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Encyclopedia > Research chemical
 The factual accuracy of this article is disputed.
Please see the relevant discussion on the talk page.

:This article covers research chemicals in the bogus sense that the term was used by internet chemical suppliers who hoped by selling drugs as "chemicals for research" (with disclaimers that they were "poisonous non-consumables" rather than drugs) that they would evade the intent clause of the US controlled substance analogue laws. This was shown to have no validity in 2001 when JLF was arrested and then 2004 when multiple sellers were arrested by the DEA in Operation Web Tryp. No chemist would ever define "research chemical" in this way, nor would any pharmacologist consider "research chemical" a valid description for these drugs. These are properly called experimental or designer drugs. This article should not exist, and should be replaced with an article that describes research chemicals in the sense that chemists and pretty much everybody else in the world would understand. Wikipedia does not have an article with this exact name. ... The Federal Analog Act is a controversial section of the DEA Controlled Substances Act, allowing any chemical substantially similar to an illegal drug (one in Schedule I or II) to be treated as if it were also in Schedule I, but only if it is intended for human consumption. ... DEA is an abbreviation of the following, among others: Data Encryption Algorithm Dance Educators of America (USA) Davis Education Association (USA) Deutsche Erdöl-Aktiengesellschaft (Germany) Diplôme détudes approfondies, a former French graduate degree Directorate of Environmental Affairs (Namibia) Disposable email address Drug Enforcement Administration (USA) Diethanol Amine... Operation Web Tryp was a United States Drug Enforcement Administration operation that ended on July 21, 2004, with the arrests of 10 persons. ... Designer drug is a term to used to describe psychoactive drugs which are created (or marketed, if they had already existed) to get around existing drug laws by modifying their molecular structures to varying degrees. ...



Research chemical is a term to used euphemistically to describe newer, quasi-legal psychoactive drugs. The term is typically used by the suppliers of substances which, although not prohibited by any law, are likely to attract the attention of law-enforcement agencies, who will attempt to prevent their sale and punish the supplier. The use of a descriptive term that cannot be connoted as encouraging human consumption is apparently intended to minimise the legal risk to the supplier. A euphemism is an expression intended by the speaker to be less offensive, disturbing, or troubling to the listener than the word or phrase it replaces. ... A psychoactive drug or psychotropic substance is a chemical that alters brain function, resulting in temporary changes in perception, mood, consciousness, or behaviour. ... Many drugs are provided in tablet form. ...


Many substances sold as "research chemicals" are hallucinogens and bear a chemical resemblance to common illegal drugs such as psilocybin and mescaline. As with other hallucinogens, these substances are often taken for the purposes of facilitating spiritual processes (see entheogen), mental reflection (see psychedelic) or recreation. Some research chemicals on the market are not psychoactive, but can be used as precursors in the synthesis of other potentially psychoactive substances. Both classes of research chemical present difficulties for legislators, owing to the very large variety of possible structural modifications that can be made to a scheduled psychoactive substance to produce new psychoactives that are yet to be scheduled. Extensive surveys of structural variations have been conducted by pharmaceutical corporations, universities and independent researchers over the last century, from which some of the presently available research chemicals derive. One researcher of particular fame or notoriety (depending on your viewpoint) is Dr. Alexander Shulgin, who presented syntheses and phamarmacological explorations of hundreds of substances in the books TiHKAL and PiHKAL (co-authored with Ann Shulgin), and has served as an expert witness for the defense in several court cases against manufacturers of psychoactive drugs. Hallucinogenic drug - drugs that can alter sensory perceptions. ... Psilocybin (4-phosphoryloxy-N, N-dimethyltryptamine) is a psychedelic alkaloid of the tryptamine family. ... Mescaline or 3,4,5-trimethoxyphenethylamine is a psychedelic hallucinogenic drug and entheogen of the phenethylamine family. ... See: Spirituality Spiritual music Spiritual dance The Age of Spiritual Machines Spiritual possession This is a disambiguation page, a list of pages that otherwise might share the same title. ... The word entheogen is a modern term derived from two Ancient Greek words, ενθεος (entheos) and γενεσθαι (genesthai). ... The word psychedelic is a neologism coined from the Greek words for mind, ψυχη (psyche), and manifest, δηλειν (delein). ... Recreational drug use is the use of psychoactive drugs for recreational rather than medical or spiritual purposes, although the distinction is not always clear. ... // General In generic terms, a precursor is something that existed before and was incorporated into something that came later. ... In chemistry, the phrase chemical synthesis appears to have one of two meanings. ... Alexander Sasha Shulgin (born June 17, 1925) is a pharmacologist, chemist and drug developer. ... In chemistry, the phrase chemical synthesis appears to have one of two meanings. ... Pharmacology (in Greek: pharmacon (φάρμακον) is drug, and logos (λόγος) is science) is the study of how chemical substances interact with living systems. ... TiHKAL is a 1997 book written by Dr Alexander Shulgin and Ann Shulgin about tryptamines. ... PiHKAL is a 1991 book written by Dr. Alexander Shulgin and Ann Shulgin about phenethylamines. ... Ann Shulgin (born March 22, 1931) is an author and wife of famous chemist Alexander Shulgin. ...


Most chemical suppliers sell research chemicals in bulk form as powder, not as pills. Active dosages are often in the low milligram range, and thus it is critical for the end user to weigh doses with a precision scale, instead of guessing ("eyeballing"). When a chemical increases in popularity, it will often be sold in pill form to reach a wider market. Some of the most popular chemicals are also given street names (like "Foxy" or "Foxy Methoxy" for 5-MeO-DiPT). Once a chemical reaches this kind of popularity, it is usually just a matter of time before it is added to the list of scheduled (prohibited) drugs. 5-MeO-DiPT is a tryptamine also known as Foxy Methoxy or just foxy due to its supposed aphrodisiac-like effects, although it is primarily used recreationally as a psychedelic. ...

Contents


Safety and law

Little if any research has been done on the toxicology or pharmacology of most of these drugs. Few, if any, human or animal studies have been done. Unlike better known drugs like marijuana, which has been used by billions of people worldwide, research chemicals are new and may only have been used by a few dozen people for a few months. The safety of research chemicals is untested and due to the recent development of many of them, laws banning or restricting their use have not been developed yet. However, many of the chemicals fall under the various drug analouge legislations in different countries. Toxicology (from the Greek words toxicon and logos) is the study of the adverse effects of chemicals on living organisms. ... Pharmacology (in Greek: pharmacon (φάρμακον) is drug, and logos (λόγος) is science) is the study of how chemical substances interact with living systems. ... Filmed by PETA, Covance primate-testing lab, Vienna, Virginia, 2004-5. ... Cannabis is a plant also known as Cannabis sativa, hemp, or marijuana. ...


In 2004, the US Drug Enforcement Administration raided and shut down several internet based research chemical vendors in an operation called Operation Web Tryp. With help from the authorities in India and China, two chemical manufacturers were also closed. Many other internet based vendors promptly stopped doing business, even though their products are still not explicitly illegal. Since 1973, the DEA has enforced the drug laws in the United States. ... Operation Web Tryp was a United States Drug Enforcement Administration operation that ended on July 21, 2004, with the arrests of 10 persons. ...


Common research chemicals

Most research chemicals are structural analogues of tryptamines or phenethylamines, but there are also completely unrelated chemicals which are normally considered to be part of the group. It is impossible to determine psychoactivity or other pharmaceutical properties of these chemicals strictly from examining their structure, and many of the substances have common effects whilst structurally different and vice versa. Confusing nomenclature, similar names, and differing naming schemes can all lead to (and is anecdotally known to have led to) potentially hazardous mixups for end users. Tryptamine (3-(2-aminoethyl)indole) is a monoamine compound that is widespread in nature. ... Phenethylamine is an alkaloid and monoamine. ...

  • Some common tryptamine-based research chemicals:
    • 4-Acetoxy-DIPT, n,n-diisopropyl-4-acetoxytryptamine
    • 4-HO-DIPT, 4-hydroxy-n,n-diisopropyltryptamine
    • 5-MeO-AMT, 5-methoxy-a-methyltryptamine
    • 5-MeO-DET, 5-methoxy-n,n-diethyltryptamine
    • 5-MeO-DIPT, 5-methoxy-di-isopropyl-tryptamine (also known as "Foxy" or "Foxy Methoxy")
    • 5-MeO-MIPT, isopropy-n-methyl-5-methoxyltryptamine
    • AMT, alpha-methyltryptamine
    • DIPT, di-isopropyl-tryptamine
    • DPT, n,n-dipropyltryptamine
  • Some common phenethylamine-based research chemicals:
    • 2C-B, 4-bromo-2,5-dimethoxyphenethylamine (also known as "bromo-mescaline")
    • 2C-C, 2,5-dimethyoxy-4-chlorophenethylamine
    • 2C-I, 2,5-dimethoxy-4-iodophenethylamine
    • 2C-E, 2,5-dimethoxy-4-ethyl-phenethylamine
    • 2C-H, 2,5-dimethoxyphenethylamine
    • 2C-T-2, 2,5-dimethoxy-4-ethylthiophenethylamine
    • 2C-T-4, 2,5-dimethoxy-4(i)-propylthiophenethylamine
    • 2C-T-7, 2,5-dimethoxy-4-(n)-propylthiophenethylamine
    • 2C-T-21, 2,5-dimethoxy-4-(2-fluoroethylthio)phenethylamine

Tryptamine (3-(2-aminoethyl)indole) is a monoamine compound that is widespread in nature. ... 4-Acetoxy-DIPT (4-acetoxy-N,N-diisopropyltryptamine) is a hallucinogenic tryptamine. ... Chemical structure of 4-HO-DIPT 4-HO-DiPT (also known as 4-hydroxy-di-isopropyl-tryptamine, or Iprocin) is a hallucinogenic drug. ... 5-MeO-AMT is an entheogenic drug soluble in alcohol. ... 5-MeO-DET (5-methoxy-N,N-diethyltryptamine) is a hallucinogenic tryptamine. ... 5-MeO-DiPT is a tryptamine also known as Foxy Methoxy or just foxy due to its supposed aphrodisiac-like effects, although it is primarily used recreationally as a psychedelic. ... 5-MeO-MIPT (5-methoxy-N-methyl-N-isopropyltryptamine) is a hallucinogenic tryptamine. ... α-methyl-tryptamine, also known as AMT or IT-290, is a synthetic drug of the tryptamine family. ... DIPT or diisopropyltryptamine is a psychedelic hallucinogenic drug of the tryptamine family that has a unique effect. ... Dipropyltryptamine (DPT) is a psychedelic and entheogenic hallucinogenic drug belonging to the tryptamine family. ... Phenethylamine is an alkaloid and monoamine. ... 2C-B is a psychedelic hallucinogenic drug first synthesized by Alexander Shulgin in 1974, sometimes used as an entheogen. ... 2C-C is a psychedelic hallucinogenic drug first synthesized by Alexander Shulgin, sometimes used as an entheogen. ... 2C-I is a psychedelic hallucinogenic drug and phenethylamine that was developed and popularized by Alexander Shulgin, sometimes used as an entheogen. ... 2C-E (2,5-dimethoxy-4-ethylphenethylamine) is a psychedelic hallucinogenic drug phenethylamine first synthesized by Alexander Shulgin, sometimes used as an entheogen. ... 2C-T-2, also known as Rosy, is a psychedelic entheogen presumably first synthesized in 1981 by Alexander Shulgin, and has structural and pharmacodynamic properties similar to the drugs Mescaline, MDMA, and 2C-B. In Shulgins book PIHKAL (Phenethylamines I Have Known and Loved), the dosage range is listed... 2C-T-4 or 2,5-dimethoxy-4-(i)-propylthiophenethylamine is a psychedelic entheogen presumably first synthesized by Alexander Shulgin that has some structural and pharmacodynamic properties similar to the drug MDMA, and even more similarities with the drugs mescaline, 2C-B, and 2C-T-7. ... 2C-T-7 (Sulfurous Samadhi) is a psychedelic phenethylamine presumably first synthesized in 1986 by Alexander Shulgin, sometimes used as an entheogen; it has structural and pharmacodynamic properties similar to the drugs Mescaline, MDMA, and 2C-B. In Shulgins book PiHKAL (Phenethylamines I Have Known and Loved), the dosage... 2C-T-21 is a psychedelic phenethylamine first synthesized by Alexander Shulgin, sometimes used as an entheogen. ...

See Also

  • Erowid
  • JLF (famous research chemical supply company)
  • RAC_Research (know closed and currently being prosecuted research chemical comapny)

Erowid. ... JLF Primary Materials, formerly known as JLF Poisonous Non Consumables, was a popular internet website during the last part of the 20th century which sold research chemicals - essentially new hallucinogenic, stimulant, and other drug analogues which had not as yet been made illegal. ... RAC was a research chemical supplier. ...

External links

  • Research Chemical FAQ on Erowid

  Results from FactBites:
 
EPA / NHEERL / Aquatic Stressors / Toxic Chemicals Research (663 words)
To meet this challenge, research is planned to evaluate the utility of using surrogate species to estimate the effects of toxic chemicals and to develop models that will facilitate extrapolation from one species or taxonomic group to another.
Research in under this topic will describe and demonstrate a framework that will facilitate a more accurate determination of where and to what extent loadings of persistent bioaccumulative toxicants (PBTs) pose unacceptable ecological risks to aquatic ecosystems.
A variety of research is planned, including work to characterize the spatial and temporal distribution of stressors within a given landscape, development of stressor-response relationships for endpoints such as survival and fecundity, and an exploration of ways to extrapolate between species and to take population dynamics and life-stages into account.
Erowid Psychoactive Vaults : Research Chemicals (291 words)
Chemicals marked on Erowid by our Research Chemical Symbol should be considered experimental chemicals.
Although some people are willing to ingest these chemicals for their effects, it is not reasonable to assume that these chemicals are in any way 'safe' to use recreationally.
Although all psychoactive use involves risk, this class of chemicals has undergone virtually no human or animal toxicity studies and there is little to no data on possible long term problems, addiction potential, allergic reactions, or acute overdoses.
  More results at FactBites »

 
 

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