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Encyclopedia > Procaine
Chemical structure of Procaine
Procaine
Systematic (IUPAC) name
2-(diethylamino)ethyl 4-aminobenzoate
Identifiers
CAS number 59-46-1
ATC code N01BA02 C05AD05 S01HA05
PubChem 4914
DrugBank APRD00650
Chemical data
Formula C13H20N2O2 
Mol. mass 236.31 g/mol
Pharmacokinetic data
Bioavailability n/a
Metabolism Hydrolysis by plasma esterases
Half life 40–84 seconds
Excretion Renal
Therapeutic considerations
Pregnancy cat.

B2(AU) C(US) Image File history File links Wiki_letter_w. ... Procaine structure This image is ineligible for copyright and therefore in the public domain, because it consists entirely of information that is common property and contains no original authorship. ... IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules. ... The DrugBank database available at the University of Alberta is a unique bioinformatics and cheminformatics resource that combines detailed drug (i. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... General Name, Symbol, Number carbon, C, 6 Chemical series nonmetals Group, Period, Block 14, 2, p Appearance black (graphite) colorless (diamond) Standard atomic weight 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number nitrogen, N, 7 Chemical series nonmetals Group, Period, Block 15, 2, p Appearance colorless gas Standard atomic weight 14. ... General Name, Symbol, Number oxygen, O, 8 Chemical series nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Standard atomic weight 15. ... The molecular mass (abbreviated MM) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... Hydrolysis is a chemical reaction or process in which a chemical compound reacts with water. ... It has been suggested that Effective half-life be merged into this article or section. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... It has been suggested that Renal anomalies and Renal plasma threshold be merged into this article or section. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ... Anthem: Advance Australia Fair Royal anthem: God Save the Queen Capital Canberra Largest city Sydney Official languages English (de facto 1) Government Constitutional monarchy (federal)  -  Queen Elizabeth II  -  Governor-General Michael Jeffery  -  Prime Minister John Howard Independence from the UK   -  Constitution 1 January 1901   -  Statute of Westminster 11 December 1931... Motto: (Out Of Many, One) (traditional) In God We Trust (1956 to date) Anthem: The Star-Spangled Banner Capital Washington D.C. Largest city New York City None at federal level (English de facto) Government Federal constitutional republic  - President George Walker Bush (R)  - Vice President Dick Cheney (R) Independence from...

Legal status

Prescription Only (S4)(AU) The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... The Standard for the Uniform Scheduling of Drugs and Poisons, abbreviated SUSDP, is a document used in the regulation of drugs and poisons in Australia. ... Anthem: Advance Australia Fair Royal anthem: God Save the Queen Capital Canberra Largest city Sydney Official languages English (de facto 1) Government Constitutional monarchy (federal)  -  Queen Elizabeth II  -  Governor-General Michael Jeffery  -  Prime Minister John Howard Independence from the UK   -  Constitution 1 January 1901   -  Statute of Westminster 11 December 1931...

Routes Parenteral

Procaine is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and is also used in dentistry. Owing to the ubiquity of the trade name Novocain, procaine is sometimes referred to generically as novocaine or novacaine. In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... A local anesthetic is a drug that reversibly inhibits the propagation of signals along nerves. ... In chemistry, especially in organic chemistry and biochemistry, an amino group is an ammonia-like functional group. ... General formula of a carboxylate ester. ... Intramuscular injection is the injection of a substance directly into a muscle. ... Penicillin nucleus Penicillin (sometimes abbreviated PCN) refers to a group of β-lactam antibiotics used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. ... A Dentist and Dental Assistant perform surgery on a patient. ... A trade name, also known as a trading name or a business name, is the legal name of a business, or the name which a business trades under for commercial purposes. ...


Procaine was first synthesized in 1905, and was the first injectable man-made local anesthetic used. It was created by the German chemist Albert Einhorn (1857–1917) who gave the chemical the trade name Novocaine, from the Latin Novus (meaning New) and caine, a common ending for alkaloids used as anesthetics. It was introduced into medical use by surgeon Heinrich Braun (1862–1934). Alfred Einhorn (1856 – 1917) was a German chemist most notable for first synthesizing procaine in 1905 which he patented under the name Novocain. ... Latin is an ancient Indo-European language originally spoken in Latium, the region immediately surrounding Rome. ...


Procaine is used less frequently today since more effective (and hypoallergenic) alternatives such as lidocaine (xylocaine) exist. Prior to the discovery of procaine, cocaine was the most commonly used local anesthetic. Procaine (like cocaine) has the advantage of constricting blood vessels, which reduces bleeding, unlike other local anesthetics like lidocaine, and without the euphoric and addictive qualities of cocaine. Look up hypoallergenic in Wiktionary, the free dictionary. ... Lidocaine (INN) (IPA: ) or lignocaine (former BAN) (IPA: ) is a common local anesthetic and antiarrhythmic drug. ... Cocaine (see also: crack) is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. ... Lidocaine (INN) (IPA: ) or lignocaine (former BAN) (IPA: ) is a common local anesthetic and antiarrhythmic drug. ...


Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which is then excreted by the kidneys into the urine. Allergic reactions to procaine are usually not in response to procaine itself, but to PABA. About 1 in 3000 people have an atypical form of pseudocholinesterase, which doesn't hydrolyze ester anesthetics such as procaine, resulting in a prolonged period of high levels of the anesthetic in the blood and increased toxicity. General formula of a carboxylate ester. ... Categories: Biochemistry stubs | EC 3. ... Hydrolysis is a chemical reaction or process in which a chemical compound reacts with water. ... 4-Aminobenzoic acid (also known as para-aminobenzoic acid or PABA) is an organic compound with the molecular formula C7H7NO2. ... It has been suggested that Renal anomalies and Renal plasma threshold be merged into this article or section. ... This article or section is in need of attention from an expert on the subject. ... Hydrolysis is a chemical process in which a molecule is cleaved into two parts by the addition of a molecule of water. ...


Procaine is the primary ingredient in the controversial preparation Gerovital H3, which is claimed by its advocates to remedy many effects of aging. The mainstream medical view is that these claims were seriously studied and discredited in the 1960s. Gerovital H3 is a controversial preparation, developed during the 1950s in Romania by Dr. Ana Aslan (1896?–May 20, 1988) It was and is promoted by its advocates as an effective anti-aging treatment. ...


External links

  • Links to external chemical sources

  Results from FactBites:
 
procaine Side Effects, Interactions and Information - Drugs.com (894 words)
Procaine is used as an injection during surgery and other medical and dental procedures.
You may not be able to use procaine, or you may require a dosage adjustment or special monitoring during treatment.
Procaine is administered as an injection in a hospital or clinic setting.
Procaine (252 words)
Procaine hydrochloride is a local anesthetic used primarily in dentistry.
Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-aminobenzoic acid (PABA), which is then excreted by the kidneys into the urine.
A controversial topic is the use of procaine together with hematoporphyrin in the anti-aging preparation Gerovital H3.
  More results at FactBites »

 
 

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