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Encyclopedia > Protein S

Protein S is a vitamin K-dependent plasma glycoprotein synthesized in the liver and it functions as a cofactor to Protein C in the inactivation of Factors Va and VIIIa.


In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b. Only the free form has cofactor activity.


The gene (PROS1) is located on the third chromosome (3p11.1-q11.2).


Protein S deficiency is a rare blood disorder which can lead to an increased risk of thrombosis.


External link

  • OMIM 176880 (http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176880)

  Results from FactBites:
 
Protein S Information on Healthline (458 words)
and protein S are involved in regulation of blood clotting.
Protein C and protein S are decreased by some anticoagulants (Coumadin or warfarin).
During a clot-related event like a pulmonary embolism, proteins C and S are reduced anyway, and their measurements may be misleading until the episode is resolved.
Protein C and Protein S: The Test (972 words)
Protein C and Protein S tests are ordered when a person has had a thrombotic episode or thromboembolism, especially when the affected patient is relatively young (less than 50 years old) and/or does not have any other obvious reasons for developing a blood clot.
Protein C and Protein S tests should not, however, be ordered for at least 10 days after the episode, and they should not be ordered while a person is on anticoagulant therapy.
Protein C and Protein S concentrations (quantity) may be measured with, or after, function/activity levels to determine whether a sufficient amount of each is being produced, to determine the severity of any deficiencies, and to classify the type of deficiency.
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