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Encyclopedia > Reticulocyte
Reticulocyte
Reticulocyte
Erythrocyte
Erythrocyte

Reticulocytes are immature red blood cells, typically comprising about 1% of the red cells in the human body. Reticulocytes develop and mature in the red bone marrow and then circulate for about a day in the blood stream before developing into mature red blood cells. Like mature red blood cells, reticulocytes do not have a cell nucleus. They are called reticulocytes because of a reticular (mesh-like) network of ribosomal RNA that becomes visible under a microscope with certain stains. Image File history File links Polychromatic_erythrocyte. ... Image File history File links Polychromatic_erythrocyte. ... Image File history File links Erythrocyte. ... Image File history File links Erythrocyte. ... Human red blood cells Red blood cells are the most common type of blood cell and the vertebrate bodys principal means of delivering oxygen from the lungs or gills to body tissues via the blood. ... Grays Anatomy illustration of cells in bone marrow. ... The eukaryotic cell nucleus. ... Figure 1: Ribosome structure indicating small subunit (A) and large subunit (B). ... Ribonucleic acid (RNA) is a nucleic acid polymer consisting of nucleotide monomers. ...


Reticulocytes appear slightly bluer than other red cells when looked at with the normal Romanowsky stain. Reticulocytes are also slightly larger, which can be picked up as a high MCV (mean corpuscular volume) with a full blood count done by machine. Romanowsky staining was a prototypical staining technique that was the forerunner of several distinct but similar methods, including Giemsa, Wright, and Leishman stains, which are used to differentiate cells in pathologic specimens. ... The mean corpuscular volume, or MCV, is a measure of the average red blood cell volume that is reported as part of a standard complete blood count. ... A full blood count (FBC) or complete blood count (CBC) is a test requested by a doctor or other medical professional that gives information about the cells in a patients blood. ...


Reticulocyte count

The reticulocyte count is the percentage of circulating red blood cells that are in the reticulocyte stage.


To accurately measure reticulocyte counts, automated counters that use lasers mark cell samples with fluorescent dye that marks RNA and DNA. This distinguishes reticulocytes as the middle ground of dye response to laser light, between red blood cells (which have neither RNA nor DNA) and lymphocytes (which have a large amount of DNA, unlike reticulocytes).[1] Ribonucleic acid (RNA) is a nucleic acid polymer consisting of nucleotide monomers. ... The general structure of a section of DNA Deoxyribonucleic acid (DNA) is a nucleic acid that contains the genetic instructions for the biological development of a cellular form of life or a virus. ... A lymphocyte is a type of white blood cell involved in the human bodys immune system. ...


The normal range of values for reticulocytes in the blood depends on the clinical situation and the lab, but broadly speaking is 0.5% to 1.5%. The number of reticulocytes is a good indicator of red bone marrow activity, and can be used by doctors to monitor the progress of treatment for anaemia. The specimen requirement for a reticulocyte count is EDTA anti-coagulated whole blood, which is generally a lavender-top test tube. Grays Anatomy illustration of cells in bone marrow. ... EDTA is the chemical compound ethylenediaminetetraacetic acid. ...


Reticulocytes increase in number and percentage when there is increased production of red blood cells such as in a haemolytic anaemia or sickle cell anemia. The increase in reticulocytes is called reticulocytosis. Hemolysis (alternative spelling haemolysis) is the excessive breakdown of red blood cells. ... Sickle-shaped red blood cells Sickle cell anemia (American English), sickle cell anaemia (British English) or sickle cell disease is a genetic disease in which red blood cells may change shape under certain circumstances. ... A reticulocyte is an immature red blood cell that appears especially during regeneration of lost blood. ...


Abnormally low numbers of reticulocytes can be attributed to chemotherapy, aplastic anemia, pernicious anemia, bone marrow malignancies, problems of erythropoietin production, or other causes of anaemia due to poor RBC production. Chemotherapy is the use of chemical substances to treat disease. ... Aplastic anemia is a condition where the bone marrow does not produce enough, or any, new cells to replenish the blood cells. ... Pernicious anemia refers to a type of autoimmune anemia. ... Grays Anatomy illustration of cells in bone marrow. ... Erythropoietin Erythropoietin (or EPO) is a glycoprotein hormone that is a growth factor for erythrocyte (red blood cell) precursors in the bone marrow. ...


See also

A reticular cell produces reticular fibers and surrounds the fibers with its cytoplasm, which isolates the fiber from other components of the tissues or cells. ... The Reticulocyte production index is a calculation used by physicians in the diagnosis of anemia. ...

External links

 v · d · e 
Blood - Blood plasma
Pluripotential hemopoietic stem cells | Red blood cells (ReticulocyteNormoblast) | White blood cells
Lymphocytes (Lymphoblast)
T cells (CytotoxicHelperRegulatory T cellsNatural Killer T cells) | B cells (Plasma cells & Memory B cells) | Natural killer cells
Myelocytes (Myeloblast)
Granulocytes (NeutrophilEosinophilBasophil) | Mast cell precursors | Monocytes (HistiocyteMacrophagesDendritic cellsLangerhans cells, MicrogliaKupffer cellsOsteoclasts) | Megakaryoblast | Megakaryocyte | Platelets

  Results from FactBites:
 
Reticulocyte Count | Caremark Health Resources (654 words)
Reticulocytes were first described as transitional forms of red blood cells by Wilhelm H. Erb in 1865.
A low reticulocyte count indicates that the bone marrow is not producing a normal number of red blood cells.
A dye that is used to stain the blood cells for the reticulocyte count.
Reticulocyte count (778 words)
A reticulocyte count is usually performed when patients are evaluated for anemia and response to its treatment.
Reticulocytes were first described as transitional forms of red blood cells by Wilhelm H. Erb in 1865.
A low reticulocyte count indicates that the bone marrow is not producing a normal number of red blood cells.
  More results at FactBites »

 
 

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