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Encyclopedia > Plasminogen

Plasmin is an important degrading enzyme (EC 3.4.21.7 (http://www.expasy.org/cgi-bin/nicezyme.pl?3.4.21.7)) of many proteins of blood plasma but specifically of fibrin clots. This process is termed fibrinolysis.


It is a serine protease that is released as plasminogen into the circulation and activated by tissue plasminogen activator (tPA), thrombin, fibrin and factor XII (Hageman factor). It is inactived by alpha 2-antiplasmin, a serine protease inhibitor (serpin).


Apart from fibrinolysis, plasmin proteolyses proteins in various other systems: it activates collagenases, some mediators of the complement system and weakens the wall of the Graafian follicle (leading to ovulation). It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor.


Deficiency in plasmin may lead to thrombosis, as clots are not degraded adequately.


External link

  • OMIM 173350 (http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=173350)

  Results from FactBites:
 
The Llinás group - Research - Human Plasminogen Kringle 1 (497 words)
The solution structure of the human plasminogen kringle 1 domain complexed to the antifibrinolytic drug 6-aminohexanoic acid (epsilon Ahx) was obtained on the basis of 1H-NMR spectroscopic data and dynamical simulated annealing calculations.
With the presence of disulfide bonds, plasminogen's structure is divided into a contiguous series of five homologous regions called kringles.
Plasminogen is converted to plasmin by cleavage of Lys-77 releasing the N-terminal peptide.
Oxford Biomedical Research (800) 692-4633 (164 words)
Plasminogen Description: Plasminogen, a single chain glycoprotein zymogen, is the precursor the fibrinolytic enzyme plasmin.
The native form of plasminogen is composed of 791 amino acids with glutamic acid located at the N-terminal portion (Glu-plasminogen).
Plasminogen is converted to plasmin via a cascade of various reactions that result in the hydrolysis of Arg560-Val561 peptide bond of plasminogen resulting in two chains that remain covalently associated by a disulfide bond.
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