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Encyclopedia > Phillip Allen Sharp

Phillip Allen Sharp (born 1944), U.S. geneticist and molecular biologist; co-discovered gene splicing; shared the 1993 Nobel Prize in Physiology or Medicine with Richard J. Roberts for "the discovery that genes in eukaryotes are not contiguous strings but contain introns, and that the splicing of messenger RNA to delete those introns can occur in different ways, yielding different proteins from the same DNA sequence". 1944 was a leap year starting on Saturday (link will take you to calendar). ... The United States of America — also referred to as the United States, the U.S.A., the U.S., America, the States, or (archaically) Columbia—is a federal republic of 50 states located primarily in central North America (with the exception of two states: Alaska and Hawaii). ... Genetics (from the Greek genno γεννώ= give birth) is the science of genes, heredity, and the variation of organisms. ... Molecular biology is the study of biology at a molecular level. ... List of Nobel Prize laureates in Physiology or Medicine from 1901 to the present day. ... Richard J. Roberts (b. ... This stylistic schematic diagram shows a gene in relation to the double helix structure of DNA and to a chromosome (right). ... Kingdoms Animalia - Animals Fungi Plantae - Plants Protista A eukaryote (also spelled eucaryote) is an organism with complex cells, in which the genetic material is organized into membrane-bound nuclei. ... Diagram of the location of introns and exons within a gene. ... The life cycle of an mRNA in a eukaryotic cell. ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ...

Sharp was born in Falmouth, Kentucky. After his Ph.D. in chemistry at the University of Illinois in 1969, he worked at the California Institute of Technology until 1971, where he studied plasmids and, later, gene expression in human cells at the Cold Spring Harbor Laboratory under James Dewey Watson. Falmouth is a city located in Pendleton County, Kentucky. ... The University of Illinois is the set of three public universities in Illinois. ... The California Institute of Technology (commonly known as Caltech) is a private, coeducational university located in Pasadena, California, in the United States. ... Figure 1 : Schematic drawing of a bacterium with plasmids enclosed. ... Gene expression (also protein expression or often simply expression) is the process by which a genes information is converted into the structures and functions of a cell. ... The Cold Spring Harbor Laboratory is a research and educational institution, consisting of science laboratories located in Cold Spring Harbor, New York on Long Island, USA. The Laboratory has research programs focusing on cancer, neurobiology, plant genetics, genomics and bioinformatics, and has a broad educational mission, including the recently established... James Watson James Dewey Watson (born April 6, 1928) is one of the discoverers of the structure of the DNA molecule. ...

In 1974, he was offered a position at MIT by biologist Salvador Luria. He is currently a professor of biology at MIT. The Massachusetts Institute of Technology, or MIT, is a research and educational institution located in the city of Cambridge, Massachusetts, USA. MIT is a world leader in science and technology, as well as in many other fields, including management, economics, linguistics, political science, and philosophy. ... Salvador Edward Luria (August 13, 1912 - February 6, 1991) was a naturalized American microbiologist whose pioneering work on phage helped open up molecular biology. ...

Sharp married Ann Holcombe in 1964. They have three daughters.

External links

  Results from FactBites:
Sharp - Wikipedia, the free encyclopedia (242 words)
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Sharp, Phillip Allen (born 1944), U.S. geneticist and molecular biologist
Robert Phillip Sharp (2065 words)
Sharp played quarterback for the Caltech football team for three years, thrilled to be able to compete against teams like UCLA at the Coliseum (Caltech didn’t win, but gave UCLA a good run for their money) and to have the Rose Bowl as home field.
Sharp loved taking people on field trips, feeling that “you have to bring them into the fold by taking them out to have a look at nature.” He felt sorry for the division’s secretaries and lab technicians because they were always left behind when the faculty and students went off.
Sharp is survived by two children, Kristin Lytle and Bruce Sharp, two grandchildren, Lenore and Mathew Lytle, and many generations of fond students and colleagues.
  More results at FactBites »



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