Pergonal® is a infertility medicine used to stimulate ovarianfollicles in infertility treatments, i.e. IVF. It is a preparation of gonadotropins containing follicle stimulating hormone and luteinizing hormone and extracted from the urine of postmenopausal women. It became available in the 1960s through the Serono company. It has been told that initially the company went to Italian convents and asked elderly nuns to establish collection centers. By 2000 it has been largely replaced by purer forms of urinary gonadotropins and recombinant FSH preparations. In botany, a follicle is a type of simple dry fruit produced by certain flowering plants. ... Infertility is the inability to naturally conceive a child or the inability to carry a pregnancy to term. ... In vitro fertilization (IVF) is a technique in which egg cells are fertilized outside the mothers body in cases where conception is difficult or impossible through normal intercourse. ... Gonadotropins are protein hormones secreted by gonadotrope cells of the pituitary gland of vertebrates. ... Follicle stimulating hormone (FSH) is a hormone produced by gonadotropes in the anterior pituitary gland. ... Luteinizing hormone (LH) is a hormone synthesised and secreted by gonadotropes in the anterior lobe of the pituitary gland. ... Menopause (also known as the Change of life or climacteric) is a stage of the human female reproductive cycle that occurs as the ovaries stop producing estrogen, causing the reproductive system to gradually shut down. ... The 1960s decade refers to the years from 1960 to 1969, inclusive. ... Serono S.A., formerly Ares-Serono AG, is a biotechnology company headquartered in Geneva, Switzerland. ... This article is about an abbey as a religious building. ... Nun in cloister, 1930; photograph by Doris Ulmann In general, a nun is a female ascetic who chooses to voluntarily leave mainstream society and live her life in prayer and contemplation in a monastery or convent. ... This article is about the year 2000. ... Recombinant proteins are proteins that are produced by different genetically modified organisms following insertion of the relevant DNA into their genome. ...
Its main side effects are multiple births and the ovarian hyperstimulation syndrome. Identical Triplet Sisters Fraternal twin boys in the tub Twins, triplets and other multiple births occur with to varying degrees in most animal species, although the term is most applicable to species in the Placentalia subclass. ... Ovarian hyperstimulation syndrome (OHSS) is a complication from some forms of fertility medication. ...
Pergonal and hCG are given in a sequential manner for the induction of ovulation and pregnancy in the anovulatory infertile patient when the cause of anovulation is functional and not due to primary ovarian failure (inability of the ovaries to respond to any hormonal stimulation, often due to a postmenopausal condition).
Pergonal and hCG may also be used to stimulate the development of multiple follicles in ovulatory patients participating in an IVF program.
Pergonal with concomitant hCG is indicated for the stimulation of spermatogenesis (sperm development) in men who have primary or secondary hypogonadotropic hypogonadism (inadequate testicular function).
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