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Encyclopedia > Polymyositis

{{ }} Polymyositis is a type of inflammatory myopathy, related to dermatomyositis and inclusion body myositis. Polymyositis means 'many muscle inflammation'. Inflammation is the first response of the immune system to infection or irritation and may be referred to as the innate cascade. ... In medicine, a myopathy is a neuromuscular disease in which the muscle fibers dysfunction for any one of many reasons, resulting in muscular weakness. ... X-Ray of the knee in a patient with dermatomyositis. ... Inclusion body myositis (IBM) is an inflammatory muscle disease, characterized by slowly progressive wasting and weakness of the arms and legs. ...

Polymyositis tends to become evident in adulthood, presenting with bilateral proximal muscle weakness, often noted in the upper legs due to early fatigue while walking. Sometimes the weakness presents itself by the person being unable to rise from a seated position without help, or inability to raise their arms above their head. The weakness is generally progressive, accompanied by lymphocytic inflammation (mainly cytotoxic T8 lymphocytes). The cause is unknown, but seems to be related to autoimmune factors, genetics, and perhaps viruses. In rare cases, the cause is known to be infectious, associated with the pathogens that cause Lyme disease, toxoplasmosis, and others. Fatigue may refer to: Fatigue (physical) - tiredness in humans Fatigue (material) - failure by repeated stress in materials Fatigues (uniform) - military uniform (BDU or ACU) Chronic Fatigue Syndrome - a medical condition Battle fatigue - also known as Post-traumatic stress disorder Readers fatigue - a side-effect of parsing poorly formatted textual... A lymphocyte is a type of white blood cell involved in the human bodys immune system. ... Genetics (from the Greek genno γεννώ= give birth) is the science of genes, heredity, and the variation of organisms. ... A common alternate meaning of virus is computer virus. ... A pathogen or infectious agent is a biological agent that causes disease or illness to its host. ... Wikispecies has information related to: Borrelia Lyme disease or Lyme borreliosis is the most common tick-borne disease in the United States and Europe, and one of the fastest growing infectious diseases in the United States. ...

Polymyositis, like dermatomyositis, strikes females with greater frequency than males. The skin involvement of dermatomyositis is absent in polymyositis.

Diagnosis is fourfold, including elevation of creatine kinase, signs and symptoms, electromyograph (EMG) alteration, and a positive muscle biopsy. Treatment generally involves glucocorticoids, especially prednisone. At present, a number of studies are underway to determine whether patients diagnosed with polymyositis will benefit from newer drugs inhibiting the biologic effects of TNF alpha, such as Infliximab ("Remicade"). Diagnosis (from the Greek words dia = by and gnosis = knowledge) is the process of identifying a disease by its signs, symptoms and results of various diagnostic procedures. ... Creatine Kinase Creatine kinase (CK), also known as phosphocreatine kinase or creatine phosphokinase (CPK) is an enzyme (EC 2. ... In medicine, a sign is a feature of disease as detected by the doctor. ... The term symptom (from the Greek syn = con/plus and pipto = fall, together meaning co-exist) has two similar meanings in the context of physical and mental health: Strictly, a symptom is a sensation or change in health function experienced by a patient. ... Electromyography (EMG) is a medical technique for measuring muscle response to nervous stimulation. ... A biopsy (in Greek: bios = life and opsy = look/appearance) is a medical test involving the removal of cells or tissues for examination. ... The name glucocorticoid derives from early observations that these hormones were involved in glucose metabolism. ... Prednisone is a synthetic corticosteroid drug which is usually taken orally and can be used for a large number of different conditions. ...

Sporadic inclusion body myositis (sIBM): IBM is often confused with (misdiagnosed as) polymyositis and polymyositis that does not respond to treatment is likely IBM. sIBM comes on over months to years, polymyositis comes on over weeks to months. It appears that sIBM and polymyositis share some common features, especially the initial sequence of immune system activation, however, polmyositis does not display the subsequent muscle degeneration and protein abnormalities as seen in IBM. As well, polymyositis tends to respond well to treatments, IBM does not. IBM and polymyositis apparently involve different disease mechanisms than are seen in dermatomyositis. Inclusion body myositis (IBM) is an inflammatory muscle disease, characterized by slowly progressive wasting and weakness of the arms and legs. ... X-Ray of the knee in a patient with dermatomyositis. ...

  Results from FactBites:
Polymyositis (3100 words)
Polymyositis is an inflammatory disease of skeletal muscle of unknown etiology, characterized by symmetric weakness of the limb girdles, neck, and pharynx.
Dysphagia in polymyositis is primarily due to weakness of the striated musculature of the posterior pharynx.
Polymyositis is but one of a variety of diseases that may be present as muscle weakness with or without muscle pain.
Diagnose-Me: Condition: Polymyositis (2502 words)
Polymyositis is an inflammatory disease of muscle, its cause unknown.
Polymyositis occurs throughout the world and, when associated with skin rash, is then referred to as "dermatomyositis." It can also affect other areas of the body and is, therefore, a systemic illness.
Polymyositis is generally initially treated with high doses of corticosteroids - medications related to cortisone - given by orally or intravenously.
  More results at FactBites »



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