membrane of the RPE and the inner collagenous layer of Bruch’s membrane.
In cases of idiopathic RPE detachment, a striking similarity with ICSC is seen in the predisposed patient population; i.e.
RPE detachment in patients over 55 years of age should be considered secondary to choroidal neovascular membrane, rather than idiopathic, until proven otherwise.
  More results at FactBites »



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