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Encyclopedia > Plasmin

Plasmin is an important degrading enzyme (EC 3.4.21.7 (http://www.expasy.org/cgi-bin/nicezyme.pl?3.4.21.7)) of many proteins of blood plasma but specifically of fibrin clots. This process is termed fibrinolysis.


It is a serine protease that is released as plasminogen into the circulation and activated by tissue plasminogen activator (tPA), thrombin, fibrin and factor XII (Hageman factor). It is inactived by alpha 2-antiplasmin, a serine protease inhibitor (serpin).


Apart from fibrinolysis, plasmin proteolyses proteins in various other systems: it activates collagenases, some mediators of the complement system and weakens the wall of the Graafian follicle (leading to ovulation). It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor.


Deficiency in plasmin may lead to thrombosis, as clots are not degraded adequately.


External link

  • OMIM 173350 (http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=173350)

  Results from FactBites:
 
Plasmin - Wikipedia, the free encyclopedia (140 words)
Plasmin is an important degrading enzyme (EC 3.4.21.7) of many proteins of blood plasma but specifically of fibrin clots.
Apart from fibrinolysis, plasmin proteolyses proteins in various other systems: it activates collagenases, some mediators of the complement system and weakens the wall of the Graafian follicle (leading to ovulation).
Deficiency in plasmin may lead to thrombosis, as clots are not degraded adequately.
Potential Mechanisms for the Plasmin-Mediated Release and Activation of Latent Transforming Growth Factor-{beta}1 from ... (6020 words)
by 0.01 U/ml plasmin from RC matrices by 57–85% at all
of low-dose plasmin is LTBP1, causing the release of latent
Plasmin is also shown to cleave small quantities of the large complex in the plasmin-sensitive hinge region, releasing large latent TGF-ß1 complexes (2), and small amounts of active TGF-ß1 from the soluble large complex (3).
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