Radial glial cells are a pivotal cell type in the developing CNS involved in key developmental processes, ranging from patterning and neuronal migration to their newly described role as precursors during neurogenesis. The term 'radial glial cell' refers to their two major characteristics, their long radial processes extending from the ventricular zone (VZ) to the pial surface and their glial properties, such as the content of glycogen granules or the expression of the astrocyte-specific glutamate transporter or the glial fibrillary acidic protein (GFAP). Notably, recent evidence demonstrates that radial glial cells characterized by long radial processes and astroglial properties constitute the majority of precursors during neurogenesis. Indeed, all radial glial cells divide throughout neurogenesis and give rise to the majority of projection neurons in the cerebral cortex. Neurogenesis (birth of neurons) is the process by which neurons are created. ... The pia mater (Latin: tender mother, itself a translation from Arabic) is the delicate innermost layer of the meninges - the membranes surrounding the brain and spinal cord. ... Neuroglia cells of the brain shown by Golgis method. ... Electron micrograph of a section of a liver cell showing glycogen deposits as accumulations of electron dense particles (arrows). ... Astrocytes, also known as astroglia, are characteristic star-shaped glial cells in the brain. ... Glutamate is the anion of glutamic acid. ... Intermediate filaments are one component of the cytoskeleton - important structural components of living cells. ... Neurogenesis (birth of neurons) is the process by which neurons are created. ... Location of the cerebral cortex Slice of the cerebral cortex, ca. ...
Hartfuss E, Forster E, Bock HH, Hack MA, Leprince P, Luque JM, Herz J, Frotscher M, Gotz M. (2003) Reelin signaling directly affects radial glia morphology and biochemical maturation. Development 130(19):4597-609. PMID 12925587
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