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Encyclopedia > Pluripotent

In cell biology, a pluripotent cell is one able to differentiate into many cell types.


In the members of Kingdom Animalia, pluripotent stem cells which can develop into any of the three major tissue types: endoderm (interior gut lining), mesoderm (muscle, bone, blood), and ectoderm (epidermal tissues and nervous system). Pluripotent stem cells can eventually specialize in any bodily tissue, but they cannot themselves develop into a human being.


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Pluripotency Summary (545 words)
The cells of the inner cell mass are known as pluripotent.
Pluripotent stem cells have been isolated by one laboratory from the inner cell mass of human embryos in the blastocyst stage.
The endoderm is the innermost layer of the embryo.
We are interested in understanding the molecular mechanism that regulates pluripotency in embryonic stem cells (ESCs) (863 words)
The next group is pluripotent stem cells whose capacity is identical to that of totipotent stem cells except the lack of the function to form placenta*.
To dissect molecular pathways underlying pluripotency, we have conducted genome-wide gene expression analyses targeting human ESCs, and found that components of major signal transduction pathways including Wnt signaling are specifically enriched in the pluripotent state.
Nuclear transfer is an emerging technique to produce pluripotent embryonic stem cells from patient’s somatic cells while there are technical obstacles and ethical concerns due to the use of human oocytes.
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