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Encyclopedia > Propoxyphene

Dextropropoxyphene is an analgesic in the opioid category that is used to treat severe pain and severe coughs. It can be used to ease pain before, during and after an operation. It is also sometimes known as: Distalgesic or Doloxene.


Opioids work by mimicing naturally painkillers such as endorphins that bind to opioid receptors in the brain and block pain signals.


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Pharmacy Times: Balacet 325 (propoxyphene napsylate 100 mg and acetaminophen 325 mg) (423 words)
Balacet 325 (propoxyphene napsylate 100 mg and acetaminophen 325 mg)
Propoxyphene and acetaminophen are familiar drugs to the medical community, and their use—both together and alone—has been tested and marketed by various manufacturers for years.
The bioavailability of 65 mg of propoxyphene hydrochloride is approximately equivalent to 100 mg of propoxyphene napsylate.
UNODC - Bulletin on Narcotics - 1960 Issue 1 - 002 (3918 words)
The figure compares the intensity of abstinence when propoxyphene was substituted orally for morphine with that observed when a placebo was substituted, and with that observed when the regular dose of morphine was continued.
When propoxyphene was administered in doses of 400 mg every four hours, the intensity of abstinence was significantly reduced, beginning at the 14th hour and continuing through the 24th hour.
Propoxyphene was administered orally in capsules, and the total daily dose was distributed in three approximately equal doses.
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