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Encyclopedia > Pyridoxine
Pyridoxine
Pyridoxine
Common name pyridoxine
Systematic name 4,5-bis(hydroxymethyl)-
2-methylpyridin-3-ol
Other names 5-hydroxy-6-methyl-
3,4-pyridinedimethanol
Chemical formula C8H11NO3
Molecular mass 169.18 g/mol
Density x.xxx g/cm3
Melting point 159-162 °C
Boiling point xx.x °C
CAS number [65-23-6]
SMILES xxxx
Disclaimer and references
Main article: vitamin B6

Pyridoxine is one of the compounds that can be called vitamin B6, along with Pyridoxal and Pyridoxamine. It differs from pyridoxamine by the substituent at the '4' position. It is often used as 'pyridoxine hydrochloride'. Image File history File links This is a lossless scalable vector image. ... In science, a common name is any name by which a species or other concept is known that is not the official scientific name. ... There are millions of possible objects that can be described in science, too many to create common names for every one. ... This article does not cite its references or sources. ... The molecular mass (abbreviated MM) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In physics, density is mass m per unit volume V. For the common case of a homogeneous substance, it is expressed as: where, in SI units: ρ (rho) is the density of the substance, measured in kg·m-3 m is the mass of the substance, measured in kg V is... The melting point of a crystalline solid is the temperature at which it changes state from solid to liquid. ... The boiling point of a substance is the temperature at which it can change its state from a liquid to a gas throughout the bulk of the liquid at a given pressure. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The simplified molecular input line entry specification or SMILES is a specification for unambiguously describing the structure of chemical molecules using short ASCII strings. ... Pyridoxine Vitamin B6 pyridoxine is a water-soluble vitamin. ... Pyridoxine Vitamin B6 pyridoxine is a water-soluble vitamin. ... Pyridoxal is one of the three natural organic compounds, along with pyridoxamine and pyridoxine, that comprise vitamin B6. ... The two major forms of vitamin B6 are pyridoxine and pyridoxamine. ... The two major forms of vitamin B6 are pyridoxine and pyridoxamine. ...

Contents

Chemistry

It is based on a pyridine ring, with hydroxyl, methyl, and hydroxymethyl substituents. It is converted to the biologically active form pyridoxal 5-phosphate. Pyridine is a chemical compound with the formula C5H5N. It is a liquid with a distinctively putrid odour. ... // Hydroxyl group The term hydroxyl group is used to describe the functional group -OH when it is a substituent in an organic compound. ... In chemistry a methyl-group is a hydrophobic Alkyl functional group which is derived from methane (CH4). ... In organic chemistry, a substituent is an atom or group of atoms substituted in place of a hydrogen atom on the parent chain of a hydrocarbon. ... This article or section does not cite its references or sources. ...


Function in the body

Pyridoxine assists in the balancing of sodium and potassium as well as promoting red blood cell production. It is linked to cardiovascular health by decreasing the formation of homocysteine. It has been suggested that Pyridoxine might help children with learning difficulties, and may also prevent dandruff, eczema, and psoriasis.[citation needed] In addition, pyridoxine can help balance hormonal changes in women and aid in immune system. Lack of pyridoxine may cause anemia, nerve damage, seizures, skin problems, and sores in the mouth.[citation needed] Homocysteine is a chemical compound with the formula HSCH2CH2CH(NH2)CO2H. It is a homologue of the naturally-occurring amino acid cysteine, differing in that its side-chain contains an additional methylene (-CH2-) group before the thiol (-SH) group. ...


It is required for the production of the monoamine neurotransmitters serotonin, dopamine, noradrenaline and adrenaline as it is the cofactor for the enzyme aromatic amino acid decarboxylase. This enzyme is responsible for converting the precusors 5-hydroxytryptophan (5-htp) into serotonin and 3,4-dihydroxyphenylalanine (l-dopa) into dopamine, noradrenaline and adrenaline. As such it has been implicated in the treatment of depression and anxiety.[citation needed] In biochemistry, monoamines are a group of organic compounds containing only one amino group. ... Chemical structure of D-Aspartic Acid, a common Amino Acid neurotransmitter. ... Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesized in serotonergic neurons in the central nervous system (CNS) and enterochromaffin cells in the gastrointestinal tract of animals including humans. ... Dopamine is a phenethylamine naturally produced by the human body. ... Norepinephrine, known as noradrenaline outside the USA, is a catecholamine and a phenethylamine with chemical formula C8H11NO3. ... Epinephrine (INN) or adrenaline (BAN) is a hormone and a neurotransmitter. ... Aromatic L-amino acid decarboxylase (EC 4. ... 5-HTP (5-Hydroxy-tryptophan) is decarboxylated to the neurotransmitter serotonin (5-HT) by the enzyme aromatic-L-amino-acid decarboxylase. ... // Therapeutic use L-DOPA is used to replace dopamine lost in Parkinsons disease because dopamine itself cannot cross the blood-brain barrierwhere its precursor can. ... Clinical depression (also called major depressive disorder, or unipolar depression when compared to bipolar disorder) is a state of intense sadness, melancholia or despair that has advanced to the point of being disruptive to an individuals social functioning and/or activities of daily living. ... This article includes a list of works cited or a list of external links, but its sources remain unclear because it lacks in-text citations. ...


A very good source of Pyridoxine is dragon fruit from South East Asia Pitaya fruits Pitaya fruit Pitaya inside The pitaya, also known as dragonfruit or dragon pearl is the fruit of a pitaya cactus. ... Location of Southeast Asia Southeast Asia is a subregion of Asia. ...


Medicinal uses

It is given to patients taking Isoniazid to combat the toxic side effects of the drug. Pyridoxine is given 10-50 mg/day to patients on INH (Isoniazid) to prevent Peripheral neuropathy and CNS effects that are associated with the use of isoniazid. Template:Compounding Isoniazid (also called isonicotinyl hydrazine or isonicotinic acid hydrazide); abbreviated INH or just H. Isoniazid is a first-line antituberculous medication used in the prevention and treatment of tuberculosis. ... Peripheral neuropathy is the term for damage to nerves of the peripheral nervous system, which may be caused either by diseases of the nerve or from the side-effects of systemic illness. ... CNS can refer to: in air traffic control, Communication, Navigation, Surveillance often associated with the acronym ATM (Air Traffic Management) as CNS/ATM. the central nervous system the title granted to a Clinical Nurse Specialist the mnemonic for the demogroup Conspiracy the IATA code for Cairns International Airport This is...


Vitamin B6 can be compounded into a variety of different dosage forms. It can be used orally as a tablet, capsule, or solution. It can also be used as a nasal spray or for injection when in its solution form. The following is a procedure for producing a diluting solution of vitamin B6, taken from the USP/NF.


"Diluting Solution: Dissolve 25g of edentate disodium in 1000mL of water and mix. Dissolve an accurately weighed quantity of USP Pyridoxine Hydrochloride RS in Diluting Solution, and dilute quantitatively, and stepwise if necessary, with Diluting Solution to obtain a Solution having a known concentration of about 0.024mg/mL."


Source: Council of Experts. USP/NF. 2006 Ed. Rockville, MD: The United States Pharmacopeial Convention; 2005.


External links

  • Links to external chemical sources

  Results from FactBites:
 
Olympus MIC-D: Polarized Light Gallery - Pyridoxine (Vitamin B-6) (339 words)
As one of the central vitamins in the B-complex, pyridoxine (better known as vitamin B-6) is a water-soluble nutrient that is vital as a precursor to a coenzyme involved in transaminations, decarboxylations, racemizations, and numerous modifications to amino acid side chains.
Pyridoxine was discovered in the 1930s as the result of a series of nutritional investigations of rats fed vitamin-free diets.
Commercially synthesized in a hydrochloride formulation, pyridoxine is known to organic chemists as 3,4-pyridinedimethanol, 5-hydroxy-6-methyl hydrochloride or pyridoxol hydrochloride.
Vitamin B6 - pyridoxine information page. All about vitamin B6 (also known as pyridoxine) and the role it plays in your ... (731 words)
Pyridoxine is required for the balancing of hormonal changes in women as well as assisting the immune system and the growth of new cells.
Pyridoxine might also be of benefit for children with learning difficulties, as well as assisting in the prevention of dandruff, eczema and psoriasis.
Pyridoxine should be taken together with the entire B group vitamins, and in supplementation the quantity of B6 should be nearly the same as B2, as the B 2 is needed to activate the Pyridoxine.
  More results at FactBites »

 
 

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