Plasminogen activator inhibitor-2 (placental PAI) is a coagulation factor which inactivates tPA & urokinase. It is only present in relevant quantities during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosis during pregnancy. Hugo is a masculine name. ... The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... The Protein Data Bank (PDB) is a repository for 3-D structural data of proteins and nucleic acids. ... The Enzyme Commission number (EC number) is a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. ... In biology and evolutionary computation, a locus is the position of a gene (or other significant sequence) on a chromosome. ... Chromosome 18 is one of the 23 pairs of chromosomes in humans. ... The coagulation of blood is a complex process during which blood forms solid clots. ... TPA may refer to: Tampa International Airport (IATA code) Tissue plasminogen activator This is a disambiguation page — a navigational aid which lists other pages that might otherwise share the same title. ... Urokinase, also called urokinase-type Plasminogen Activator (uPA) is an enzyme (EC 3. ... Pregnant woman at 26-week gestation A pregnant woman near the end of her term Pregnancy is the carrying of one or more embryos or fetuses by female mammals, including humans, inside their bodies. ... The placenta is an ephemeral (temporary) organ present only in female placental mammals during gestation (pregnancy). ... Thrombosis is the formation of a clot or thrombus inside a blood vessel, obstructing the flow of blood through the circulatory system. ...
Plasminogen activator inhibitor-1 is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). ...
Category: Biochemistry stubs The coagulation of blood is a complex process during which blood forms solid clots. ... Fibrin is a protein involved in the clotting of blood. ... Thrombin (activated Factor II) is a coagulation protein that has many effects in the coagulation cascade. ... Factor V is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor. ... Factor VII (old name proconvertin) is one of the central proteins in the coagulation cascade. ... Factor VIII (FVIII) is an essential clotting factor. ... Factor IX (or Christmas factor or Christmas-Eve factor) is one of the serine proteases (EC 3. ... Factor X, also known by the eponym Stuart-Prower factor or as thrombokinase, is an enzyme ( EC 3. ... Factor XI or plasma thromboplastin antecent is one of the enzymes ( EC 3. ... The Hageman factor, is a plasma protein now usually known as factor XII. It is part of the coagulation cascade and activates factor XI and prekallikrein. ... Factor XIII or fibrin stabilizing factor is an enzyme (EC 2. ... High-molecular weight kininogen (HMWK), also known as the Williams-Fitzgerald-Flaujeac factor or the Fitzgerald factor is a protein from the blood coagulation system as well as the kinin-kallikrein system. ... Von Willebrand factor is a blood glycoprotein of the coagulation system. ... Thromboplastin is a substance present in tissues, platelets, and leukocytes necessary for the coagulation of blood; in the presence of calcium ions thromboplastin is necessary for the conversion of prothrombin to thrombin, an important step in coagulation of blood. ... Image:Antithrombin. ... Protein C is a major physiological anticoagulant. ... Protein S is a vitamin K-dependent plasma glycoprotein synthesized in the liver and it functions as a cofactor to Protein C in the inactivation of Factors Va and VIIIa. ... Protein Z is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. ... Protein Z-dependent protease inhibitor is a protein circulating in the blood which inhibits factors Xa and XIa of the coagulation cascade. ... Tissue Factor Pathway Inhibitor (or TFPI) is a protein that can reversibly inhibit Factor Xa (Xa), and after it has inhibted Xa, the Xa-TFPI complex can then inhibit the FVIIa-TF complex. ... Fibrinolysis is the process where a fibrin clot, the product of coagulation, is broken down. ... Plasmin is an important degrading enzyme (EC 3. ... In blood coagulation, tissue plasminogen activator (tPA) is an enzyme (EC 3. ... Urokinase, also called urokinase-type Plasminogen Activator (uPA) is an enzyme (EC 3. ... Plasminogen activator inhibitor-1 is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). ... Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin, an important enzyme that participates in fibrinolysis and degradation of various other proteins. ... TAFI (thrombin-activable fibrinolysis inhibitor) is a recently described plasma zymogen that, when exposed to the thrombin-thrombomodulin complex, is converted by proteolysis at Arg92 to a basic carboxypeptidase that inhibits fibrinolysis (TAFIa). ...
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